6u1y - Revision history

OCA at 14:56, 13 March 2024

OCA — Wed, 13 Mar 2024 14:56:21 GMT

←Older revision		Revision as of 14:56, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6u1y' size='340' side='right'caption='[[6u1y]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='6u1y' size='340' side='right'caption='[[6u1y]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u1y]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U1Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u1y]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~ADENYLATE+ESTER'>ANP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.17Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Bcs1l ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1y OCA], [~~http~~://pdbe.org/6u1y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u1y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u1y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1y OCA], [https://pdbe.org/6u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1y RCSB], [https://www.ebi.ac.uk/pdbsum/6u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BCS1_MOUSE BCS1_MOUSE]] Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).	+	[https://www.uniprot.org/uniprot/BCS1_MOUSE BCS1_MOUSE] Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The mitochondrial membrane-bound AAA protein Bcs1 translocate substrates across the mitochondrial inner membrane without previous unfolding. One substrate of Bcs1 is the iron-sulfur protein (ISP), a subunit of the respiratory Complex III. How Bcs1 translocates ISP across the membrane is unknown. Here we report structures of mouse Bcs1 in two different conformations, representing three nucleotide states. The apo and ADP-bound structures reveal a homo-heptamer and show a large putative substrate-binding cavity accessible to the matrix space. ATP binding drives a contraction of the cavity by concerted motion of the ATPase domains, which could push substrate across the membrane. Our findings shed light on the potential mechanism of translocating folded proteins across a membrane, offer insights into the assembly process of Complex III and allow mapping of human disease-associated mutations onto the Bcs1 structure.	+
-		+
-	Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.,Tang WK, Borgnia MJ, Hsu AL, Esser L, Fox T, de Val N, Xia D Nat Struct Mol Biol. 2020 Feb;27(2):202-209. doi: 10.1038/s41594-020-0373-0. Epub, 2020 Feb 10. PMID:32042153<ref>PMID:32042153</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6u1y" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Tang~~, W K~~]]	+	[[Category: Tang WK]]
-	[[Category: Xia, D]]	+	[[Category: Xia D]]
-	~~[[Category: Aaa atpase]]~~	+
-	~~[[Category: Bcs1]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:32, 26 February 2020

OCA — Wed, 26 Feb 2020 10:32:50 GMT

←Older revision		Revision as of 10:32, 26 February 2020
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BCS1_MOUSE BCS1_MOUSE]] Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).		[[http://www.uniprot.org/uniprot/BCS1_MOUSE BCS1_MOUSE]] Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mitochondrial membrane-bound AAA protein Bcs1 translocate substrates across the mitochondrial inner membrane without previous unfolding. One substrate of Bcs1 is the iron-sulfur protein (ISP), a subunit of the respiratory Complex III. How Bcs1 translocates ISP across the membrane is unknown. Here we report structures of mouse Bcs1 in two different conformations, representing three nucleotide states. The apo and ADP-bound structures reveal a homo-heptamer and show a large putative substrate-binding cavity accessible to the matrix space. ATP binding drives a contraction of the cavity by concerted motion of the ATPase domains, which could push substrate across the membrane. Our findings shed light on the potential mechanism of translocating folded proteins across a membrane, offer insights into the assembly process of Complex III and allow mapping of human disease-associated mutations onto the Bcs1 structure.
		+
		+	Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.,Tang WK, Borgnia MJ, Hsu AL, Esser L, Fox T, de Val N, Xia D Nat Struct Mol Biol. 2020 Feb;27(2):202-209. doi: 10.1038/s41594-020-0373-0. Epub, 2020 Feb 10. PMID:32042153<ref>PMID:32042153</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6u1y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:45, 13 February 2020

OCA — Thu, 13 Feb 2020 04:45:34 GMT

←Older revision		Revision as of 04:45, 13 February 2020
Line 3:		Line 3:
	<StructureSection load='6u1y' size='340' side='right'caption='[[6u1y]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='6u1y' size='340' side='right'caption='[[6u1y]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u1y]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u1y]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bcs1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1y OCA], [http://pdbe.org/6u1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1y RCSB], [http://www.ebi.ac.uk/pdbsum/6u1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1y OCA], [http://pdbe.org/6u1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1y RCSB], [http://www.ebi.ac.uk/pdbsum/6u1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1y ProSAT]</span></td></tr>
	</table>		</table>
Line 12:		Line 13:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Tang, W K]]		[[Category: Tang, W K]]
	[[Category: Xia, D]]		[[Category: Xia, D]]

OCA at 08:11, 5 February 2020

OCA — Wed, 05 Feb 2020 08:11:37 GMT

←Older revision		Revision as of 08:11, 5 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6u1y is ~~ON HOLD until 00 0001~~	+	==bcs1 AAA domain==
-		+	<StructureSection load='6u1y' size='340' side='right'caption='[[6u1y]], [[Resolution\|resolution]] 2.17Å' scene=''>
-	~~Authors~~: ~~Tang~~, W.K., ~~Xia~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6u1y]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U1Y FirstGlance]. <br>
-	~~Description~~: ~~bcs1 AAA domain~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1y OCA], [http://pdbe.org/6u1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u1y RCSB], [http://www.ebi.ac.uk/pdbsum/6u1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1y ProSAT]</span></td></tr>
-	[[Category: Tang, W.K]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BCS1_MOUSE BCS1_MOUSE]] Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tang, W K]]
	[[Category: Xia, D]]		[[Category: Xia, D]]
		+	[[Category: Aaa atpase]]
		+	[[Category: Bcs1]]
		+	[[Category: Hydrolase]]

OCA at 13:41, 11 December 2019

OCA — Wed, 11 Dec 2019 13:41:06 GMT

←Older revision		Revision as of 13:41, 11 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u1y is ON HOLD until ~~Paper Publication~~	+	The entry 6u1y is ON HOLD until 00 0001

-	Authors:	+	Authors: Tang, W.K., Xia, D.

-	Description:	+	Description: bcs1 AAA domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Tang, W.K]]
		+	[[Category: Xia, D]]

OCA at 08:06, 2 October 2019

OCA — Wed, 02 Oct 2019 08:06:59 GMT

←Older revision		Revision as of 08:06, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u1y is ON HOLD	+	The entry 6u1y is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6u1y" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 14:02:08 GMT

Protected "6u1y" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:02, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6u1y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Aug 2019 14:02:06 GMT

New page: '''Unreleased structure''' The entry 6u1y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u1y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]