OCA at 13:04, 24 January 2024

OCA — Wed, 24 Jan 2024 13:04:35 GMT

←Older revision		Revision as of 13:04, 24 January 2024
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	==CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 (P212121)==		==CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 (P212121)==
-	<StructureSection load='6tl7' size='340' side='right'caption='[[6tl7]]' scene=''>	+	<StructureSection load='6tl7' size='340' side='right'caption='[[6tl7]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tl7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TL7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl7 OCA], [~~http~~://pdbe.org/6tl7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tl7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tl7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.11Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl7 OCA], [https://pdbe.org/6tl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tl7 RCSB], [https://www.ebi.ac.uk/pdbsum/6tl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN] Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.<ref>PMID:12384789</ref> <ref>PMID:12807963</ref> <ref>PMID:15060104</ref> <ref>PMID:15276231</ref> <ref>PMID:15860461</ref> Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.<ref>PMID:12384789</ref> <ref>PMID:12807963</ref> <ref>PMID:15060104</ref> <ref>PMID:15276231</ref> <ref>PMID:15860461</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN] Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.<ref>PMID:9052782</ref> <ref>PMID:11821063</ref> <ref>PMID:12354387</ref>
		+
		+	==See Also==
		+	*[[LDL receptor\|LDL receptor]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fiegen D]]		[[Category: Fiegen D]]
	[[Category: Nar H]]		[[Category: Nar H]]
	[[Category: Schnapp G]]		[[Category: Schnapp G]]

OCA at 10:50, 22 July 2020

OCA — Wed, 22 Jul 2020 10:50:19 GMT

←Older revision		Revision as of 10:50, 22 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6tl7 is ~~ON HOLD~~	+	==CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 (P212121)==
-		+	<StructureSection load='6tl7' size='340' side='right'caption='[[6tl7]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TL7 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl7 OCA], [http://pdbe.org/6tl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tl7 RCSB], [http://www.ebi.ac.uk/pdbsum/6tl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl7 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fiegen D]]
		+	[[Category: Nar H]]
		+	[[Category: Schnapp G]]

OCA: Protected "6tl7" [edit=sysop:move=sysop]

OCA — Wed, 11 Dec 2019 13:36:02 GMT

Protected "6tl7" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:36, 11 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tl7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Dec 2019 13:36:00 GMT

New page: '''Unreleased structure''' The entry 6tl7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tl7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6tl7 - Revision history

OCA at 13:04, 24 January 2024

OCA at 10:50, 22 July 2020

OCA: Protected "6tl7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6tl7 is ON HOLD Authors: Description: Category: Unreleased Structures