6uuh - Revision history

OCA at 07:58, 11 October 2023

OCA — Wed, 11 Oct 2023 07:58:39 GMT

←Older revision		Revision as of 07:58, 11 October 2023
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-	====	+	==Crystal structure of broad and potent HIV-1 neutralizing antibody 438-B11==
-	<StructureSection load='6uuh' size='340' side='right'caption='[[6uuh]]' scene=''>	+	<StructureSection load='6uuh' size='340' side='right'caption='[[6uuh]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6uuh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UUH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uuh OCA], [~~http~~://pdbe.org/6uuh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6uuh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6uuh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6uuh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uuh OCA], [https://pdbe.org/6uuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uuh RCSB], [https://www.ebi.ac.uk/pdbsum/6uuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uuh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An oligomannose patch around the V3 base of HIV-1 envelope glycoprotein (Env) is recognized by multiple classes of broadly neutralizing antibodies (bNAbs). Here, we investigated the bNAb response to the V3 glycan supersite in an HIV-1-infected Chinese donor by Env-specific single B cell sorting, structural and functional studies, and longitudinal analysis of antibody and virus repertoires. Monoclonal antibodies 438-B11 and 438-D5 were isolated that potently neutralize HIV-1 with moderate breadth, are encoded by the VH1-69 germline gene, and have a disulfide-linked long HCDR3 loop. Crystal structures of Env-bound and unbound antibodies revealed heavy chain-mediated recognition of the glycan supersite with a unique angle of approach and a critical role of the intra-HCDR3 disulfide. The mechanism of viral escape was examined via single-genome amplification/sequencing and glycan mutations around the N332 supersite. Our findings further emphasize the V3 glycan supersite as a prominent target for Env-based vaccine design.
		+
		+	A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite.,Kumar S, Ju B, Shapero B, Lin X, Ren L, Zhang L, Li D, Zhou Z, Feng Y, Sou C, Mann CJ, Hao Y, Sarkar A, Hou J, Nunnally C, Hong K, Wang S, Ge X, Su B, Landais E, Sok D, Zwick MB, He L, Zhu J, Wilson IA, Shao Y Sci Adv. 2020 Sep 16;6(38). pii: 6/38/eabb1328. doi: 10.1126/sciadv.abb1328., Print 2020 Sep. PMID:32938661<ref>PMID:32938661</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6uuh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Streptococcus sp. 'group G']]
		+	[[Category: Kumar S]]
		+	[[Category: Wilson IA]]

OCA at 11:11, 23 September 2020

OCA — Wed, 23 Sep 2020 11:11:05 GMT

←Older revision		Revision as of 11:11, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6uuh ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6uuh' size='340' side='right'caption='[[6uuh]]' scene=''>
-	~~Authors~~: ~~Kumar, S~~.~~, Wilson, I~~.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of broad and potent HIV~~-~~1 neutralizing antibody 438-B11~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uuh OCA], [http://pdbe.org/6uuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uuh RCSB], [http://www.ebi.ac.uk/pdbsum/6uuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uuh ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Wilson, I.A~~]]	+	__TOC__
-	[[Category: ~~Kumar, S~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:37, 27 May 2020

OCA — Wed, 27 May 2020 04:37:14 GMT

←Older revision		Revision as of 04:37, 27 May 2020
Line 3:		Line 3:
	The entry 6uuh is ON HOLD until Paper Publication		The entry 6uuh is ON HOLD until Paper Publication

-	Authors:	+	Authors: Kumar, S., Wilson, I.A.

-	Description:	+	Description: Crystal structure of broad and potent HIV-1 neutralizing antibody 438-B11
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Wilson, I.A]]
		+	[[Category: Kumar, S]]

OCA at 13:28, 29 January 2020

OCA — Wed, 29 Jan 2020 13:28:15 GMT

←Older revision		Revision as of 13:28, 29 January 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6uuh is ON HOLD	+	The entry 6uuh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6uuh" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2019 05:25:21 GMT

Protected "6uuh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 6 November 2019

OCA: New page: '''Unreleased structure''' The entry 6uuh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Nov 2019 05:25:19 GMT

New page: '''Unreleased structure''' The entry 6uuh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6uuh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]