6ulf - Revision history

OCA at 07:53, 11 October 2023

OCA — Wed, 11 Oct 2023 07:53:49 GMT

←Older revision		Revision as of 07:53, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6ulf' size='340' side='right'caption='[[6ulf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6ulf' size='340' side='right'caption='[[6ulf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ulf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ULF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ulf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae_mixed_library Camelidae mixed library], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ULF FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=UNK:UNKNOWN'>UNK</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ulf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulf OCA], [~~http~~://pdbe.org/6ulf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ulf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ulf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ulf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulf OCA], [https://pdbe.org/6ulf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ulf RCSB], [https://www.ebi.ac.uk/pdbsum/6ulf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CSP_PLAFA CSP_PLAFA]~~] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).	+	[https://www.uniprot.org/uniprot/CSP_PLAFO CSP_PLAFO] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6ulf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ulf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Camelidae mixed library]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Julien~~, J P~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Murugan, R]]	+	[[Category: Julien JP]]
-	[[Category: Prieto, K]]	+	[[Category: Murugan R]]
-	[[Category: Scally~~, S W~~]]	+	[[Category: Prieto K]]
-	[[Category: Thai, E]]	+	[[Category: Scally SW]]
-	[[Category: Wardemann, H]]	+	[[Category: Thai E]]
-	~~[[Category: Antibody]]~~	+	[[Category: Wardemann H]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Malaria~~]]	+

OCA at 07:04, 25 June 2020

OCA — Thu, 25 Jun 2020 07:04:43 GMT

←Older revision		Revision as of 07:04, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of 4498 Fab in complex with circumsporozoite protein NDN3 and anti-Kappa VHH domain==		==Crystal structure of 4498 Fab in complex with circumsporozoite protein NDN3 and anti-Kappa VHH domain==
-	<StructureSection load='6ulf' size='340' side='right'caption='[[6ulf]]' scene=''>	+	<StructureSection load='6ulf' size='340' side='right'caption='[[6ulf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ulf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ulf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulf OCA], [http://pdbe.org/6ulf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulf RCSB], [http://www.ebi.ac.uk/pdbsum/6ulf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulf ProSAT]</span></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ulf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulf OCA], [http://pdbe.org/6ulf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulf RCSB], [http://www.ebi.ac.uk/pdbsum/6ulf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSP_PLAFA CSP_PLAFA]] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in animal models. However, the limited efficacy of the PfCSP-based vaccine RTS,S calls for a better understanding of the mechanisms driving the development of the most potent human PfCSP antibodies and identification of their target epitopes. By characterizing 200 human monoclonal PfCSP antibodies induced by sporozoite immunization, we establish that the most potent antibodies bind around a conserved (N/D)PNANPN(V/A) core. High antibody affinity to the core correlates with protection from parasitemia in mice and evolves around the recognition of NANP motifs. The data suggest that the rational design of a next-generation PfCSP vaccine that elicits high-affinity antibody responses against the core epitope will promote the induction of protective humoral immune responses.
		+
		+	Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.,Murugan R, Scally SW, Costa G, Mustafa G, Thai E, Decker T, Bosch A, Prieto K, Levashina EA, Julien JP, Wardemann H Nat Med. 2020 May 25. pii: 10.1038/s41591-020-0881-9. doi:, 10.1038/s41591-020-0881-9. PMID:32451496<ref>PMID:32451496</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ulf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Julien JP]]	+	[[Category: Julien, J P]]
-	[[Category: Murugan R]]	+	[[Category: Murugan, R]]
-	[[Category: Prieto K]]	+	[[Category: Prieto, K]]
-	[[Category: Scally SW]]	+	[[Category: Scally, S W]]
-	[[Category: Thai E]]	+	[[Category: Thai, E]]
-	[[Category: Wardemann H]]	+	[[Category: Wardemann, H]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Malaria]]

OCA at 10:12, 17 June 2020

OCA — Wed, 17 Jun 2020 10:12:24 GMT

←Older revision		Revision as of 10:12, 17 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ulf is ~~ON HOLD until sometime in~~ the ~~future~~	+	==Crystal structure of 4498 Fab in complex with circumsporozoite protein NDN3 and anti-Kappa VHH domain==
-		+	<StructureSection load='6ulf' size='340' side='right'caption='[[6ulf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ulf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulf OCA], [http://pdbe.org/6ulf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulf RCSB], [http://www.ebi.ac.uk/pdbsum/6ulf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Julien JP]]
		+	[[Category: Murugan R]]
		+	[[Category: Prieto K]]
		+	[[Category: Scally SW]]
		+	[[Category: Thai E]]
		+	[[Category: Wardemann H]]

OCA: Protected "6ulf" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:38:34 GMT

Protected "6ulf" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:38, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ulf is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Oct 2019 04:38:32 GMT

New page: '''Unreleased structure''' The entry 6ulf is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ulf is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]