6u3p - Revision history

OCA at 07:43, 11 October 2023

OCA — Wed, 11 Oct 2023 07:43:37 GMT

←Older revision		Revision as of 07:43, 11 October 2023
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	<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6U3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U3P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [https://pdbe.org/6u3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [https://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [~~http~~://pdbe.org/6u3p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>	+	[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6u3p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6u3p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acetylcholinesterase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gerlits, O]]	+	[[Category: Gerlits O]]
-	[[Category: Kovalevsky, A]]	+	[[Category: Kovalevsky A]]
-	[[Category: Radic, Z]]	+	[[Category: Radic Z]]
-	~~[[Category: Bis-oxime]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Reactivator complex~~]]	+

OCA at 07:27, 8 April 2020

OCA — Wed, 08 Apr 2020 07:27:11 GMT

←Older revision		Revision as of 07:27, 8 April 2020
Line 3:		Line 3:
	<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U3P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [http://pdbe.org/6u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [http://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [http://pdbe.org/6u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [http://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:39, 19 February 2020

OCA — Wed, 19 Feb 2020 07:39:50 GMT

←Older revision		Revision as of 07:39, 19 February 2020
Line 3:		Line 3:
	<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [http://pdbe.org/6u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [http://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [http://pdbe.org/6u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [http://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>		[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime-based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous system (CNS). Furthermore, it frequently binds to aromatic residues of OP-inhibited acetylcholinesterase (AChE) in orientations that are non-productive for AChE reactivation, and the structural diversity of OPs impedes efficient reactivation. Improvements of OP antidotes need to include much better access of AChE reactivators to the CNS and optimized orientation of the antidotes' nucleophile within the AChE active-center gorge. On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited human AChE (hAChE), here we created seven uncharged acetamido bis-oximes as candidate antidotes. Both oxime groups in these bis-oximes were attached to the same central, saturated heterocyclic core. Diverse protonation of the heterocyclic amines and oxime groups of the bis-oximes resulted in equilibration among up to 16 distinct ionization forms, including uncharged forms capable of diffusing into the CNS and multiple zwitterionic forms optimal for reactivation reactions. Conformationally diverse zwitterions that could act as structural antidote variants significantly improved in vitro reactivation of diverse OP-hAChE conjugates. Oxime group re-orientation of one of the bis-oximes, forcing it to point into the active center for reactivation, was confirmed by X-ray structural analysis. Our findings provide detailed structure-activity properties of several CNS-directed, uncharged aliphatic bis-oximes holding promise for use as protonation-dependent, conformationally adaptive, "smart" accelerated antidotes against OP toxicity.
		+
		+	Rational design, synthesis and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.,Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z J Biol Chem. 2020 Feb 4. pii: RA119.012400. doi: 10.1074/jbc.RA119.012400. PMID:32019865<ref>PMID:32019865</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6u3p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gerlits, O]]		[[Category: Gerlits, O]]

OCA at 04:28, 13 February 2020

OCA — Thu, 13 Feb 2020 04:28:28 GMT

←Older revision		Revision as of 04:28, 13 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6u3p is ~~ON HOLD until Paper Publication~~	+	==Binary complex of native hAChE with oxime reactivator LG-703==
-		+	<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~: ~~Kovalevsky~~, A., ~~Gerlits~~, O., ~~Radic~~, Z.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3P FirstGlance]. <br>
-	~~Description~~: ~~Binary complex~~ of ~~native hAChE with oxime reactivator LG-703~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [http://pdbe.org/6u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [http://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Gerlits, O]]		[[Category: Gerlits, O]]
		+	[[Category: Kovalevsky, A]]
	[[Category: Radic, Z]]		[[Category: Radic, Z]]
-	[[Category: ~~Kovalevsky, A~~]]	+	[[Category: Bis-oxime]]
		+	[[Category: Hydrolase]]
		+	[[Category: Reactivator complex]]

OCA at 08:09, 2 October 2019

OCA — Wed, 02 Oct 2019 08:09:30 GMT

←Older revision		Revision as of 08:09, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u3p is ON HOLD	+	The entry 6u3p is ON HOLD until Paper Publication

	Authors: Kovalevsky, A., Gerlits, O., Radic, Z.		Authors: Kovalevsky, A., Gerlits, O., Radic, Z.
Line 7:		Line 7:
	Description: Binary complex of native hAChE with oxime reactivator LG-703		Description: Binary complex of native hAChE with oxime reactivator LG-703
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Gerlits, O]]
	[[Category: Radic, Z]]		[[Category: Radic, Z]]
	[[Category: Kovalevsky, A]]		[[Category: Kovalevsky, A]]
-	[[Category: Gerlits, O]]

OCA: Protected "6u3p" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 14:07:03 GMT

Protected "6u3p" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:07, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6u3p is ON HOLD Authors: Kovalevsky, A., Gerlits, O., Radic, Z. Description: Binary complex of native hAChE with oxime reactivator LG-703 [[Categor...

OCA — Wed, 28 Aug 2019 14:07:01 GMT

New page: '''Unreleased structure''' The entry 6u3p is ON HOLD Authors: Kovalevsky, A., Gerlits, O., Radic, Z. Description: Binary complex of native hAChE with oxime reactivator LG-703 [[Categor...

New page

'''Unreleased structure'''

The entry 6u3p is ON HOLD

Authors: Kovalevsky, A., Gerlits, O., Radic, Z.

Description: Binary complex of native hAChE with oxime reactivator LG-703
[[Category: Unreleased Structures]]
[[Category: Radic, Z]]
[[Category: Kovalevsky, A]]
[[Category: Gerlits, O]]