6txl - Revision history

OCA at 13:11, 24 January 2024

OCA — Wed, 24 Jan 2024 13:11:46 GMT

←Older revision		Revision as of 13:11, 24 January 2024
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	<StructureSection load='6txl' size='340' side='right'caption='[[6txl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6txl' size='340' side='right'caption='[[6txl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6txl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thema Thema~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6txl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.099Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TM_1128 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bacterial_non-heme_ferritin Bacterial non-heme ferritin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.2 1.16.3.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txl OCA], [https://pdbe.org/6txl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txl RCSB], [https://www.ebi.ac.uk/pdbsum/6txl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txl OCA], [https://pdbe.org/6txl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txl RCSB], [https://www.ebi.ac.uk/pdbsum/6txl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA]] Iron storage protein (By similarity).[RuleBase:RU361145]	+	[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA] Iron storage protein (By similarity).[RuleBase:RU361145]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6txl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6txl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacterial non-heme ferritin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thema~~]]	+	[[Category: Thermotoga maritima MSB8]]
-	[[Category: Chakraborti, S]]	+	[[Category: Chakraborti S]]
-	[[Category: Grudnik, P]]	+	[[Category: Grudnik P]]
-	[[Category: Heddle, J]]	+	[[Category: Heddle J]]
-	[[Category: Kumar, M]]	+	[[Category: Kumar M]]
-	[[Category: Wilk, P]]	+	[[Category: Wilk P]]
-	~~[[Category: Engineered protein]]~~	+
-	~~[[Category: Metal binding]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 05:05, 10 August 2022

OCA — Wed, 10 Aug 2022 05:05:18 GMT

←Older revision		Revision as of 05:05, 10 August 2022
Line 1:		Line 1:

	==Crystal structure of thermotoga maritima E65Q Ferritin==		==Crystal structure of thermotoga maritima E65Q Ferritin==
-	<StructureSection load='6txl' size='340' side='right'caption='[[6txl]]' scene=''>	+	<StructureSection load='6txl' size='340' side='right'caption='[[6txl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6txl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txl OCA], [https://pdbe.org/6txl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txl RCSB], [https://www.ebi.ac.uk/pdbsum/6txl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txl ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TM_1128 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bacterial_non-heme_ferritin Bacterial non-heme ferritin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.2 1.16.3.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txl OCA], [https://pdbe.org/6txl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txl RCSB], [https://www.ebi.ac.uk/pdbsum/6txl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA]] Iron storage protein (By similarity).[RuleBase:RU361145]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cage forming proteins have numerous potential applications in biomedicine and biotechnology, where the iron storage ferritin is a widely used example. However, controlling ferritin cage assembly/disassembly remains challenging, typically requiring extreme conditions incompatible with many desirable cargoes, particularly for more fragile biopharmaceuticals. Recently, a ferritin from the hyperthermophile bacterium Thermotoga maritima (TmFtn) has been shown to have reversible assembly under mild conditions, offering greater potential biocompatibility in terms of cargo access and encapsulation. Like Archeoglobus fulgidus ferritin (AfFtn), TmFtn forms 24mer cages mediated by metal ions (Mg2+). We have solved the crystal structure of the wild type TmFtn and several mutants displaying different assembly/disassembly properties. These data combined with other biophysical studies allow us to suggest candidate interfacial amino acids crucial in controlling assembly. This work deepens our understanding of how these ferritin complexes assemble and is a useful step towards production of triggerable ferritins in which these properties can be finely designed and controlled.
		+
		+	A single residue can modulate nanocage assembly in salt dependent ferritin.,Kumar M, Markiewicz-Mizera J, Janna Olmos JD, Wilk P, Grudnik P, Biela AP, Jemiola-Rzeminska M, Gorecki A, Chakraborti S, Heddle JG Nanoscale. 2021 Jul 15;13(27):11932-11942. doi: 10.1039/d1nr01632f. PMID:34195748<ref>PMID:34195748</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6txl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterial non-heme ferritin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chakraborti S]]	+	[[Category: Thema]]
-	[[Category: Grudnik P]]	+	[[Category: Chakraborti, S]]
-	[[Category: Heddle J]]	+	[[Category: Grudnik, P]]
-	[[Category: Kumar M]]	+	[[Category: Heddle, J]]
-	[[Category: Wilk P]]	+	[[Category: Kumar, M]]
		+	[[Category: Wilk, P]]
		+	[[Category: Engineered protein]]
		+	[[Category: Metal binding]]
		+	[[Category: Metal binding protein]]

OCA at 10:30, 28 July 2021

OCA — Wed, 28 Jul 2021 10:30:57 GMT

←Older revision		Revision as of 10:30, 28 July 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6txl ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of thermotoga maritima E65Q Ferritin==
-		+	<StructureSection load='6txl' size='340' side='right'caption='[[6txl]]' scene=''>
-	~~Authors~~: ~~Wilk, P~~., ~~Grudnik~~, P., ~~Kumar, M~~., ~~Heddle, J~~., ~~Chakraborti, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXL FirstGlance]. <br>
-	~~Description: Crystal structure of thermotoga maritima E65Q Ferritin~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txl OCA], [https://pdbe.org/6txl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txl RCSB], [https://www.ebi.ac.uk/pdbsum/6txl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txl ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Chakraborti, S]]	+	__TOC__
-	[[Category: ~~Wilk,~~ P]]	+	</StructureSection>
-	[[Category: ~~Grudnik, P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Heddle, J~~]]	+	[[Category: Chakraborti S]]
-	[[Category: ~~Kumar, M~~]]	+	[[Category: Grudnik P]]
		+	[[Category: Heddle J]]
		+	[[Category: Kumar M]]
		+	[[Category: Wilk P]]

OCA at 05:30, 8 April 2020

OCA — Wed, 08 Apr 2020 05:30:30 GMT

←Older revision		Revision as of 05:30, 8 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6txl is ON HOLD	+	The entry 6txl is ON HOLD until Paper Publication

	Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S.		Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S.

-	Description: Crystal structure of thermotoga maritima ~~E65A~~ Ferritin	+	Description: Crystal structure of thermotoga maritima E65Q Ferritin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Chakraborti, S]]
	[[Category: Wilk, P]]		[[Category: Wilk, P]]
	[[Category: Grudnik, P]]		[[Category: Grudnik, P]]
-	[[Category: Kumar, M]]
-	[[Category: Chakraborti, S]]
	[[Category: Heddle, J]]		[[Category: Heddle, J]]
		+	[[Category: Kumar, M]]

OCA: Protected "6txl" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2020 14:05:46 GMT

Protected "6txl" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:05, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6txl is ON HOLD Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S. Description: Crystal structure of thermotoga maritima E65A F...

OCA — Wed, 22 Jan 2020 14:05:44 GMT

New page: '''Unreleased structure''' The entry 6txl is ON HOLD Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S. Description: Crystal structure of thermotoga maritima E65A F...

New page

'''Unreleased structure'''

The entry 6txl is ON HOLD

Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S.

Description: Crystal structure of thermotoga maritima E65A Ferritin
[[Category: Unreleased Structures]]
[[Category: Wilk, P]]
[[Category: Grudnik, P]]
[[Category: Kumar, M]]
[[Category: Chakraborti, S]]
[[Category: Heddle, J]]