6tl8 - Revision history

OCA at 13:04, 24 January 2024

OCA — Wed, 24 Jan 2024 13:04:36 GMT

←Older revision		Revision as of 13:04, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6tl8' size='340' side='right'caption='[[6tl8]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6tl8' size='340' side='right'caption='[[6tl8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tl8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TL8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Lrfn4, Salm3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl8 OCA], [~~http~~://pdbe.org/6tl8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tl8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tl8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl8 OCA], [https://pdbe.org/6tl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tl8 RCSB], [https://www.ebi.ac.uk/pdbsum/6tl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN]] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref>	+	[https://www.uniprot.org/uniprot/LRFN4_MOUSE LRFN4_MOUSE] Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery.<ref>PMID:16828986</ref> <ref>PMID:18585462</ref> [https://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bae, S]]	+	[[Category: Mus musculus]]
-	[[Category: Kajander, T]]	+	[[Category: Bae S]]
-	[[Category: Karki, S]]	+	[[Category: Kajander T]]
-	[[Category: Ko, J]]	+	[[Category: Karki S]]
-	[[Category: Shkumatov~~, A V]]~~	+	[[Category: Ko J]]
-	~~[[Category: Cell adhesion]]~~	+	[[Category: Shkumatov AV]]
-	~~[[Category: Leucine rich repeat]]~~	+
-	~~[[Category: Salm3]]~~	+
-	~~[[Category: Synapse~~]]	+

OCA at 11:34, 29 July 2020

OCA — Wed, 29 Jul 2020 11:34:56 GMT

←Older revision		Revision as of 11:34, 29 July 2020
Line 1:		Line 1:

	==Structural basis of SALM3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases==		==Structural basis of SALM3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases==
-	<StructureSection load='6tl8' size='340' side='right'caption='[[6tl8]]' scene=''>	+	<StructureSection load='6tl8' size='340' side='right'caption='[[6tl8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tl8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TL8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl8 OCA], [http://pdbe.org/6tl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tl8 RCSB], [http://www.ebi.ac.uk/pdbsum/6tl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl8 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lrfn4, Salm3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl8 OCA], [http://pdbe.org/6tl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tl8 RCSB], [http://www.ebi.ac.uk/pdbsum/6tl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN]] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Synaptic adhesion molecules play an important role in the formation, maintenance and refinement of neuronal connectivity. Recently, several leucine rich repeat (LRR) domain containing neuronal adhesion molecules have been characterized including netrin G-ligands, SLITRKs and the synaptic adhesion-like molecules (SALMs). Dysregulation of these adhesion molecules have been genetically and functionally linked to various neurological disorders. Here we investigated the molecular structure and mechanism of ligand interactions for the postsynaptic SALM3 adhesion protein with its presynaptic ligand, receptor protein tyrosine phosphatase sigma (PTPsigma). We solved the crystal structure of the dimerized LRR domain of SALM3, revealing the conserved structural features and mechanism of dimerization. Furthermore, we determined the complex structure of SALM3 with PTPsigma using small angle X-ray scattering, revealing a 2:2 complex similar to that observed for SALM5. Solution studies unraveled additional flexibility for the complex structure, but validated the uniform mode of action for SALM3 and SALM5 to promote synapse formation. The relevance of the key interface residues was further confirmed by mutational analysis with cellular binding assays and artificial synapse formation assays. Collectively, our results suggest that SALM3 dimerization is a pre-requisite for the SALM3-PTPsigma complex to exert synaptogenic activity.
		+
		+	Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPsigma.,Karki S, Shkumatov AV, Bae S, Kim H, Ko J, Kajander T Sci Rep. 2020 Jul 14;10(1):11557. doi: 10.1038/s41598-020-68502-4. PMID:32665594<ref>PMID:32665594</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tl8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bae S]]	+	[[Category: Bae, S]]
-	[[Category: Kajander T]]	+	[[Category: Kajander, T]]
-	[[Category: Karki S]]	+	[[Category: Karki, S]]
-	[[Category: Ko J]]	+	[[Category: Ko, J]]
-	[[Category: Shkumatov AV]]	+	[[Category: Shkumatov, A V]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Leucine rich repeat]]
		+	[[Category: Salm3]]
		+	[[Category: Synapse]]

OCA at 10:50, 22 July 2020

OCA — Wed, 22 Jul 2020 10:50:23 GMT

←Older revision		Revision as of 10:50, 22 July 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tl8 is ~~ON HOLD until Paper Publication~~	+	==Structural basis of SALM3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases==
-		+	<StructureSection load='6tl8' size='340' side='right'caption='[[6tl8]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TL8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TL8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tl8 OCA], [http://pdbe.org/6tl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tl8 RCSB], [http://www.ebi.ac.uk/pdbsum/6tl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tl8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bae S]]
		+	[[Category: Kajander T]]
		+	[[Category: Karki S]]
		+	[[Category: Ko J]]
		+	[[Category: Shkumatov AV]]

OCA: Protected "6tl8" [edit=sysop:move=sysop]

OCA — Wed, 11 Dec 2019 13:36:06 GMT

Protected "6tl8" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:36, 11 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tl8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Dec 2019 13:36:04 GMT

New page: '''Unreleased structure''' The entry 6tl8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tl8 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]