OCA at 07:46, 11 October 2023

OCA — Wed, 11 Oct 2023 07:46:37 GMT

←Older revision		Revision as of 07:46, 11 October 2023
Line 1:		Line 1:

	==Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA==		==Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA==
-	<StructureSection load='6u90' size='340' side='right'caption='[[6u90]]' scene=''>	+	<StructureSection load='6u90' size='340' side='right'caption='[[6u90]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U90 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6U90 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U90 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u90 OCA], [~~http~~://pdbe.org/6u90 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u90 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u90 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u90 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.0008175Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PYO:1-(BETA-D-RIBOFURANOSYL)-PYRIMIDIN-2-ONE-5-PHOSPHATE'>PYO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u90 OCA], [https://pdbe.org/6u90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u90 RCSB], [https://www.ebi.ac.uk/pdbsum/6u90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u90 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
		+
		+	==See Also==
		+	*[[DNA methyltransferase 3D structures\|DNA methyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gao L]]		[[Category: Gao L]]
	[[Category: Song J]]		[[Category: Song J]]

OCA at 06:27, 10 June 2020

OCA — Wed, 10 Jun 2020 06:27:14 GMT

←Older revision		Revision as of 06:27, 10 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6u90 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA==
-		+	<StructureSection load='6u90' size='340' side='right'caption='[[6u90]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U90 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U90 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u90 OCA], [http://pdbe.org/6u90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u90 RCSB], [http://www.ebi.ac.uk/pdbsum/6u90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u90 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gao L]]
		+	[[Category: Song J]]

OCA: Protected "6u90" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 08:24:52 GMT

Protected "6u90" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:24, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6u90 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 08:24:50 GMT

New page: '''Unreleased structure''' The entry 6u90 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u90 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6u90 - Revision history

OCA at 07:46, 11 October 2023

OCA at 06:27, 10 June 2020

OCA: Protected "6u90" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6u90 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures