6tnp - Revision history

OCA at 13:05, 24 January 2024

OCA — Wed, 24 Jan 2024 13:05:39 GMT

←Older revision		Revision as of 13:05, 24 January 2024
Line 1:		Line 1:

-	====	+	==Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide==
-	<StructureSection load='6tnp' size='340' side='right'caption='[[6tnp]]' scene=''>	+	<StructureSection load='6tnp' size='340' side='right'caption='[[6tnp]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tnp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TNP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnp OCA], [~~http~~://pdbe.org/6tnp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tnp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tnp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO8:(2~{S})-~{N}-[2-[[(2~{S})-1-[[(2~{S},3~{R})-3-[(2~{S},3~{R},4~{R},5~{R},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-1-[[(2~{S})-1-[(2~{S})-2-aminocarbonylpyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]-1-[(2~{S})-2-azanylpropanoyl]pyrrolidine-2-carboxamide'>NO8</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnp OCA], [https://pdbe.org/6tnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tnp RCSB], [https://www.ebi.ac.uk/pdbsum/6tnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnp ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.
		+
		+	Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.,Macias-Leon J, Bermejo IA, Asin A, Garcia-Garcia A, Companon I, Jimenez-Moreno E, Coelho H, Mangini V, Albuquerque IS, Marcelo F, Asensio JL, Bernardes GJL, Joshi HJ, Fiammengo R, Blixt O, Hurtado-Guerrero R, Corzana F Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. doi: 10.1039/d0cc06349e. PMID:33211039<ref>PMID:33211039</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tnp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Corzana F]]
		+	[[Category: Hurtado-Guerrero R]]
		+	[[Category: Macias-Leon J]]

OCA at 09:36, 18 November 2020

OCA — Wed, 18 Nov 2020 09:36:06 GMT

←Older revision		Revision as of 09:36, 18 November 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tnp ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6tnp' size='340' side='right'caption='[[6tnp]]' scene=''>
-	~~Authors~~: ~~Macias-Leon, J~~.~~, Corzana, F~~.~~, Hurtado~~-~~Guerrero, R~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Crystal structure of~~ a ~~ScFv antibody in complex with a Tn glycopeptide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnp OCA], [http://pdbe.org/6tnp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tnp RCSB], [http://www.ebi.ac.uk/pdbsum/6tnp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnp ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures]~~]	+	</table>
-	[[~~Category~~: ~~Macias~~-~~Leon~~, J]]	+	__TOC__
-	[[Category: ~~Corzana, F~~]]	+	</StructureSection>
-	[[Category: ~~Hurtado~~-~~Guerrero, R~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "6tnp" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2019 05:52:36 GMT

Protected "6tnp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 18 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tnp is ON HOLD until Paper Publication Authors: Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. Description: Crystal structure of a ScFv antibo...

OCA — Wed, 18 Dec 2019 05:52:34 GMT

New page: '''Unreleased structure''' The entry 6tnp is ON HOLD until Paper Publication Authors: Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. Description: Crystal structure of a ScFv antibo...

New page

'''Unreleased structure'''

The entry 6tnp is ON HOLD until Paper Publication

Authors: Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R.

Description: Crystal structure of a ScFv antibody in complex with a Tn glycopeptide
[[Category: Unreleased Structures]]
[[Category: Macias-Leon, J]]
[[Category: Corzana, F]]
[[Category: Hurtado-Guerrero, R]]