OCA at 11:26, 23 September 2020

OCA — Wed, 23 Sep 2020 11:26:13 GMT

←Older revision		Revision as of 11:26, 23 September 2020
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	==Human talin2 residues 1-403==		==Human talin2 residues 1-403==
-	<StructureSection load='6u4k' size='340' side='right'caption='[[6u4k]]' scene=''>	+	<StructureSection load='6u4k' size='340' side='right'caption='[[6u4k]], [[Resolution\|resolution]] 2.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U4K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U4K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U4K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U4K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u4k OCA], [http://pdbe.org/6u4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u4k RCSB], [http://www.ebi.ac.uk/pdbsum/6u4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u4k ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLN2, KIAA0320 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u4k OCA], [http://pdbe.org/6u4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u4k RCSB], [http://www.ebi.ac.uk/pdbsum/6u4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u4k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TLN2_HUMAN TLN2_HUMAN]] As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Integrin receptors regulate normal cellular processes such as signaling, cell migration, adhesion to the extracellular matrix, and leukocyte function. Talin recruitment to the membrane is necessary for its binding to and activation of integrin. Vertebrates have two highly conserved talin homologs that differ in their expression patterns. The F1-F3 FERM subdomains of cytoskeletal proteins resemble a cloverleaf, but in talin1, its F1 subdomain and additional F0 subdomain align more linearly with its F2 and F3 subdomains. Here, we present the talin2 crystal structure, revealing that its F0-F1 di-subdomain displays another unprecedented constellation, whereby the F0-F1-F2 adopts a new cloverleaf-like arrangement. Using multiangle light scattering (MALS), fluorescence lifetime imaging (FLIM), and FRET analyses, we found that substituting the corresponding residues in talin2 that abolish lipid binding in talin1 disrupt the binding of talin to the membrane, focal adhesion formation, and cell spreading. Our results provide the molecular details of the functions of specific talin isoforms in cell adhesion.
		+
		+	A distinct talin2 structure directs isoform specificity in cell adhesion.,Rangarajan ES, Primi MC, Colgan LA, Chinthalapudi K, Yasuda R, Izard T J Biol Chem. 2020 Sep 11;295(37):12885-12899. doi: 10.1074/jbc.RA119.010789. Epub, 2020 Jun 30. PMID:32605925<ref>PMID:32605925</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6u4k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chinthalapudi K]]	+	[[Category: Chinthalapudi, K]]
-	[[Category: Colgan L]]	+	[[Category: Colgan, L]]
-	[[Category: Izard T]]	+	[[Category: Izard, T]]
-	[[Category: Rangarajan ES]]	+	[[Category: Rangarajan, E S]]
-	[[Category: Yasuda R]]	+	[[Category: Yasuda, R]]
		+	[[Category: Actin]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Integrin]]
		+	[[Category: Lipid-binding protein]]
		+	[[Category: Talin]]
		+	[[Category: Tumor suppressor gene]]
		+	[[Category: Vinculin]]

OCA at 14:06, 8 July 2020

OCA — Wed, 08 Jul 2020 14:06:39 GMT

←Older revision		Revision as of 14:06, 8 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6u4k is ~~ON HOLD until Paper Publication~~	+	==Human talin2 residues 1-403==
-		+	<StructureSection load='6u4k' size='340' side='right'caption='[[6u4k]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U4K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U4K FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u4k OCA], [http://pdbe.org/6u4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u4k RCSB], [http://www.ebi.ac.uk/pdbsum/6u4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u4k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chinthalapudi K]]
		+	[[Category: Colgan L]]
		+	[[Category: Izard T]]
		+	[[Category: Rangarajan ES]]
		+	[[Category: Yasuda R]]

OCA at 03:52, 10 October 2019

OCA — Thu, 10 Oct 2019 03:52:43 GMT

←Older revision		Revision as of 03:52, 10 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u4k is ON HOLD	+	The entry 6u4k is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6u4k" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 08:11:50 GMT

Protected "6u4k" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:11, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6u4k is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 08:11:48 GMT

New page: '''Unreleased structure''' The entry 6u4k is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u4k is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6u4k - Revision history

OCA at 11:26, 23 September 2020

OCA at 14:06, 8 July 2020

OCA at 03:52, 10 October 2019

OCA: Protected "6u4k" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6u4k is ON HOLD Authors: Description: Category: Unreleased Structures