6tu2 - Revision history

OCA at 13:09, 24 January 2024

OCA — Wed, 24 Jan 2024 13:09:25 GMT

←Older revision		Revision as of 13:09, 24 January 2024
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	<StructureSection load='6tu2' size='340' side='right'caption='[[6tu2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6tu2' size='340' side='right'caption='[[6tu2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tu2]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TU2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tu2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TU2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Anxa11, rCG_39189 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tu2 OCA], [~~http~~://pdbe.org/6tu2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tu2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tu2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tu2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tu2 OCA], [https://pdbe.org/6tu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tu2 RCSB], [https://www.ebi.ac.uk/pdbsum/6tu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tu2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5XI77_RAT Q5XI77_RAT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6tu2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6tu2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Annexin 3D structures\|Annexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kursula, P~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Lillebostad,~~ P]]	+	[[Category: Kursula P]]
-	[[Category: ~~Raasakka, A~~]]	+	[[Category: Lillebostad P]]
-	[[Category: ~~Vedeler,~~ A]]	+	[[Category: Raasakka A]]
-	[[Category: ~~Annexin]]~~	+	[[Category: Vedeler A]]
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Core domain]]~~	+
-	~~[[Category: Lipid binding protein~~]]	+

OCA at 09:50, 18 November 2020

OCA — Wed, 18 Nov 2020 09:50:59 GMT

←Older revision		Revision as of 09:50, 18 November 2020
Line 1:		Line 1:

	==Crystal structure of rat annexin A11==		==Crystal structure of rat annexin A11==
-	<StructureSection load='6tu2' size='340' side='right'caption='[[6tu2]]' scene=''>	+	<StructureSection load='6tu2' size='340' side='right'caption='[[6tu2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TU2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tu2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TU2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TU2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tu2 OCA], [http://pdbe.org/6tu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tu2 RCSB], [http://www.ebi.ac.uk/pdbsum/6tu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tu2 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anxa11, rCG_39189 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tu2 OCA], [http://pdbe.org/6tu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tu2 RCSB], [http://www.ebi.ac.uk/pdbsum/6tu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tu2 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The functions of the annexin family of proteins involve binding to Ca(2+), lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long N-terminal region, which is predicted to be disordered, binds RNA, and forms membraneless organelles involved in neuronal transport. Mutations in AnxA11 have been linked to amyotrophic lateral sclerosis (ALS). We studied the structure and stability of AnxA11 and identified a short stabilising segment in the N-terminal end of the folded core, which links domains I and IV. The crystal structure of the AnxA11 core highlights main-chain hydrogen bonding interactions formed through this bridging segment, which are likely conserved in most annexins. The structure was also used to study the currently known ALS mutations in AnxA11. Three of these mutations correspond to buried Arg residues highly conserved in the annexin family, indicating central roles in annexin folding. The structural data provide starting points for detailed structure-function studies of both full-length AnxA11 and the disease variants being identified in ALS.
		+
		+	Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.,Lillebostad PAG, Raasakka A, Hjellbrekke SJ, Patil S, Rostbo T, Hollas H, Sakya SA, Szigetvari PD, Vedeler A, Kursula P Biomolecules. 2020 Apr 24;10(4). pii: biom10040660. doi: 10.3390/biom10040660. PMID:32344647<ref>PMID:32344647</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tu2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kursula P]]	+	[[Category: Kursula, P]]
-	[[Category: Lillebostad P]]	+	[[Category: Lillebostad, P]]
-	[[Category: Raasakka A]]	+	[[Category: Raasakka, A]]
-	[[Category: Vedeler A]]	+	[[Category: Vedeler, A]]
		+	[[Category: Annexin]]
		+	[[Category: Calcium]]
		+	[[Category: Core domain]]
		+	[[Category: Lipid binding protein]]

OCA at 06:03, 6 May 2020

OCA — Wed, 06 May 2020 06:03:46 GMT

←Older revision		Revision as of 06:03, 6 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6tu2 is ~~ON HOLD~~	+	==Crystal structure of rat annexin A11==
-		+	<StructureSection load='6tu2' size='340' side='right'caption='[[6tu2]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TU2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TU2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tu2 OCA], [http://pdbe.org/6tu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tu2 RCSB], [http://www.ebi.ac.uk/pdbsum/6tu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tu2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kursula P]]
		+	[[Category: Lillebostad P]]
		+	[[Category: Raasakka A]]
		+	[[Category: Vedeler A]]

OCA: Protected "6tu2" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2020 06:05:09 GMT

Protected "6tu2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 8 January 2020

OCA: New page: '''Unreleased structure''' The entry 6tu2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jan 2020 06:05:07 GMT

New page: '''Unreleased structure''' The entry 6tu2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tu2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]