6tkk - Revision history

OCA at 13:04, 24 January 2024

OCA — Wed, 24 Jan 2024 13:04:11 GMT

←Older revision		Revision as of 13:04, 24 January 2024
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-	====	+	==Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide==
-	<StructureSection load='6tkk' size='340' side='right'caption='[[6tkk]]' scene=''>	+	<StructureSection load='6tkk' size='340' side='right'caption='[[6tkk]], [[Resolution\|resolution]] 1.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TKK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tkk OCA], [~~http~~://pdbe.org/6tkk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tkk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tkk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tkk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.06Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tkk OCA], [https://pdbe.org/6tkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tkk RCSB], [https://www.ebi.ac.uk/pdbsum/6tkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tkk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NRP1_HUMAN NRP1_HUMAN] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
		+
		+	==See Also==
		+	*[[Neuropilin\|Neuropilin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Djordjevic S]]
		+	[[Category: Eldrid C]]
		+	[[Category: Fotinou C]]
		+	[[Category: Yelland T]]
		+	[[Category: Yu L]]

OCA at 12:30, 16 December 2020

OCA — Wed, 16 Dec 2020 12:30:20 GMT

←Older revision		Revision as of 12:30, 16 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6tkk ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6tkk' size='340' side='right'caption='[[6tkk]]' scene=''>
-	~~Authors~~: ~~Eldrid, C~~.~~, Yu, L~~.~~, Yelland, T~~.~~, Fotinou, C., Djordjevic, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Neuropilin 1-b1 domain in~~ a ~~complex with~~ the ~~C-terminal VEGFB186 peptide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tkk OCA], [http://pdbe.org/6tkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tkk RCSB], [http://www.ebi.ac.uk/pdbsum/6tkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tkk ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures]~~]	+	</table>
-	[~~[Category~~: ~~Fotinou, C~~]]	+	__TOC__
-	[[~~Category~~: ~~Djordjevic~~, S]]	+	</StructureSection>
-	[~~[Category~~: ~~Yelland~~, T]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yu, L~~]]	+	[[Category: Z-disk]]
-	[[Category: ~~Eldrid, C~~]]	+

OCA at 06:17, 22 July 2020

OCA — Wed, 22 Jul 2020 06:17:30 GMT

←Older revision		Revision as of 06:17, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tkk is ON HOLD	+	The entry 6tkk is ON HOLD until Paper Publication

	Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S.		Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S.
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	Description: Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide		Description: Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Yu, L]]
	[[Category: Fotinou, C]]		[[Category: Fotinou, C]]
-	[[Category: Eldrid, C]]
	[[Category: Djordjevic, S]]		[[Category: Djordjevic, S]]
	[[Category: Yelland, T]]		[[Category: Yelland, T]]
		+	[[Category: Yu, L]]
		+	[[Category: Eldrid, C]]

OCA: Protected "6tkk" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2019 06:30:14 GMT

Protected "6tkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 4 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tkk is ON HOLD Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S. Description: Neuropilin 1-b1 domain in a complex with the C-t...

OCA — Wed, 04 Dec 2019 06:30:13 GMT

New page: '''Unreleased structure''' The entry 6tkk is ON HOLD Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S. Description: Neuropilin 1-b1 domain in a complex with the C-t...

New page

'''Unreleased structure'''

The entry 6tkk is ON HOLD

Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S.

Description: Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
[[Category: Unreleased Structures]]
[[Category: Yu, L]]
[[Category: Fotinou, C]]
[[Category: Eldrid, C]]
[[Category: Djordjevic, S]]
[[Category: Yelland, T]]