6u1r - Revision history

OCA at 07:42, 11 October 2023

OCA — Wed, 11 Oct 2023 07:42:37 GMT

←Older revision		Revision as of 07:42, 11 October 2023
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	<StructureSection load='6u1r' size='340' side='right'caption='[[6u1r]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='6u1r' size='340' side='right'caption='[[6u1r]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u1r]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lyngbya_wollei Lyngbya~~ wollei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Microseira_wollei Microseira wollei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=FMT:FORMIC+ACID'>FMT</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.792Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~sxtG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=467598 Lyngbya wollei])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1r OCA], [~~http~~://pdbe.org/6u1r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u1r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u1r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1r OCA], [https://pdbe.org/6u1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1r RCSB], [https://www.ebi.ac.uk/pdbsum/6u1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C3RVP0_9CYAN C3RVP0_9CYAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lyngbya~~ wollei]]	+	[[Category: Microseira wollei]]
-	[[Category: Koutmos, M]]	+	[[Category: Koutmos M]]
-	[[Category: Lukowski~~, A L~~]]	+	[[Category: Lukowski AL]]
-	[[Category: Mallik, L]]	+	[[Category: Mallik L]]
-	[[Category: Narayan~~, A R.H]]~~	+	[[Category: Narayan ARH]]
-	~~[[Category: Amidinotransferase]]~~	+
-	~~[[Category: Saxitoxin biosynthetic pathway]]~~	+
-	~~[[Category: Sxtg]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:45, 1 April 2020

OCA — Wed, 01 Apr 2020 09:45:50 GMT

←Older revision		Revision as of 09:45, 1 April 2020
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	<StructureSection load='6u1r' size='340' side='right'caption='[[6u1r]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='6u1r' size='340' side='right'caption='[[6u1r]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u1r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u1r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lyngbya_wollei Lyngbya wollei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sxtG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=467598 Lyngbya wollei])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1r OCA], [http://pdbe.org/6u1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1r RCSB], [http://www.ebi.ac.uk/pdbsum/6u1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1r OCA], [http://pdbe.org/6u1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1r RCSB], [http://www.ebi.ac.uk/pdbsum/6u1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1r ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lyngbya wollei]]
	[[Category: Koutmos, M]]		[[Category: Koutmos, M]]
	[[Category: Lukowski, A L]]		[[Category: Lukowski, A L]]

OCA at 09:56, 18 March 2020

OCA — Wed, 18 Mar 2020 09:56:05 GMT

←Older revision		Revision as of 09:56, 18 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6u1r is ~~ON HOLD until Paper~~ Publication	+	==SxtG an amidinotransferase from the Microseira wollei in Saxitoxin biosynthetic pathway==
		+	<StructureSection load='6u1r' size='340' side='right'caption='[[6u1r]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6u1r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1r OCA], [http://pdbe.org/6u1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1r RCSB], [http://www.ebi.ac.uk/pdbsum/6u1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1r ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Secondary metabolites are assembled by enzymes that often perform reactions with high selectivity and specificity. Many of these enzymes also tolerate variations in substrate structure, exhibiting promiscuity that enables various applications of a given biocatalyst. However, initial enzyme characterization studies frequently do not explore beyond the native substrates. This limited assessment of substrate scope contributes to the difficulty of identifying appropriate enzymes for specific synthetic applications. Here, we report the natural function of cyanobacterial SxtG, an amidinotransferase involved in the biosynthesis of paralytic shellfish toxins, and demonstrate its ability to modify a breadth of non-native substrates. In addition, we report the first X-ray crystal structure of SxtG, which provides rationale for this enzyme's substrate scope. Taken together, these data confirm the function of SxtG and exemplify its potential utility in biocatalytic synthesis.

-	~~Authors~~:	+	Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase.,Lukowski AL, Mallik L, Hinze ME, Carlson BM, Ellinwood DC, Pyser JB, Koutmos M, Narayan ARH ACS Chem Biol. 2020 Feb 14. doi: 10.1021/acschembio.9b00964. PMID:32058687<ref>PMID:32058687</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6u1r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Koutmos, M]]
		+	[[Category: Lukowski, A L]]
		+	[[Category: Mallik, L]]
		+	[[Category: Narayan, A R.H]]
		+	[[Category: Amidinotransferase]]
		+	[[Category: Saxitoxin biosynthetic pathway]]
		+	[[Category: Sxtg]]
		+	[[Category: Transferase]]

OCA at 13:19, 29 January 2020

OCA — Wed, 29 Jan 2020 13:19:49 GMT

←Older revision		Revision as of 13:19, 29 January 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u1r is ON HOLD	+	The entry 6u1r is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 14:07, 22 January 2020

OCA — Wed, 22 Jan 2020 14:07:35 GMT

←Older revision		Revision as of 14:07, 22 January 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u1r is ON HOLD ~~until Paper Publication~~	+	The entry 6u1r is ON HOLD

	Authors:		Authors:

OCA: Protected "6u1r" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 14:01:27 GMT

Protected "6u1r" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:01, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6u1r is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Aug 2019 14:01:25 GMT

New page: '''Unreleased structure''' The entry 6u1r is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u1r is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]