6urh - Revision history

OCA at 07:56, 11 October 2023

OCA — Wed, 11 Oct 2023 07:56:58 GMT

←Older revision		Revision as of 07:56, 11 October 2023
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	<StructureSection load='6urh' size='340' side='right'caption='[[6urh]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6urh' size='340' side='right'caption='[[6urh]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6urh]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6URH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6urh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6URH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6urh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6urh OCA], [~~http~~://pdbe.org/6urh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6urh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6urh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6urh ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6urh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6urh OCA], [https://pdbe.org/6urh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6urh RCSB], [https://www.ebi.ac.uk/pdbsum/6urh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6urh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2P0NE26_9HEPC A0A2P0NE26_9HEPC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6urh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6urh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hepacivirus C]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bjorkman~~, P J~~]]	+	[[Category: Bjorkman PJ]]
-	[[Category: Flyak~~, A I]]~~	+	[[Category: Flyak AI]]
-	~~[[Category: Broadly neutralizing antibody]]~~	+
-	~~[[Category: Hcv glycoprotein]]~~	+
-	~~[[Category: Viral protein-immune system complex~~]]	+

OCA at 09:58, 18 March 2020

OCA — Wed, 18 Mar 2020 09:58:21 GMT

←Older revision		Revision as of 09:58, 18 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6urh is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain==
		+	<StructureSection load='6urh' size='340' side='right'caption='[[6urh]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6urh]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6URH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6urh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6urh OCA], [http://pdbe.org/6urh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6urh RCSB], [http://www.ebi.ac.uk/pdbsum/6urh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6urh ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structures of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infected individuals, revealed a disulfide bond-containing CDRH3 that adopts straight (individuals who clear infection) or bent (individuals with chronic infection) conformation. To investigate whether a straight versus bent disulfide bond-containing CDRH3 is specific to particular HCV-infected individuals, we solved a crystal structure of the HCV E2 ectodomain in complex with AR3X, a bNAb with an unusually long CDRH2 that was isolated from the chronically-infected individual from whom the bent CDRH3 bNAbs were derived. The structure revealed that AR3X utilizes both its ultralong CDRH2 and a disulfide motif-containing straight CDRH3 to recognize the E2 front layer. These results demonstrate that both the straight and bent CDRH3 classes of HCV bNAb can be elicited in a single individual, revealing a structural plasticity of VH1-69-derived bNAbs.

-	~~Authors:~~ Flyak, ~~A.I.~~, ~~Bjorkman~~, P.J.	+	An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein.,Flyak AI, Ruiz SE, Salas J, Rho S, Bailey JR, Bjorkman PJ Elife. 2020 Mar 3;9. pii: 53169. doi: 10.7554/eLife.53169. PMID:32125272<ref>PMID:32125272</ref>

-	~~Description: Crystal structure~~ of ~~broadly neutralizing antibody AR3X in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Bjorkman, P.J]]	+	<div class="pdbe-citations 6urh" style="background-color:#fffaf0;"></div>
-	[[Category: Flyak, A.I]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bjorkman, P J]]
		+	[[Category: Flyak, A I]]
		+	[[Category: Broadly neutralizing antibody]]
		+	[[Category: Hcv glycoprotein]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 05:58, 18 December 2019

OCA — Wed, 18 Dec 2019 05:58:33 GMT

←Older revision		Revision as of 05:58, 18 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6urh is ON HOLD	+	The entry 6urh is ON HOLD until Paper Publication

	Authors: Flyak, A.I., Bjorkman, P.J.		Authors: Flyak, A.I., Bjorkman, P.J.

OCA: Protected "6urh" [edit=sysop:move=sysop]

OCA — Wed, 30 Oct 2019 07:43:09 GMT

Protected "6urh" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:43, 30 October 2019

OCA: New page: '''Unreleased structure''' The entry 6urh is ON HOLD Authors: Flyak, A.I., Bjorkman, P.J. Description: Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis...

OCA — Wed, 30 Oct 2019 07:43:08 GMT

New page: '''Unreleased structure''' The entry 6urh is ON HOLD Authors: Flyak, A.I., Bjorkman, P.J. Description: Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis...

New page

'''Unreleased structure'''

The entry 6urh is ON HOLD

Authors: Flyak, A.I., Bjorkman, P.J.

Description: Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
[[Category: Unreleased Structures]]
[[Category: Bjorkman, P.J]]
[[Category: Flyak, A.I]]