6u5s - Revision history

OCA at 06:40, 11 April 2020

OCA — Sat, 11 Apr 2020 06:40:03 GMT

←Older revision		Revision as of 06:40, 11 April 2020
Line 3:		Line 3:
	<SX load='6u5s' size='340' side='right' viewer='molstar' caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>		<SX load='6u5s' size='340' side='right' viewer='molstar' caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U5S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5s OCA], [http://pdbe.org/6u5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5s RCSB], [http://www.ebi.ac.uk/pdbsum/6u5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5s OCA], [http://pdbe.org/6u5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5s RCSB], [http://www.ebi.ac.uk/pdbsum/6u5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:07, 7 March 2020

OCA — Sat, 07 Mar 2020 01:07:14 GMT

←Older revision		Revision as of 01:07, 7 March 2020
Line 1:		Line 1:

	==NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation==		==NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation==
-	<~~StructureSection~~ load='6u5s' size='340' side='right'caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>	+	<SX load='6u5s' size='340' side='right' viewer='molstar' caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5S FirstGlance]. <br>		<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5S FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 13:17, 18 December 2019

OCA — Wed, 18 Dec 2019 13:17:49 GMT

←Older revision		Revision as of 13:17, 18 December 2019
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>		[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the brain, AMPA-type glutamate receptors (AMPARs) form complexes with their auxiliary subunits and mediate the majority of fast excitatory neurotransmission. Signals transduced by these complexes are critical for synaptic plasticity, learning, and memory. The two major categories of AMPAR auxiliary subunits are transmembrane AMPAR regulatory proteins (TARPs) and cornichon homologs (CNIHs); these subunits share little homology and play distinct roles in controlling ion channel gating and trafficking of AMPAR. Here, I report high-resolution cryo-electron microscopy structures of AMPAR in complex with CNIH3. Contrary to its predicted membrane topology, CNIH3 lacks an extracellular domain and instead contains four membrane-spanning helices. The protein-protein interaction interface that dictates channel modulation and the lipids surrounding the complex are revealed. These structures provide insights into the molecular mechanism for ion channel modulation and assembly of AMPAR/CNIH3 complexes.
		+
		+	Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.,Nakagawa T Science. 2019 Dec 6;366(6470):1259-1263. doi: 10.1126/science.aay2783. PMID:31806817<ref>PMID:31806817</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6u5s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:49, 11 December 2019

OCA — Wed, 11 Dec 2019 18:49:47 GMT

←Older revision		Revision as of 18:49, 11 December 2019
Line 3:		Line 3:
	<StructureSection load='6u5s' size='340' side='right'caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>		<StructureSection load='6u5s' size='340' side='right'caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5s OCA], [http://pdbe.org/6u5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5s RCSB], [http://www.ebi.ac.uk/pdbsum/6u5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5s OCA], [http://pdbe.org/6u5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5s RCSB], [http://www.ebi.ac.uk/pdbsum/6u5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5s ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Nakagawa, T]]		[[Category: Nakagawa, T]]

OCA at 08:20, 4 December 2019

OCA — Wed, 04 Dec 2019 08:20:05 GMT

←Older revision		Revision as of 08:20, 4 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6u5s is ~~ON HOLD until Paper Publication~~	+	==NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation==
-		+	<StructureSection load='6u5s' size='340' side='right'caption='[[6u5s]], [[Resolution\|resolution]] 3.07Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6u5s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5S FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5s OCA], [http://pdbe.org/6u5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5s RCSB], [http://www.ebi.ac.uk/pdbsum/6u5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5s ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Nakagawa, T]]
		+	[[Category: Ampa receptor]]
		+	[[Category: Auxiliary subunit]]
		+	[[Category: Cornichon]]
		+	[[Category: Excitatory synaptic transmission]]
		+	[[Category: Ion channel]]
		+	[[Category: Ionotropic glutamate receptor]]
		+	[[Category: Ligand gated ion channel]]
		+	[[Category: Lipid]]
		+	[[Category: Mpqx]]
		+	[[Category: Neurotransmitter receptor]]
		+	[[Category: Stargazin]]
		+	[[Category: Synaptic transmission]]
		+	[[Category: Tarp]]
		+	[[Category: Transport protein]]
		+	[[Category: Zk200775]]

OCA at 05:20, 27 November 2019

OCA — Wed, 27 Nov 2019 05:20:01 GMT

←Older revision		Revision as of 05:20, 27 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6u5s is ON HOLD	+	The entry 6u5s is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6u5s" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 08:15:31 GMT

Protected "6u5s" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:15, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6u5s is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 08:15:29 GMT

New page: '''Unreleased structure''' The entry 6u5s is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u5s is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]