6tpk - Revision history

OCA at 07:04, 2 September 2020

OCA — Wed, 02 Sep 2020 07:04:21 GMT

←Older revision		Revision as of 07:04, 2 September 2020
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/OXYR_HUMAN OXYR_HUMAN]] Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.		[[http://www.uniprot.org/uniprot/OXYR_HUMAN OXYR_HUMAN]] Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin receptor (OTR) across several species. Here, we report the crystal structure of human OTR in complex with retosiban, a nonpeptidic antagonist developed as an oral drug for the prevention of preterm labor. Our structure reveals insights into the detailed interactions between the G protein-coupled receptor (GPCR) and an OTR-selective antagonist. The observation of an extrahelical cholesterol molecule, binding in an unexpected location between helices IV and V, provides a structural rationale for its allosteric effect and critical influence on OTR function. Furthermore, our structure in combination with experimental data allows the identification of a conserved neurohypophyseal receptor-specific coordination site for Mg(2+) that acts as potent, positive allosteric modulator for agonist binding. Together, these results further our molecular understanding of the oxytocin/vasopressin receptor family and will facilitate structure-guided development of new therapeutics.
		+
		+	Crystal structure of the human oxytocin receptor.,Waltenspuhl Y, Schoppe J, Ehrenmann J, Kummer L, Pluckthun A Sci Adv. 2020 Jul 15;6(29):eabb5419. doi: 10.1126/sciadv.abb5419. eCollection, 2020 Jul. PMID:32832646<ref>PMID:32832646</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tpk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:34, 19 August 2020

OCA — Wed, 19 Aug 2020 06:34:39 GMT

←Older revision		Revision as of 06:34, 19 August 2020
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-	==~~Structure~~ of ~~a Eukaryotic Protein~~==	+	==Crystal structure of the human oxytocin receptor==
-	<StructureSection load='6tpk' size='340' side='right'caption='[[6tpk]]' scene=''>	+	<StructureSection load='6tpk' size='340' side='right'caption='[[6tpk]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TPK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tpk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TPK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpk OCA], [http://pdbe.org/6tpk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tpk RCSB], [http://www.ebi.ac.uk/pdbsum/6tpk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpk ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NU2:(3~{R},6~{R})-6-[(2~{S})-butan-2-yl]-3-(2,3-dihydro-1~{H}-inden-2-yl)-1-[(1~{R})-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxidanylidene-ethyl]piperazine-2,5-dione'>NU2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OXTR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpk OCA], [http://pdbe.org/6tpk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tpk RCSB], [http://www.ebi.ac.uk/pdbsum/6tpk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OXYR_HUMAN OXYR_HUMAN]] Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ehrenmann J]]	+	[[Category: Ehrenmann, J]]
-	[[Category: Kummer L]]	+	[[Category: Kummer, L]]
-	[[Category: Plueckthun A]]	+	[[Category: Plueckthun, A]]
-	[[Category: Schoeppe J]]	+	[[Category: Schoeppe, J]]
-	[[Category: Waltenspuehl Y]]	+	[[Category: Waltenspuehl, Y]]
		+	[[Category: Eukaryotic]]
		+	[[Category: Hormone receptor]]
		+	[[Category: Protein]]

OCA at 05:33, 5 August 2020

OCA — Wed, 05 Aug 2020 05:33:33 GMT

←Older revision		Revision as of 05:33, 5 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6tpk is ~~ON HOLD until Dec 13 2021~~	+	==Structure of a Eukaryotic Protein==
-		+	<StructureSection load='6tpk' size='340' side='right'caption='[[6tpk]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TPK FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpk OCA], [http://pdbe.org/6tpk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tpk RCSB], [http://www.ebi.ac.uk/pdbsum/6tpk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ehrenmann J]]
		+	[[Category: Kummer L]]
		+	[[Category: Plueckthun A]]
		+	[[Category: Schoeppe J]]
		+	[[Category: Waltenspuehl Y]]

OCA at 06:20, 22 July 2020

OCA — Wed, 22 Jul 2020 06:20:09 GMT

←Older revision		Revision as of 06:20, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tpk is ON HOLD	+	The entry 6tpk is ON HOLD until Dec 13 2021

	Authors:		Authors:

OCA: Protected "6tpk" [edit=sysop:move=sysop]

OCA — Wed, 25 Dec 2019 07:19:16 GMT

Protected "6tpk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 25 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tpk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Dec 2019 07:19:14 GMT

New page: '''Unreleased structure''' The entry 6tpk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tpk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]