6tsl - Revision history

OCA at 13:08, 24 January 2024

OCA — Wed, 24 Jan 2024 13:08:31 GMT

←Older revision		Revision as of 13:08, 24 January 2024
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-	====	+	==Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS synthetic substrate==
-	<StructureSection load='6tsl' size='340' side='right'caption='[[6tsl]]' scene=''>	+	<StructureSection load='6tsl' size='340' side='right'caption='[[6tsl]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Marasmius_oreades Marasmius oreades] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TSL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsl OCA], [https://pdbe.org/6tsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tsl RCSB], [https://www.ebi.ac.uk/pdbsum/6tsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsl OCA], [https://pdbe.org/6tsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tsl RCSB], [https://www.ebi.ac.uk/pdbsum/6tsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8X123_9AGAR Q8X123_9AGAR]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Marasmius oreades agglutinin (MOA) is the holotype of an emerging family of fungal chimerolectins and an active Ca(2+)/Mn(2+)-dependent protease, which exhibits a unique papain-like fold with special active site features. Here we investigated the functional significance of the structural elements differentiating MOA from other papain-like cysteine proteases. X-ray crystal structures of MOA co-crystallized with two synthetic substrates reveal cleaved peptides bound to the catalytic site, corresponding to the final products of the proteolytic reaction. Anomalous diffraction data on crystals grown in the presence of calcium and manganese, cadmium or zinc resolve the calcium/manganese preference of MOA and elucidate the inhibitory roles of zinc and cadmium towards papain-like cysteine proteases in general. The reported structures, together with activity data of MOA active site variants, point to a conservation of the general proteolysis mechanism established for papain. Ultimately, the findings suggest that papain and the papain-like domain of MOA are the product of convergent evolution.
		+
		+	Crystal structure of MOA in complex with a peptide fragment: A protease caught in flagranti.,Manna D, Cordara G, Krengel U Curr Res Struct Biol. 2020 Apr 22;2:56-67. doi: 10.1016/j.crstbi.2020.04.003., eCollection 2020. PMID:34235469<ref>PMID:34235469</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tsl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Agglutinin 3D structures\|Agglutinin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Marasmius oreades]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Cordara G]]
		+	[[Category: Krengel U]]
		+	[[Category: Manna D]]

OCA at 09:05, 21 July 2021

OCA — Wed, 21 Jul 2021 09:05:43 GMT

←Older revision		Revision as of 09:05, 21 July 2021
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	<StructureSection load='6tsl' size='340' side='right'caption='[[6tsl]]' scene=''>		<StructureSection load='6tsl' size='340' side='right'caption='[[6tsl]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsl OCA], [~~http~~://pdbe.org/6tsl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tsl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tsl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsl ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsl OCA], [https://pdbe.org/6tsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tsl RCSB], [https://www.ebi.ac.uk/pdbsum/6tsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsl ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 11:08, 29 July 2020

OCA — Wed, 29 Jul 2020 11:08:46 GMT

←Older revision		Revision as of 11:08, 29 July 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tsl ~~is ON HOLD~~	+	====
-		+	<StructureSection load='6tsl' size='340' side='right'caption='[[6tsl]]' scene=''>
-	~~Authors~~: ~~Cordara, G~~.~~, Manna, D~~.~~, Krengel, U~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Marasmius oreades agglutinin (MOA) in complex with~~ the ~~truncated PVPRAHS synthetic substrate~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tsl OCA], [http://pdbe.org/6tsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tsl RCSB], [http://www.ebi.ac.uk/pdbsum/6tsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tsl ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Cordara~~, G]]	+	__TOC__
-	[[Category: ~~Krengel, U~~]]	+	</StructureSection>
-	[[Category: ~~Manna, D~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:22, 22 July 2020

OCA — Wed, 22 Jul 2020 06:22:44 GMT

←Older revision		Revision as of 06:22, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tsl is ON HOLD ~~until Paper Publication~~	+	The entry 6tsl is ON HOLD

	Authors: Cordara, G., Manna, D., Krengel, U.		Authors: Cordara, G., Manna, D., Krengel, U.

OCA at 02:37, 13 February 2020

OCA — Thu, 13 Feb 2020 02:37:48 GMT

←Older revision		Revision as of 02:37, 13 February 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tsl is ON HOLD	+	The entry 6tsl is ON HOLD until Paper Publication

	Authors: Cordara, G., Manna, D., Krengel, U.		Authors: Cordara, G., Manna, D., Krengel, U.
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	Description: Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS synthetic substrate		Description: Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS synthetic substrate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Cordara, G]]
	[[Category: Krengel, U]]		[[Category: Krengel, U]]
	[[Category: Manna, D]]		[[Category: Manna, D]]
-	[[Category: Cordara, G]]

OCA: Protected "6tsl" [edit=sysop:move=sysop]

OCA — Wed, 01 Jan 2020 06:44:35 GMT

Protected "6tsl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 1 January 2020

OCA: New page: '''Unreleased structure''' The entry 6tsl is ON HOLD Authors: Cordara, G., Manna, D., Krengel, U. Description: Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS ...

OCA — Wed, 01 Jan 2020 06:44:33 GMT

New page: '''Unreleased structure''' The entry 6tsl is ON HOLD Authors: Cordara, G., Manna, D., Krengel, U. Description: Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS ...

New page

'''Unreleased structure'''

The entry 6tsl is ON HOLD

Authors: Cordara, G., Manna, D., Krengel, U.

Description: Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS synthetic substrate
[[Category: Unreleased Structures]]
[[Category: Krengel, U]]
[[Category: Manna, D]]
[[Category: Cordara, G]]