6tdn - Revision history

OCA at 11:03, 14 June 2023

OCA — Wed, 14 Jun 2023 11:03:14 GMT

←Older revision		Revision as of 11:03, 14 June 2023
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	==Bam_5925cDD 5924nDD docking domains==		==Bam_5925cDD 5924nDD docking domains==
-	<StructureSection load='6tdn' size='340' side='right'caption='[[6tdn~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>	+	<StructureSection load='6tdn' size='340' side='right'caption='[[6tdn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tdn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Burcm Burcm~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TDN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tdn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_ambifaria_AMMD Burkholderia ambifaria AMMD]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TDN FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bamb_5924 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339670 BURCM])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdn OCA], [https://pdbe.org/6tdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tdn RCSB], [https://www.ebi.ac.uk/pdbsum/6tdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdn OCA], [~~http~~://pdbe.org/6tdn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tdn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tdn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdn ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q0B303_BURCM Q0B303_BURCM] [https://www.uniprot.org/uniprot/Q0B304_BURCM Q0B304_BURCM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burcm~~]]	+	[[Category: Burkholderia ambifaria AMMD]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chagot, B]]	+	[[Category: Chagot B]]
-	[[Category: Risser, F]]	+	[[Category: Risser F]]
-	~~[[Category: Docking domain]]~~	+
-	~~[[Category: Polyketide synthase]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 06:37, 7 October 2020

OCA — Wed, 07 Oct 2020 06:37:22 GMT

←Older revision		Revision as of 06:37, 7 October 2020
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	==Bam_5925cDD 5924nDD docking domains==		==Bam_5925cDD 5924nDD docking domains==
-	<StructureSection load='6tdn' size='340' side='right'caption='[[6tdn]]' scene=''>	+	<StructureSection load='6tdn' size='340' side='right'caption='[[6tdn]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TDN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tdn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burcm Burcm]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TDN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdn OCA], [http://pdbe.org/6tdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tdn RCSB], [http://www.ebi.ac.uk/pdbsum/6tdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdn ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bamb_5924 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339670 BURCM])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdn OCA], [http://pdbe.org/6tdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tdn RCSB], [http://www.ebi.ac.uk/pdbsum/6tdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Modular polyketide synthases (PKSs) are molecular-scale assembly lines comprising multiple gigantic polypeptide subunits. Faithful ordering of the subunits is mediated by extreme C- and N-terminal regions called docking domains (DDs). Decrypting how specificity is achieved by these elements is important both for understanding PKS function and modifying it to generate useful polyketide analogues for biological evaluation. Here we report the biophysical and structural characterisation of all six PKS/PKS interfaces in the unusual, chimaeric cis-AT/trans-AT PKS pathway responsible for biosynthesis of the antibiotic enacyloxin IIa in Burkholderia ambifaria. Taken together with previous work, our data reveal that specificity is achieved in the enacyloxin PKS by deploying at least three functionally orthogonal classes of DDs. We also demonstrate for the first time that cis-AT PKS subunits incorporate DDs with intrinsically disordered character, reinforcing the utility of such regions for achieving both medium affinity and high specificity at PKS intersubunit junctions. Overall, this work substantially increases the number of orthogonal DDs available for creating novel, highly-specific interfaces within cis- and trans-AT PKSs and their hybrids. It also reveals unexpected sequence/structure relationships in PKS DDs, identifying major current limitations to both accurately predicting and categorising these useful protein-protein interaction motifs.
		+
		+	Towards improved understanding of intersubunit interactions in modular polyketide biosynthesis: docking in the enacyloxin IIa polyketide synthase.,Risser F, Collin S, Dos Santos-Morais R, Gruez A, Chagot B, Weissman KJ J Struct Biol. 2020 Jul 24:107581. doi: 10.1016/j.jsb.2020.107581. PMID:32717326<ref>PMID:32717326</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tdn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Burcm]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chagot B]]	+	[[Category: Chagot, B]]
-	[[Category: Risser F]]	+	[[Category: Risser, F]]
		+	[[Category: Docking domain]]
		+	[[Category: Polyketide synthase]]
		+	[[Category: Protein binding]]

OCA at 09:46, 12 August 2020

OCA — Wed, 12 Aug 2020 09:46:18 GMT

←Older revision		Revision as of 09:46, 12 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6tdn ~~is ON HOLD until Paper Publication~~	+	==Bam_5925cDD 5924nDD docking domains==
-		+	<StructureSection load='6tdn' size='340' side='right'caption='[[6tdn]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TDN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdn OCA], [http://pdbe.org/6tdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tdn RCSB], [http://www.ebi.ac.uk/pdbsum/6tdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chagot B]]
		+	[[Category: Risser F]]

OCA at 06:12, 22 July 2020

OCA — Wed, 22 Jul 2020 06:12:27 GMT

←Older revision		Revision as of 06:12, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tdn is ON HOLD	+	The entry 6tdn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6tdn" [edit=sysop:move=sysop]

OCA — Wed, 20 Nov 2019 13:37:46 GMT

Protected "6tdn" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:37, 20 November 2019

OCA: New page: '''Unreleased structure''' The entry 6tdn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Nov 2019 13:37:44 GMT

New page: '''Unreleased structure''' The entry 6tdn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tdn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]