OCA at 10:19, 22 May 2024

OCA — Wed, 22 May 2024 10:19:05 GMT

←Older revision		Revision as of 10:19, 22 May 2024
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-	====	+	==Ovine ATP synthase 1a state==
-	<StructureSection load='6tt7' size='340' side='right'caption='[[6tt7]]' scene=''>	+	<StructureSection load='6tt7' size='340' side='right'caption='[[6tt7]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tt7]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TT7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tt7 OCA], [~~http~~://pdbe.org/6tt7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tt7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tt7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tt7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene>, <scene name='pdbligand=S12:O-[(S)-HYDROXY{[(2S)-2-HYDROXY-3-(OCTADEC-9-ENOYLOXY)PROPYL]OXY}PHOSPHORYL]-L-SERINE'>S12</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tt7 OCA], [https://pdbe.org/6tt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tt7 RCSB], [https://www.ebi.ac.uk/pdbsum/6tt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tt7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATPG_BOVIN ATPG_BOVIN] Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The majority of adenosine triphosphate (ATP) powering cellular processes in eukaryotes is produced by the mitochondrial F1Fo ATP synthase. Here, we present the atomic models of the membrane Fo domain and the entire mammalian (ovine) F1Fo, determined by cryo-electron microscopy. Subunits in the membrane domain are arranged in the 'proton translocation cluster' attached to the c-ring and a more distant 'hook apparatus' holding subunit e. Unexpectedly, this subunit is anchored to a lipid 'plug' capping the c-ring. We present a detailed proton translocation pathway in mammalian Fo and key inter-monomer contacts in F1Fo multimers. Cryo-EM maps of F1Fo exposed to calcium reveal a retracted subunit e and a disassembled c-ring, suggesting permeability transition pore opening. We propose a model for the permeability transition pore opening, whereby subunit e pulls the lipid plug out of the c-ring. Our structure will allow the design of drugs for many emerging applications in medicine.
		+
		+	Cryo-EM structure of the entire mammalian F-type ATP synthase.,Pinke G, Zhou L, Sazanov LA Nat Struct Mol Biol. 2020 Sep 14. pii: 10.1038/s41594-020-0503-8. doi:, 10.1038/s41594-020-0503-8. PMID:32929284<ref>PMID:32929284</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tt7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase 3D structures\|ATPase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Ovis aries]]
		+	[[Category: Pinke G]]
		+	[[Category: Sazanov LA]]
		+	[[Category: Zhou L]]

OCA at 11:10, 23 September 2020

OCA — Wed, 23 Sep 2020 11:10:16 GMT

←Older revision		Revision as of 11:10, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6tt7 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6tt7' size='340' side='right'caption='[[6tt7]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tt7 OCA], [http://pdbe.org/6tt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tt7 RCSB], [http://www.ebi.ac.uk/pdbsum/6tt7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tt7 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 10:35, 8 July 2020

OCA — Wed, 08 Jul 2020 10:35:58 GMT

←Older revision		Revision as of 10:35, 8 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tt7 is ON HOLD	+	The entry 6tt7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6tt7" [edit=sysop:move=sysop]

OCA — Wed, 01 Jan 2020 06:46:07 GMT

Protected "6tt7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:46, 1 January 2020

OCA: New page: '''Unreleased structure''' The entry 6tt7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jan 2020 06:46:06 GMT

New page: '''Unreleased structure''' The entry 6tt7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tt7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6tt7 - Revision history

OCA at 10:19, 22 May 2024

OCA at 11:10, 23 September 2020

OCA at 10:35, 8 July 2020

OCA: Protected "6tt7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6tt7 is ON HOLD Authors: Description: Category: Unreleased Structures