6tni - Revision history

OCA at 10:18, 22 May 2024

OCA — Wed, 22 May 2024 10:18:41 GMT

←Older revision		Revision as of 10:18, 22 May 2024
Line 3:		Line 3:
	<SX load='6tni' size='340' side='right' viewer='molstar' caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6tni' size='340' side='right' viewer='molstar' caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TNI FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FANCD2 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9031 CHICK])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [~~http~~://pdbe.org/6tni PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tni PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [https://pdbe.org/6tni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [https://www.ebi.ac.uk/pdbsum/6tni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F1NP22_CHICK F1NP22_CHICK]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alcon, P]]	+	[[Category: Alcon P]]
-	[[Category: Passmore~~, L A~~]]	+	[[Category: Passmore LA]]
-	[[Category: Shakeel, S]]	+	[[Category: Shakeel S]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna damage]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Fanconi anaemia]]~~	+
-	~~[[Category: Inter-strand crosslink]]~~	+
-	~~[[Category: Ubiquitin~~]]	+

OCA at 06:32, 11 April 2020

OCA — Sat, 11 Apr 2020 06:32:14 GMT

←Older revision		Revision as of 06:32, 11 April 2020
Line 3:		Line 3:
	<SX load='6tni' size='340' side='right' viewer='molstar' caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6tni' size='340' side='right' viewer='molstar' caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TNI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FANCD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FANCD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [http://pdbe.org/6tni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [http://www.ebi.ac.uk/pdbsum/6tni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [http://pdbe.org/6tni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [http://www.ebi.ac.uk/pdbsum/6tni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:01, 7 March 2020

OCA — Sat, 07 Mar 2020 01:01:29 GMT

←Older revision		Revision as of 01:01, 7 March 2020
Line 1:		Line 1:

	==Structure of FANCD2 homodimer==		==Structure of FANCD2 homodimer==
-	<~~StructureSection~~ load='6tni' size='340' side='right'caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<SX load='6tni' size='340' side='right' viewer='molstar' caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TNI FirstGlance]. <br>		<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TNI FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chick]]		[[Category: Chick]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 10:32, 26 February 2020

OCA — Wed, 26 Feb 2020 10:32:13 GMT

←Older revision		Revision as of 10:32, 26 February 2020
Line 3:		Line 3:
	<StructureSection load='6tni' size='340' side='right'caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='6tni' size='340' side='right'caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TNI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [http://pdbe.org/6tni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [http://www.ebi.ac.uk/pdbsum/6tni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FANCD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [http://pdbe.org/6tni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [http://www.ebi.ac.uk/pdbsum/6tni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair is monoubiquitination of the FANCD2-FANCI heterodimer, which then recruits nucleases to remove the DNA lesion. Here, we use cryo-EM to determine the structures of recombinant chicken FANCD2 and FANCI complexes. FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). Ubiquitin is positioned at the interface of FANCD2 and FANCI, where it acts as a covalent molecular pin to trap the complex on DNA. In contrast, isolated FANCD2 is a homodimer that is unable to bind DNA, suggestive of an autoinhibitory mechanism that prevents premature activation. Together, our work suggests that FANCD2-FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
		+
		+	FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.,Alcon P, Shakeel S, Chen ZA, Rappsilber J, Patel KJ, Passmore LA Nat Struct Mol Biol. 2020 Feb 17. pii: 10.1038/s41594-020-0380-1. doi:, 10.1038/s41594-020-0380-1. PMID:32066963<ref>PMID:32066963</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tni" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Alcon, P]]		[[Category: Alcon, P]]

OCA at 06:38, 19 February 2020

OCA — Wed, 19 Feb 2020 06:38:49 GMT

←Older revision		Revision as of 06:38, 19 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tni is ~~ON HOLD until Dec 08 2021~~	+	==Structure of FANCD2 homodimer==
-		+	<StructureSection load='6tni' size='340' side='right'caption='[[6tni]], [[Resolution\|resolution]] 3.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6tni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TNI FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tni OCA], [http://pdbe.org/6tni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tni RCSB], [http://www.ebi.ac.uk/pdbsum/6tni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tni ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Alcon, P]]
		+	[[Category: Passmore, L A]]
		+	[[Category: Shakeel, S]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna damage]]
		+	[[Category: Dna repair]]
		+	[[Category: Fanconi anaemia]]
		+	[[Category: Inter-strand crosslink]]
		+	[[Category: Ubiquitin]]

OCA at 02:37, 13 February 2020

OCA — Thu, 13 Feb 2020 02:37:39 GMT

←Older revision		Revision as of 02:37, 13 February 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tni is ON HOLD	+	The entry 6tni is ON HOLD until Dec 08 2021

	Authors:		Authors:

OCA: Protected "6tni" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2019 05:52:13 GMT

Protected "6tni" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 18 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tni is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Dec 2019 05:52:11 GMT

New page: '''Unreleased structure''' The entry 6tni is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tni is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]