6tvq - Revision history

OCA at 06:17, 19 July 2023

OCA — Wed, 19 Jul 2023 06:17:30 GMT

←Older revision		Revision as of 06:17, 19 July 2023
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-	====	+	==Structure of native gp41 derived peptide fusion inhibitor==
-	<StructureSection load='6tvq' size='340' side='right'caption='[[6tvq]]' scene=''>	+	<StructureSection load='6tvq' size='340' side='right'caption='[[6tvq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TVQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tvq OCA], [https://pdbe.org/6tvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tvq RCSB], [https://www.ebi.ac.uk/pdbsum/6tvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tvq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tvq OCA], [https://pdbe.org/6tvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tvq RCSB], [https://www.ebi.ac.uk/pdbsum/6tvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tvq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5VGF0_9HIV1 Q5VGF0_9HIV1]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	With the emergence of novel viruses, the development of new antivirals is more urgent than ever. A key step in human immunodeficiency virus type 1 (HIV-1) infection is six-helix bundle formation within the envelope protein subunit gp41. Selective disruption of bundle formation by peptides has been shown to be effective; however, these drugs, exemplified by T20, are prone to rapid clearance from the patient. The incorporation of non-natural amino acids is known to improve these pharmacokinetic properties. Here, we evaluate a peptide inhibitor in which a critical Ile residue is replaced by fluorinated analogues. We characterized the influence of the fluorinated analogues on the biophysical properties of the peptide. Furthermore, we show that the fluorinated peptides can block HIV-1 infection of target cells at nanomolar levels. These findings demonstrate that fluorinated amino acids are appropriate tools for the development of novel peptide therapeutics.
		+
		+	Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection.,Huhmann S, Nyakatura EK, Rohrhofer A, Moschner J, Schmidt B, Eichler J, Roth C, Koksch B Chembiochem. 2021 Dec 10;22(24):3443-3451. doi: 10.1002/cbic.202100417. Epub 2021 , Oct 22. PMID:34605595<ref>PMID:34605595</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tvq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Eichler J]]
		+	[[Category: Huhmann S]]
		+	[[Category: Moschner J]]
		+	[[Category: Nyakatura EK]]
		+	[[Category: Rohrhofer A]]
		+	[[Category: Roth C]]
		+	[[Category: Schmidt B]]

OCA at 07:53, 27 January 2021

OCA — Wed, 27 Jan 2021 07:53:30 GMT

←Older revision		Revision as of 07:53, 27 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6tvq ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6tvq' size='340' side='right'caption='[[6tvq]]' scene=''>
-	~~Authors~~: ~~Huhmann, S~~.~~, Nyakatura, E~~.K.~~, Rohrhofer, A~~.~~, Schmidt, B~~.~~, Eichler, J~~.~~, Moschner, J., Roth, C~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structure of native gp41 derived peptide fusion inhibitor~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tvq OCA], [https://pdbe.org/6tvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tvq RCSB], [https://www.ebi.ac.uk/pdbsum/6tvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tvq ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Schmidt~~, ~~B]]~~	+	__TOC__
-	[~~[Category~~: ~~Moschner, J~~]]	+	</StructureSection>
-	[~~[Category~~: ~~Huhmann~~, ~~S]]~~	+	[[Category: Large Structures]]
-	[~~[Category~~: ~~Rohrhofer~~, ~~A]]~~	+	[[Category: Z-disk]]
-	[~~[Category~~: ~~Eichler, J]~~]	+
-	[[Category: ~~Roth, C~~]]	+
-	[[Category: ~~Nyakatura, E.K~~]]	+

OCA at 13:18, 29 January 2020

OCA — Wed, 29 Jan 2020 13:18:05 GMT

←Older revision		Revision as of 13:18, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tvq is ON HOLD	+	The entry 6tvq is ON HOLD until Paper Publication

	Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C.		Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Schmidt, B]]		[[Category: Schmidt, B]]
		+	[[Category: Moschner, J]]
	[[Category: Huhmann, S]]		[[Category: Huhmann, S]]
	[[Category: Rohrhofer, A]]		[[Category: Rohrhofer, A]]
-	[[Category: Roth, C]]
-	[[Category: Moschner, J]]
	[[Category: Eichler, J]]		[[Category: Eichler, J]]
		+	[[Category: Roth, C]]
	[[Category: Nyakatura, E.K]]		[[Category: Nyakatura, E.K]]

OCA: Protected "6tvq" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2020 13:59:09 GMT

Protected "6tvq" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:59, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6tvq is ON HOLD Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C. Description: Structure of na...

OCA — Wed, 22 Jan 2020 13:59:07 GMT

New page: '''Unreleased structure''' The entry 6tvq is ON HOLD Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C. Description: Structure of na...

New page

'''Unreleased structure'''

The entry 6tvq is ON HOLD

Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C.

Description: Structure of native gp41 derived peptide fusion inhibitor
[[Category: Unreleased Structures]]
[[Category: Schmidt, B]]
[[Category: Huhmann, S]]
[[Category: Rohrhofer, A]]
[[Category: Roth, C]]
[[Category: Moschner, J]]
[[Category: Eichler, J]]
[[Category: Nyakatura, E.K]]