6u04 - Revision history

OCA at 07:41, 11 October 2023

OCA — Wed, 11 Oct 2023 07:41:32 GMT

←Older revision		Revision as of 07:41, 11 October 2023
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	<StructureSection load='6u04' size='340' side='right'caption='[[6u04]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6u04' size='340' side='right'caption='[[6u04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u04]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U04 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U04 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PR:PRASEODYMIUM+ION'>PR</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BRPF1, BR140 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u04 OCA], [~~http~~://pdbe.org/6u04 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u04 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u04 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u04 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u04 OCA], [https://pdbe.org/6u04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u04 RCSB], [https://www.ebi.ac.uk/pdbsum/6u04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u04 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> [https://www.uniprot.org/uniprot/H33_HUMAN H33_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Klein~~, B J~~]]	+	[[Category: Klein BJ]]
-	[[Category: Kutateladze~~, T G]]~~	+	[[Category: Kutateladze TG]]
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Epigenetic]]~~	+
-	~~[[Category: Nucleosome]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 16:55, 22 January 2020

OCA — Wed, 22 Jan 2020 16:55:32 GMT

←Older revision		Revision as of 16:55, 22 January 2020
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	<StructureSection load='6u04' size='340' side='right'caption='[[6u04]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6u04' size='340' side='right'caption='[[6u04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u04]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRPF1, BR140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u04 OCA], [http://pdbe.org/6u04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u04 RCSB], [http://www.ebi.ac.uk/pdbsum/6u04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u04 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u04 OCA], [http://pdbe.org/6u04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u04 RCSB], [http://www.ebi.ac.uk/pdbsum/6u04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u04 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Klein, B J]]		[[Category: Klein, B J]]

OCA at 07:01, 27 November 2019

OCA — Wed, 27 Nov 2019 07:01:51 GMT

←Older revision		Revision as of 07:01, 27 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6u04 is ~~ON HOLD~~	+	==Crystal structure of human BRPF1 PZP bound to histone H3 tail==
		+	<StructureSection load='6u04' size='340' side='right'caption='[[6u04]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6u04]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U04 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u04 OCA], [http://pdbe.org/6u04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u04 RCSB], [http://www.ebi.ac.uk/pdbsum/6u04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u04 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The assembly of human histone acetyltransferase MOZ/MORF complexes relies on the scaffolding bromodomain plant homeodomain (PHD) finger 1 (BRPF1) subunit. The PHD-zinc-knuckle-PHD module of BRPF1 (BRPF1PZP) has been shown to associate with the histone H3 tail and DNA; however, the molecular mechanism underlying recognition of H3 and the relationship between the histone and DNA-binding activities remain unclear. In this study, we report the crystal structure of BRPF1PZP bound to the H3 tail and characterize the role of the bipartite interaction in the engagement of BRPF1PZP with the nucleosome core particle (NCP). We find that although both interactions of BRPF1PZP with the H3 tail and DNA are required for tight binding to NCP and for acetyltransferase function of the BRPF1-MORF-ING5-MEAF6 complex, binding to extranucleosomal DNA dominates. Our findings suggest that functionally active BRPF1PZP might be important in stabilization of the MOZ/MORF complexes at chromatin with accessible DNA.

-	~~Authors~~:	+	Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.,Klein BJ, Cox KL, Jang SM, Cote J, Poirier MG, Kutateladze TG Structure. 2019 Nov 6. pii: S0969-2126(19)30355-7. doi:, 10.1016/j.str.2019.10.014. PMID:31711755<ref>PMID:31711755</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6u04" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Klein, B J]]
		+	[[Category: Kutateladze, T G]]
		+	[[Category: Dna binding]]
		+	[[Category: Epigenetic]]
		+	[[Category: Nucleosome]]
		+	[[Category: Transcription]]

OCA: Protected "6u04" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2019 04:27:05 GMT

Protected "6u04" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 21 August 2019

OCA: New page: '''Unreleased structure''' The entry 6u04 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Aug 2019 04:27:03 GMT

New page: '''Unreleased structure''' The entry 6u04 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u04 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]