6tsf - Revision history

OCA at 13:08, 24 January 2024

OCA — Wed, 24 Jan 2024 13:08:26 GMT

←Older revision		Revision as of 13:08, 24 January 2024
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	<StructureSection load='6tsf' size='340' side='right'caption='[[6tsf]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='6tsf' size='340' side='right'caption='[[6tsf]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tsf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TSF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~, ~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6tsa\|6tsa]], [[6tr9\|6tr9]], [[6ts0\|6ts0]], [[6ts1\|6ts1]], [[6trz\|6trz]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
-	<~~tr id~~='~~gene~~'><~~td class="sblockLbl"~~><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsf OCA], [https://pdbe.org/6tsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tsf RCSB], [https://www.ebi.ac.uk/pdbsum/6tsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsf OCA], [~~http~~://pdbe.org/6tsf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tsf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tsf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[~~http~~://omim.org/entry/600886 600886]]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[~~http~~://omim.org/entry/606159 606159]]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>	+	[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[https://omim.org/entry/600886 600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[https://omim.org/entry/606159 606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>	+	[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 6tsf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6tsf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ciambellotti, S]]	+	[[Category: Ciambellotti S]]
-	[[Category: Mangani, S]]	+	[[Category: Mangani S]]
-	[[Category: Pozzi, C]]	+	[[Category: Pozzi C]]
-	[[Category: Turano, P]]	+	[[Category: Turano P]]
-	~~[[Category: Hulf]]~~	+
-	~~[[Category: Human l ferritin]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 06:08, 20 May 2020

OCA — Wed, 20 May 2020 06:08:13 GMT

←Older revision		Revision as of 06:08, 20 May 2020
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	<StructureSection load='6tsf' size='340' side='right'caption='[[6tsf]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='6tsf' size='340' side='right'caption='[[6tsf]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tsf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TSF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6tsa\|6tsa]], [[6tr9\|6tr9]], [[6ts0\|6ts0]], [[6ts1\|6ts1]], [[6trz\|6trz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6tsa\|6tsa]], [[6tr9\|6tr9]], [[6ts0\|6ts0]], [[6ts1\|6ts1]], [[6trz\|6trz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6tsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsf OCA], [http://pdbe.org/6tsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsf RCSB], [http://www.ebi.ac.uk/pdbsum/6tsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsf ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsf OCA], [http://pdbe.org/6tsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsf RCSB], [http://www.ebi.ac.uk/pdbsum/6tsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ciambellotti, S]]		[[Category: Ciambellotti, S]]

OCA at 06:39, 19 February 2020

OCA — Wed, 19 Feb 2020 06:39:43 GMT

←Older revision		Revision as of 06:39, 19 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tsf is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of human L ferritin (HuLf) Fe(III)-loaded for 60 minutes==
		+	<StructureSection load='6tsf' size='340' side='right'caption='[[6tsf]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6tsf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TSF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6tsa\|6tsa]], [[6tr9\|6tr9]], [[6ts0\|6ts0]], [[6ts1\|6ts1]], [[6trz\|6trz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsf OCA], [http://pdbe.org/6tsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsf RCSB], [http://www.ebi.ac.uk/pdbsum/6tsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsf ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[http://omim.org/entry/600886 600886]]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[http://omim.org/entry/606159 606159]]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	X-ray structures of homopolymeric human L-ferritin and horse spleen ferritin were solved by freezing protein crystals at different time intervals after exposure to a ferric salt and revealed the growth of an octa-nuclear iron cluster on the inner surface of the protein cage with a key role played by some glutamate residues. An atomic resolution view of how the cluster formation develops starting from a (mu 3 -oxo)tris[(mu 2 -glutamato-kappaO:kappaO')](glutamato-kappaO)(diaquo)triiron(III) seed is provided. The results support the idea that iron biomineralization in ferritin is a process initiating at the level of the protein surface, capable of contributing coordination bonds and electrostatic guidance.

-	~~Authors: Pozzi, C~~., Ciambellotti, S., Turano, P.~~, Mangani, S~~.	+	Iron biomineral growth from the initial nucleation seed in L-ferritin.,Ciambellotti S, Pozzi C, Mangani S, Turano P Chemistry. 2020 Feb 6. doi: 10.1002/chem.202000064. PMID:32027764<ref>PMID:32027764</ref>

-	~~Description: Crystal structure~~ of ~~human L ferritin (HuLf) Fe(III)-loaded for 60 minutes~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Mangani, S~~]]	+	<div class="pdbe-citations 6tsf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ciambellotti, S]]		[[Category: Ciambellotti, S]]
-	[[Category: ~~Turano~~, P]]	+	[[Category: Mangani, S]]
	[[Category: Pozzi, C]]		[[Category: Pozzi, C]]
		+	[[Category: Turano, P]]
		+	[[Category: Hulf]]
		+	[[Category: Human l ferritin]]
		+	[[Category: Metal binding protein]]

OCA at 06:01, 8 January 2020

OCA — Wed, 08 Jan 2020 06:01:56 GMT

←Older revision		Revision as of 06:01, 8 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tsf is ON HOLD	+	The entry 6tsf is ON HOLD until Paper Publication

	Authors: Pozzi, C., Ciambellotti, S., Turano, P., Mangani, S.		Authors: Pozzi, C., Ciambellotti, S., Turano, P., Mangani, S.

OCA: Protected "6tsf" [edit=sysop:move=sysop]

OCA — Wed, 01 Jan 2020 06:44:02 GMT

Protected "6tsf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 1 January 2020

OCA: New page: '''Unreleased structure''' The entry 6tsf is ON HOLD Authors: Pozzi, C., Ciambellotti, S., Turano, P., Mangani, S. Description: Crystal structure of human L ferritin (HuLf) Fe(III)-loa...

OCA — Wed, 01 Jan 2020 06:44:01 GMT

New page: '''Unreleased structure''' The entry 6tsf is ON HOLD Authors: Pozzi, C., Ciambellotti, S., Turano, P., Mangani, S. Description: Crystal structure of human L ferritin (HuLf) Fe(III)-loa...

New page

'''Unreleased structure'''

The entry 6tsf is ON HOLD

Authors: Pozzi, C., Ciambellotti, S., Turano, P., Mangani, S.

Description: Crystal structure of human L ferritin (HuLf) Fe(III)-loaded for 60 minutes
[[Category: Unreleased Structures]]
[[Category: Mangani, S]]
[[Category: Ciambellotti, S]]
[[Category: Turano, P]]
[[Category: Pozzi, C]]