OCA at 07:41, 11 October 2023

OCA — Wed, 11 Oct 2023 07:41:27 GMT

←Older revision		Revision as of 07:41, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6tzy' size='340' side='right'caption='[[6tzy]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6tzy' size='340' side='right'caption='[[6tzy]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tzy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TZY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tzy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TZY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6tzz\|6tzz]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6tzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tzy OCA], [~~http~~://pdbe.org/6tzy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tzy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tzy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tzy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tzy OCA], [https://pdbe.org/6tzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tzy RCSB], [https://www.ebi.ac.uk/pdbsum/6tzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tzy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/I7MFJ3_TETTS I7MFJ3_TETTS]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Inactivating mutations cause rhabdomyolysis, autoinflammatory disease, and aberrant fat storage. Disease-mutations cluster within the conserved N-Lip and C-Lip regions that are separated by 500-residues in humans. To understand how the N-Lip and C-Lip combine for PAP function, we determined crystal structures of Tetrahymena thermophila Pah2 (Tt Pah2) that directly fuses the N-Lip and C-Lip. Tt Pah2 adopts a two-domain architecture where the N-Lip combines with part of the C-Lip to form an immunoglobulin-like domain and the remaining C-Lip forms a HAD-like catalytic domain. An N-Lip C-Lip fusion of mouse lipin-2 is catalytically active, which suggests mammalian lipins function with the same domain architecture as Tt Pah2. HDX-MS identifies an N-terminal amphipathic helix essential for membrane association. Disease-mutations disrupt catalysis or destabilize the protein fold. This illustrates mechanisms for lipin/Pah PAP function, membrane association, and lipin-related pathologies.
		+
		+	Crystal structure of a lipin/Pah phosphatidic acid phosphatase.,Khayyo VI, Hoffmann RM, Wang H, Bell JA, Burke JE, Reue K, Airola MV Nat Commun. 2020 Mar 11;11(1):1309. doi: 10.1038/s41467-020-15124-z. PMID:32161260<ref>PMID:32161260</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tzy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Airola, M V~~]]	+	[[Category: Tetrahymena thermophila]]
-	[[Category: ~~Khayyo, V I~~]]	+	[[Category: Airola MV]]
-	[[Category: ~~Haloacid dehalogenase]]~~	+	[[Category: Khayyo VI]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Immunoglobulin-like]]~~	+
-	~~[[Category: Lipin]]~~	+
-	~~[[Category: Phosphatidic acid phosphatase~~]]	+

OCA at 09:55, 18 March 2020

OCA — Wed, 18 Mar 2020 09:55:38 GMT

←Older revision		Revision as of 09:55, 18 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tzy ~~is ON HOLD~~	+	==Crystal Structure of a lipin/Pah Phosphatidic Acid Phosphatase==
-		+	<StructureSection load='6tzy' size='340' side='right'caption='[[6tzy]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6tzy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TZY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6tzz\|6tzz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tzy OCA], [http://pdbe.org/6tzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tzy RCSB], [http://www.ebi.ac.uk/pdbsum/6tzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tzy ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Airola, M V]]
		+	[[Category: Khayyo, V I]]
		+	[[Category: Haloacid dehalogenase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Immunoglobulin-like]]
		+	[[Category: Lipin]]
		+	[[Category: Phosphatidic acid phosphatase]]

OCA: Protected "6tzy" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2019 04:26:27 GMT

Protected "6tzy" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 21 August 2019

OCA: New page: '''Unreleased structure''' The entry 6tzy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Aug 2019 04:26:26 GMT

New page: '''Unreleased structure''' The entry 6tzy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tzy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6tzy - Revision history

OCA at 07:41, 11 October 2023

OCA at 09:55, 18 March 2020

OCA: Protected "6tzy" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6tzy is ON HOLD Authors: Description: Category: Unreleased Structures