6ule - Revision history

OCA at 07:53, 11 October 2023

OCA — Wed, 11 Oct 2023 07:53:48 GMT

←Older revision		Revision as of 07:53, 11 October 2023
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	<StructureSection load='6ule' size='340' side='right'caption='[[6ule]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='6ule' size='340' side='right'caption='[[6ule]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ule]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ULE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ule]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ULE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ule FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ule OCA], [~~http~~://pdbe.org/6ule PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ule RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ule PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ule ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ule FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ule OCA], [https://pdbe.org/6ule PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ule RCSB], [https://www.ebi.ac.uk/pdbsum/6ule PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ule ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CSP_PLAFA CSP_PLAFA]~~] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).	+	[https://www.uniprot.org/uniprot/CSP_PLAFO CSP_PLAFO] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6ule" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ule" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Julien~~, J P~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Murugan, R]]	+	[[Category: Julien JP]]
-	[[Category: Scally~~, S W~~]]	+	[[Category: Murugan R]]
-	[[Category: Thai, E]]	+	[[Category: Scally SW]]
-	[[Category: Wardemann, H]]	+	[[Category: Thai E]]
-	~~[[Category: Antibody]]~~	+	[[Category: Wardemann H]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Malaria~~]]	+

OCA at 11:35, 29 July 2020

OCA — Wed, 29 Jul 2020 11:35:54 GMT

←Older revision		Revision as of 11:35, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of 2541 Fab in complex with circumsporozoite protein NANP5==		==Crystal structure of 2541 Fab in complex with circumsporozoite protein NANP5==
-	<StructureSection load='6ule' size='340' side='right'caption='[[6ule]]' scene=''>	+	<StructureSection load='6ule' size='340' side='right'caption='[[6ule]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ule]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ule FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ule OCA], [http://pdbe.org/6ule PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ule RCSB], [http://www.ebi.ac.uk/pdbsum/6ule PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ule ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ule FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ule OCA], [http://pdbe.org/6ule PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ule RCSB], [http://www.ebi.ac.uk/pdbsum/6ule PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ule ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSP_PLAFA CSP_PLAFA]] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in animal models. However, the limited efficacy of the PfCSP-based vaccine RTS,S calls for a better understanding of the mechanisms driving the development of the most potent human PfCSP antibodies and identification of their target epitopes. By characterizing 200 human monoclonal PfCSP antibodies induced by sporozoite immunization, we establish that the most potent antibodies bind around a conserved (N/D)PNANPN(V/A) core. High antibody affinity to the core correlates with protection from parasitemia in mice and evolves around the recognition of NANP motifs. The data suggest that the rational design of a next-generation PfCSP vaccine that elicits high-affinity antibody responses against the core epitope will promote the induction of protective humoral immune responses.
		+
		+	Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.,Murugan R, Scally SW, Costa G, Mustafa G, Thai E, Decker T, Bosch A, Prieto K, Levashina EA, Julien JP, Wardemann H Nat Med. 2020 May 25. pii: 10.1038/s41591-020-0881-9. doi:, 10.1038/s41591-020-0881-9. PMID:32451496<ref>PMID:32451496</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ule" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Julien JP]]	+	[[Category: Julien, J P]]
-	[[Category: Murugan R]]	+	[[Category: Murugan, R]]
-	[[Category: Scally SW]]	+	[[Category: Scally, S W]]
-	[[Category: Thai E]]	+	[[Category: Thai, E]]
-	[[Category: Wardemann H]]	+	[[Category: Wardemann, H]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Malaria]]

OCA at 06:27, 10 June 2020

OCA — Wed, 10 Jun 2020 06:27:20 GMT

←Older revision		Revision as of 06:27, 10 June 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ule is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of 2541 Fab in complex with circumsporozoite protein NANP5==
-		+	<StructureSection load='6ule' size='340' side='right'caption='[[6ule]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ule FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ule OCA], [http://pdbe.org/6ule PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ule RCSB], [http://www.ebi.ac.uk/pdbsum/6ule PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ule ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Julien JP]]
		+	[[Category: Murugan R]]
		+	[[Category: Scally SW]]
		+	[[Category: Thai E]]
		+	[[Category: Wardemann H]]

OCA at 05:10, 23 October 2019

OCA — Wed, 23 Oct 2019 05:10:20 GMT

←Older revision		Revision as of 05:10, 23 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ule is ON HOLD	+	The entry 6ule is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ule" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:38:30 GMT

Protected "6ule" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:38, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ule is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Oct 2019 04:38:28 GMT

New page: '''Unreleased structure''' The entry 6ule is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ule is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]