6u1u - Revision history

OCA at 07:42, 11 October 2023

OCA — Wed, 11 Oct 2023 07:42:40 GMT

←Older revision		Revision as of 07:42, 11 October 2023
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	<StructureSection load='6u1u' size='340' side='right'caption='[[6u1u]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6u1u' size='340' side='right'caption='[[6u1u]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u1u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PLM:PALMITIC+ACID'>PLM</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ANGPTL4, ARP4, HFARP, PGAR, PP1158, PSEC0166, UNQ171/PRO197 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1u OCA], [~~http~~://pdbe.org/6u1u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u1u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u1u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1u OCA], [https://pdbe.org/6u1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1u RCSB], [https://www.ebi.ac.uk/pdbsum/6u1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ANGL4_HUMAN ANGL4_HUMAN]] Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).<ref>PMID:12015030</ref> <ref>PMID:14583458</ref>	+	[https://www.uniprot.org/uniprot/ANGL4_HUMAN ANGL4_HUMAN] Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).<ref>PMID:12015030</ref> <ref>PMID:14583458</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cooper, S]]	+	[[Category: Cooper S]]
-	[[Category: Pusey~~, M L~~]]	+	[[Category: Pusey ML]]
-	[[Category: Ramaker, R]]	+	[[Category: Ramaker R]]
-	[[Category: Singhal~~, A J~~]]	+	[[Category: Singhal AJ]]
-	[[Category: Tarver~~, C L~~]]	+	[[Category: Tarver CL]]
-	[[Category: Yuan, Q]]	+	[[Category: Yuan Q]]
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Cancer cell]]~~	+
-	~~[[Category: Fibrinogen-like domain]]~~	+
-	~~[[Category: Metastasis]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 13:16, 18 December 2019

OCA — Wed, 18 Dec 2019 13:16:45 GMT

←Older revision		Revision as of 13:16, 18 December 2019
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	<StructureSection load='6u1u' size='340' side='right'caption='[[6u1u]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6u1u' size='340' side='right'caption='[[6u1u]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u1u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANGPTL4, ARP4, HFARP, PGAR, PP1158, PSEC0166, UNQ171/PRO197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1u OCA], [http://pdbe.org/6u1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1u RCSB], [http://www.ebi.ac.uk/pdbsum/6u1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1u OCA], [http://pdbe.org/6u1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1u RCSB], [http://www.ebi.ac.uk/pdbsum/6u1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1u ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cooper, S]]		[[Category: Cooper, S]]

OCA at 05:28, 10 October 2019

OCA — Thu, 10 Oct 2019 05:28:30 GMT

←Older revision		Revision as of 05:28, 10 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6u1u is ~~ON HOLD until Paper Publication~~	+	==Human Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) with Palmitic Acid==
-		+	<StructureSection load='6u1u' size='340' side='right'caption='[[6u1u]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors~~: ~~Tarver~~, C.L., ~~Yuan~~, Q., ~~Singhal, A~~.J., ~~Ramaker, R~~., ~~Cooper~~, S., Ng, J., ~~Pusey, M~~.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6u1u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1U FirstGlance]. <br>
-	~~Description: Human Angiopoietin~~-~~Like 4 C-Terminal Domain~~ (~~cANGPTL4~~) ~~with Palmitic Acid~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1u OCA], [http://pdbe.org/6u1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1u RCSB], [http://www.ebi.ac.uk/pdbsum/6u1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1u ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANGL4_HUMAN ANGL4_HUMAN]] Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).<ref>PMID:12015030</ref> <ref>PMID:14583458</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cooper, S]]
		+	[[Category: Pusey, M L]]
	[[Category: Ramaker, R]]		[[Category: Ramaker, R]]
-	[[Category: ~~Tarver, C.L]]~~	+	[[Category: Singhal, A J]]
-	~~[[Category: Cooper, S]]~~	+	[[Category: Tarver, C L]]
-	~~[[Category: Ng~~, J]]	+
-	[[Category: ~~Pusey~~, M.L]]	+
-	~~[[Category: Singhal, A.J~~]]	+
	[[Category: Yuan, Q]]		[[Category: Yuan, Q]]
		+	[[Category: Angiogenesis]]
		+	[[Category: Cancer cell]]
		+	[[Category: Fibrinogen-like domain]]
		+	[[Category: Metastasis]]
		+	[[Category: Signaling protein]]

OCA at 08:06, 2 October 2019

OCA — Wed, 02 Oct 2019 08:06:48 GMT

←Older revision		Revision as of 08:06, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u1u is ON HOLD	+	The entry 6u1u is ON HOLD until Paper Publication

	Authors: Tarver, C.L., Yuan, Q., Singhal, A.J., Ramaker, R., Cooper, S., Ng, J., Pusey, M.L.		Authors: Tarver, C.L., Yuan, Q., Singhal, A.J., Ramaker, R., Cooper, S., Ng, J., Pusey, M.L.
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	Description: Human Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) with Palmitic Acid		Description: Human Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) with Palmitic Acid
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Ramaker, R]]
		+	[[Category: Tarver, C.L]]
	[[Category: Cooper, S]]		[[Category: Cooper, S]]
	[[Category: Ng, J]]		[[Category: Ng, J]]
	[[Category: Pusey, M.L]]		[[Category: Pusey, M.L]]
	[[Category: Singhal, A.J]]		[[Category: Singhal, A.J]]
-	[[Category: Ramaker, R]]
	[[Category: Yuan, Q]]		[[Category: Yuan, Q]]
-	[[Category: Tarver, C.L]]

OCA: Protected "6u1u" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 14:01:42 GMT

Protected "6u1u" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:01, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6u1u is ON HOLD Authors: Tarver, C.L., Yuan, Q., Singhal, A.J., Ramaker, R., Cooper, S., Ng, J., Pusey, M.L. Description: Human Angiopoietin-Like 4...

OCA — Wed, 28 Aug 2019 14:01:41 GMT

New page: '''Unreleased structure''' The entry 6u1u is ON HOLD Authors: Tarver, C.L., Yuan, Q., Singhal, A.J., Ramaker, R., Cooper, S., Ng, J., Pusey, M.L. Description: Human Angiopoietin-Like 4...

New page

'''Unreleased structure'''

The entry 6u1u is ON HOLD

Authors: Tarver, C.L., Yuan, Q., Singhal, A.J., Ramaker, R., Cooper, S., Ng, J., Pusey, M.L.

Description: Human Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) with Palmitic Acid
[[Category: Unreleased Structures]]
[[Category: Cooper, S]]
[[Category: Ng, J]]
[[Category: Pusey, M.L]]
[[Category: Singhal, A.J]]
[[Category: Ramaker, R]]
[[Category: Yuan, Q]]
[[Category: Tarver, C.L]]