6uhs - Revision history

OCA at 07:51, 11 October 2023

OCA — Wed, 11 Oct 2023 07:51:38 GMT

←Older revision		Revision as of 07:51, 11 October 2023
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	==Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human==		==Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human==
-	<StructureSection load='6uhs' size='340' side='right'caption='[[6uhs]]' scene=''>	+	<StructureSection load='6uhs' size='340' side='right'caption='[[6uhs]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UHS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6UHS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6uhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UHS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uhs OCA], [~~http~~://pdbe.org/6uhs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6uhs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6uhs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6uhs ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.46Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uhs OCA], [https://pdbe.org/6uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uhs RCSB], [https://www.ebi.ac.uk/pdbsum/6uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uhs ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/RYR1_HUMAN RYR1_HUMAN] Congenital myopathy with myasthenic-like onset;Moderate multiminicore disease with hand involvement;Congenital multicore myopathy with external ophthalmoplegia;King-Denborough syndrome;Lethal multiple pterygium syndrome;Benign Samaritan congenital myopathy;Malignant hyperthermia of anesthesia;Autosomal recessive centronuclear myopathy;Autosomal dominant centronuclear myopathy;Exercise-induced malignant hyperthermia;Central core disease. Disease susceptibility is associated with variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course. Patients display severe hypotonia and respiratory distress at birth. Unlike other congenital myopathies, the health status constantly improves and patients are minimally affected at adulthood. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RYR1_HUMAN RYR1_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).[UniProtKB:E9PZQ0]<ref>PMID:18268335</ref> <ref>PMID:11741831</ref> <ref>PMID:16163667</ref> [https://www.uniprot.org/uniprot/Q8A5J2_BACTN Q8A5J2_BACTN]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacteroides thetaiotaomicron VPI-5482]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Jedrzejczak R]]		[[Category: Jedrzejczak R]]
	[[Category: Joachimiak A]]		[[Category: Joachimiak A]]
	[[Category: Wu R]]		[[Category: Wu R]]

OCA at 09:47, 16 September 2020

OCA — Wed, 16 Sep 2020 09:47:40 GMT

←Older revision		Revision as of 09:47, 16 September 2020
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-	'''Unreleased structure'''

-	~~The entry 6uhs is ON HOLD~~	+	==Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human==
-		+	<StructureSection load='6uhs' size='340' side='right'caption='[[6uhs]]' scene=''>
-	~~Authors: Wu, R., Jedrzejczak, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UHS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UHS FirstGlance]. <br>
-	~~Description:~~ Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uhs OCA], [http://pdbe.org/6uhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uhs RCSB], [http://www.ebi.ac.uk/pdbsum/6uhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uhs ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: Wu, R]]	+	__TOC__
-	[[Category: ~~Joachimiak, A~~]]	+	</StructureSection>
-	[[Category: ~~Midwest Center For Structural Genomics (Mcsg)~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Jedrzejczak,~~ R]]	+	[[Category: Jedrzejczak R]]
		+	[[Category: Joachimiak A]]
		+	[[Category: Wu R]]

OCA: Protected "6uhs" [edit=sysop:move=sysop]

OCA — Thu, 10 Oct 2019 03:57:59 GMT

Protected "6uhs" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:57, 10 October 2019

OCA: New page: '''Unreleased structure''' The entry 6uhs is ON HOLD Authors: Wu, R., Jedrzejczak, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG) Description: Open-form Crystal Stru...

OCA — Thu, 10 Oct 2019 03:57:57 GMT

New page: '''Unreleased structure''' The entry 6uhs is ON HOLD Authors: Wu, R., Jedrzejczak, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG) Description: Open-form Crystal Stru...

New page

'''Unreleased structure'''

The entry 6uhs is ON HOLD

Authors: Wu, R., Jedrzejczak, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)

Description: Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human
[[Category: Unreleased Structures]]
[[Category: Wu, R]]
[[Category: Joachimiak, A]]
[[Category: Midwest Center For Structural Genomics (Mcsg)]]
[[Category: Jedrzejczak, R]]