6usq - Revision history

OCA at 07:57, 11 October 2023

OCA — Wed, 11 Oct 2023 07:57:36 GMT

←Older revision		Revision as of 07:57, 11 October 2023
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	<StructureSection load='6usq' size='340' side='right'caption='[[6usq]], [[Resolution\|resolution]] 3.62Å' scene=''>		<StructureSection load='6usq' size='340' side='right'caption='[[6usq]], [[Resolution\|resolution]] 3.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6usq]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Red_flour_beetle Red flour beetle~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6USQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6usq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tribolium_castaneum Tribolium castaneum] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6USQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.62Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TERT, TcasGA2_TC010963 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~7070 Red flour beetle])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6usq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usq OCA], [https://pdbe.org/6usq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6usq RCSB], [https://www.ebi.ac.uk/pdbsum/6usq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6usq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6usq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usq OCA], [~~http~~://pdbe.org/6usq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6usq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6usq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6usq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q0QHL8_TRICA Q0QHL8_TRICA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Telomerase\|Telomerase]]	+	*[[Telomerase 3D structures\|Telomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~RNA-directed DNA polymerase~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Red flour beetle~~]]	+	[[Category: Tribolium castaneum]]
-	[[Category: Freudenthal~~, B D~~]]	+	[[Category: Freudenthal BD]]
-	[[Category: Khoang~~, T H~~]]	+	[[Category: Khoang TH]]
-	[[Category: Schaich~~, M A]]~~	+	[[Category: Schaich MA]]
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Polymerase]]~~	+
-	~~[[Category: Reverse transcriptase]]~~	+
-	~~[[Category: Telomerase]]~~	+
-	~~[[Category: Transferase-rna-dna complex~~]]	+

OCA at 09:03, 6 January 2021

OCA — Wed, 06 Jan 2021 09:03:48 GMT

←Older revision		Revision as of 09:03, 6 January 2021
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	==Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA==		==Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA==
-	<StructureSection load='6usq' size='340' side='right'caption='[[6usq]]' scene=''>	+	<StructureSection load='6usq' size='340' side='right'caption='[[6usq]], [[Resolution\|resolution]] 3.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6USQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6usq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Red_flour_beetle Red flour beetle]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6USQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6usq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usq OCA], [http://pdbe.org/6usq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6usq RCSB], [http://www.ebi.ac.uk/pdbsum/6usq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6usq ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT, TcasGA2_TC010963 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7070 Red flour beetle])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6usq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usq OCA], [http://pdbe.org/6usq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6usq RCSB], [http://www.ebi.ac.uk/pdbsum/6usq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6usq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for the proper capping of telomeric sequences by shelterin. Unfortunately, how telomerase selects correct nucleotides is unknown. Here, we determined structures of Tribolium castaneum telomerase reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coordination, triphosphate binding, and RNA template stabilization. We found that TERT inserts a mismatch or ribonucleotide ~1 in 10,000 and ~1 in 14,000 insertion events, respectively. At biological ribonucleotide concentrations, these rates translate to ~40 ribonucleotides inserted per 10 kilobases. Human telomerase assays determined a conserved tyrosine steric gate regulates ribonucleotide insertion into telomeres. Cumulatively, our work provides insight into how telomerase selects the proper nucleotide to maintain telomere integrity.
		+
		+	Mechanisms of nucleotide selection by telomerase.,Schaich MA, Sanford SL, Welfer GA, Johnson SA, Khoang TH, Opresko PL, Freudenthal BD Elife. 2020 Jun 5;9. pii: 55438. doi: 10.7554/eLife.55438. PMID:32501800<ref>PMID:32501800</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6usq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Telomerase\|Telomerase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Freudenthal BD]]	+	[[Category: RNA-directed DNA polymerase]]
-	[[Category: Khoang TH]]	+	[[Category: Red flour beetle]]
-	[[Category: Schaich MA]]	+	[[Category: Freudenthal, B D]]
		+	[[Category: Khoang, T H]]
		+	[[Category: Schaich, M A]]
		+	[[Category: Nuclear protein]]
		+	[[Category: Polymerase]]
		+	[[Category: Reverse transcriptase]]
		+	[[Category: Telomerase]]
		+	[[Category: Transferase-rna-dna complex]]

OCA at 10:12, 17 June 2020

OCA — Wed, 17 Jun 2020 10:12:43 GMT

←Older revision		Revision as of 10:12, 17 June 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6usq is ~~ON HOLD until Paper Publication~~	+	==Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA==
-		+	<StructureSection load='6usq' size='340' side='right'caption='[[6usq]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6USQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6usq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usq OCA], [http://pdbe.org/6usq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6usq RCSB], [http://www.ebi.ac.uk/pdbsum/6usq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6usq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Freudenthal BD]]
		+	[[Category: Khoang TH]]
		+	[[Category: Schaich MA]]

OCA: Protected "6usq" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2019 05:20:11 GMT

Protected "6usq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 6 November 2019

OCA: New page: '''Unreleased structure''' The entry 6usq is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Nov 2019 05:20:09 GMT

New page: '''Unreleased structure''' The entry 6usq is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6usq is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]