6uen - Revision history

OCA at 09:29, 20 March 2024

OCA — Wed, 20 Mar 2024 09:29:26 GMT

←Older revision		Revision as of 09:29, 20 March 2024
Line 3:		Line 3:
	<SX load='6uen' size='340' side='right' viewer='molstar' caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>		<SX load='6uen' size='340' side='right' viewer='molstar' caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hrsv Hrsv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6UEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">L, ~~MZ07_64039gpL, MZ07_64040gpL (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=11250 HRSV])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.67Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [~~http~~://pdbe.org/6uen PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6uen PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [https://pdbe.org/6uen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [https://www.ebi.ac.uk/pdbsum/6uen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~G8EJ12_HRSV G8EJ12_HRSV~~]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as ~~transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by~~ a ~~stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode,~~ the ~~polymerase replicates the whole viral genome without recognizing the transcriptional signals.[PIRNR:PIRNR000830]~~	+	[https://www.uniprot.org/uniprot/PHOSP_HRSVA PHOSP_HRSVA] Acts as a cofactor that serves both to stabilize the protein L and to place the polymerase complex on the N:RNA template.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L)~~ protein ~~and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities - nucleotide polymerization, cap addition, and cap methylation. How RSV~~ L and ~~P coordinate these activities is poorly understood. Here, we present a 3.67 A cryo-EM structure of~~ the ~~RSV~~ polymerase ~~(L:P)~~ complex. The structure reveals that the RNA dependent RNA polymerase (RdRp) and capping (Cap) domains of L interact with the oligomerization domain (POD) and C-terminal domain (PCTD) of a tetramer of P. The density of the methyltransferase (MT) domain of L and the N~~-terminal domain of P (PNTD) is missing. Further analysis and comparison with other~~ RNA polymerases at different stages suggest the structure we obtained is likely to be at an elongation-compatible stage. Together, these data provide enriched insights into the interrelationship, the inhibitors, and the evolutionary implications of the RSV polymerase.	+

-	Cryo-EM structure of the respiratory syncytial virus RNA polymerase.,Cao D, Gao Y, Roesler C, Rice S, D'Cunha P, Zhuang L, Slack J, Domke M, Antonova A, Romanelli S, Keating S, Forero G, Juneja P, Liang B Nat Commun. 2020 Jan 17;11(1):368. doi: 10.1038/s41467-019-14246-3. PMID:31953395<ref>PMID:31953395</ref>	+	==See Also==
-		+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6uen" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Hrsv~~]]	+	[[Category: Human orthopneumovirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cao, D]]	+	[[Category: Cao D]]
-	[[Category: Gao, Y]]	+	[[Category: Gao Y]]
-	[[Category: Liang, B]]	+	[[Category: Liang B]]
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Viral protein complex]]~~	+
-	~~[[Category: Viral protein-transferase complex~~]]	+

OCA at 06:47, 11 April 2020

OCA — Sat, 11 Apr 2020 06:47:06 GMT

←Older revision		Revision as of 06:47, 11 April 2020
Line 3:		Line 3:
	<SX load='6uen' size='340' side='right' viewer='molstar' caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>		<SX load='6uen' size='340' side='right' viewer='molstar' caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6UEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L, MZ07_64039gpL, MZ07_64040gpL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11250 HRSV])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L, MZ07_64039gpL, MZ07_64040gpL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11250 HRSV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:09, 7 March 2020

OCA — Sat, 07 Mar 2020 01:09:59 GMT

←Older revision		Revision as of 01:09, 7 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the respiratory syncytial virus RNA polymerase==		==Cryo-EM structure of the respiratory syncytial virus RNA polymerase==
-	<~~StructureSection~~ load='6uen' size='340' side='right'caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>	+	<SX load='6uen' size='340' side='right' viewer='molstar' caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br>		<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Hrsv]]		[[Category: Hrsv]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:26, 29 January 2020

OCA — Wed, 29 Jan 2020 16:26:15 GMT

←Older revision		Revision as of 16:26, 29 January 2020
Line 3:		Line 3:
	<StructureSection load='6uen' size='340' side='right'caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>		<StructureSection load='6uen' size='340' side='right'caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L, MZ07_64039gpL, MZ07_64040gpL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11250 HRSV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/G8EJ12_HRSV G8EJ12_HRSV]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.[PIRNR:PIRNR000830]		[[http://www.uniprot.org/uniprot/G8EJ12_HRSV G8EJ12_HRSV]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.[PIRNR:PIRNR000830]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L) protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities - nucleotide polymerization, cap addition, and cap methylation. How RSV L and P coordinate these activities is poorly understood. Here, we present a 3.67 A cryo-EM structure of the RSV polymerase (L:P) complex. The structure reveals that the RNA dependent RNA polymerase (RdRp) and capping (Cap) domains of L interact with the oligomerization domain (POD) and C-terminal domain (PCTD) of a tetramer of P. The density of the methyltransferase (MT) domain of L and the N-terminal domain of P (PNTD) is missing. Further analysis and comparison with other RNA polymerases at different stages suggest the structure we obtained is likely to be at an elongation-compatible stage. Together, these data provide enriched insights into the interrelationship, the inhibitors, and the evolutionary implications of the RSV polymerase.
		+
		+	Cryo-EM structure of the respiratory syncytial virus RNA polymerase.,Cao D, Gao Y, Roesler C, Rice S, D'Cunha P, Zhuang L, Slack J, Domke M, Antonova A, Romanelli S, Keating S, Forero G, Juneja P, Liang B Nat Commun. 2020 Jan 17;11(1):368. doi: 10.1038/s41467-019-14246-3. PMID:31953395<ref>PMID:31953395</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6uen" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hrsv]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cao, D]]		[[Category: Cao, D]]

OCA at 16:22, 22 January 2020

OCA — Wed, 22 Jan 2020 16:22:31 GMT

←Older revision		Revision as of 16:22, 22 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6uen ~~is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of the respiratory syncytial virus RNA polymerase==
-		+	<StructureSection load='6uen' size='340' side='right'caption='[[6uen]], [[Resolution\|resolution]] 3.67Å' scene=''>
-	~~Authors~~: ~~Cao~~, D., ~~Gao~~, Y., ~~Liang~~, B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of the ~~respiratory syncytial virus~~ RNA polymerase	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G8EJ12_HRSV G8EJ12_HRSV]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.[PIRNR:PIRNR000830]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cao, D]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]
-	[[Category: Cao, D]]
	[[Category: Liang, B]]		[[Category: Liang, B]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein complex]]
		+	[[Category: Viral protein-transferase complex]]

OCA at 06:46, 1 January 2020

OCA — Wed, 01 Jan 2020 06:46:36 GMT

←Older revision		Revision as of 06:46, 1 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6uen is ON HOLD	+	The entry 6uen is ON HOLD until Paper Publication

	Authors: Cao, D., Gao, Y., Liang, B.		Authors: Cao, D., Gao, Y., Liang, B.

OCA at 07:28, 25 December 2019

OCA — Wed, 25 Dec 2019 07:28:38 GMT

←Older revision		Revision as of 07:28, 25 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6uen is ON HOLD ~~until Paper Publication~~	+	The entry 6uen is ON HOLD

	Authors: Cao, D., Gao, Y., Liang, B.		Authors: Cao, D., Gao, Y., Liang, B.

-	Description: ~~Conformational transitions~~ of the respiratory syncytial virus RNA polymerase	+	Description: Cryo-EM structure of the respiratory syncytial virus RNA polymerase
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]
	[[Category: Cao, D]]		[[Category: Cao, D]]
	[[Category: Liang, B]]		[[Category: Liang, B]]

OCA at 13:48, 20 November 2019

OCA — Wed, 20 Nov 2019 13:48:09 GMT

←Older revision		Revision as of 13:48, 20 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6uen is ON HOLD	+	The entry 6uen is ON HOLD until Paper Publication

	Authors: Cao, D., Gao, Y., Liang, B.		Authors: Cao, D., Gao, Y., Liang, B.

OCA: Protected "6uen" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 08:42:41 GMT

Protected "6uen" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:42, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6uen is ON HOLD Authors: Cao, D., Gao, Y., Liang, B. Description: Conformational transitions of the respiratory syncytial virus RNA polymerase [[Ca...

OCA — Wed, 02 Oct 2019 08:42:40 GMT

New page: '''Unreleased structure''' The entry 6uen is ON HOLD Authors: Cao, D., Gao, Y., Liang, B. Description: Conformational transitions of the respiratory syncytial virus RNA polymerase [[Ca...

New page

'''Unreleased structure'''

The entry 6uen is ON HOLD

Authors: Cao, D., Gao, Y., Liang, B.

Description: Conformational transitions of the respiratory syncytial virus RNA polymerase
[[Category: Unreleased Structures]]
[[Category: Gao, Y]]
[[Category: Cao, D]]
[[Category: Liang, B]]