OCA at 13:06, 24 January 2024

OCA — Wed, 24 Jan 2024 13:06:14 GMT

←Older revision		Revision as of 13:06, 24 January 2024
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-	====	+	==Crystal structure of a PP2A B56y/HTLV-1 integrase complex==
-	<StructureSection load='6toq' size='340' side='right'caption='[[6toq]]' scene=''>	+	<StructureSection load='6toq' size='340' side='right'caption='[[6toq]], [[Resolution\|resolution]] 3.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6toq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TOQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6toq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6toq OCA], [~~http~~://pdbe.org/6toq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6toq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6toq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6toq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.164Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6toq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6toq OCA], [https://pdbe.org/6toq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6toq RCSB], [https://www.ebi.ac.uk/pdbsum/6toq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6toq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1Y1CAL3_9DELA A0A1Y1CAL3_9DELA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus and the most oncogenic pathogen. Many of the ~20 million HTLV-1 infected people will develop severe leukaemia or an ALS-like motor disease, unless a therapy becomes available. A key step in the establishment of infection is the integration of viral genetic material into the host genome, catalysed by the retroviral integrase (IN) enzyme. Here, we use X-ray crystallography and single-particle cryo-electron microscopy to determine the structure of the functional deltaretroviral IN assembled on viral DNA ends and bound to the B56gamma subunit of its human host factor, protein phosphatase 2 A. The structure reveals a tetrameric IN assembly bound to two molecules of the phosphatase via a conserved short linear motif. Insight into the deltaretroviral intasome and its interaction with the host will be crucial for understanding the pattern of integration events in infected individuals and therefore bears important clinical implications.
		+
		+	Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.,Barski MS, Minnell JJ, Hodakova Z, Pye VE, Nans A, Cherepanov P, Maertens GN Nat Commun. 2020 Oct 7;11(1):5043. doi: 10.1038/s41467-020-18874-y. PMID:33028863<ref>PMID:33028863</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6toq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Human T-cell leukemia virus type I]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Barski MS]]
		+	[[Category: Maertens GN]]
		+	[[Category: Minnell JJ]]

OCA at 08:13, 21 October 2020

OCA — Wed, 21 Oct 2020 08:13:40 GMT

←Older revision		Revision as of 08:13, 21 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6toq ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6toq' size='340' side='right'caption='[[6toq]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6toq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6toq OCA], [http://pdbe.org/6toq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6toq RCSB], [http://www.ebi.ac.uk/pdbsum/6toq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6toq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:19, 22 July 2020

OCA — Wed, 22 Jul 2020 06:19:44 GMT

←Older revision		Revision as of 06:19, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6toq is ON HOLD	+	The entry 6toq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6toq" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2019 05:56:25 GMT

Protected "6toq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:56, 18 December 2019

OCA: New page: '''Unreleased structure''' The entry 6toq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Dec 2019 05:56:23 GMT

New page: '''Unreleased structure''' The entry 6toq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6toq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6toq - Revision history

OCA at 13:06, 24 January 2024

OCA at 08:13, 21 October 2020

OCA at 06:19, 22 July 2020

OCA: Protected "6toq" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6toq is ON HOLD Authors: Description: Category: Unreleased Structures