OCA at 08:03, 11 October 2023

OCA — Wed, 11 Oct 2023 08:03:03 GMT

←Older revision		Revision as of 08:03, 11 October 2023
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	==Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580==		==Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580==
-	<StructureSection load='6v34' size='340' side='right'caption='[[6v34]]' scene=''>	+	<StructureSection load='6v34' size='340' side='right'caption='[[6v34]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V34 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6V34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6v34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V34 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6v34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v34 OCA], [~~http~~://pdbe.org/6v34 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6v34 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6v34 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6v34 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QOP:6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide'>QOP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v34 OCA], [https://pdbe.org/6v34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v34 RCSB], [https://www.ebi.ac.uk/pdbsum/6v34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v34 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/BRAF_HUMAN BRAF_HUMAN] Note=Defects in BRAF are found in a wide range of cancers.<ref>PMID:18974108</ref> Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].<ref>PMID:18974108</ref> Defects in BRAF are involved in lung cancer (LNCR) [MIM:[https://omim.org/entry/211980 211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.<ref>PMID:18974108</ref> <ref>PMID:12460919</ref> Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:[https://omim.org/entry/605027 605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.<ref>PMID:18974108</ref> <ref>PMID:14612909</ref> Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:[https://omim.org/entry/115150 115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.<ref>PMID:18974108</ref> Defects in BRAF are the cause of Noonan syndrome type 7 (NS7) [MIM:[https://omim.org/entry/613706 613706]. Noonan syndrome is a disorder characterized by facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable intellectual deficits.<ref>PMID:18974108</ref> <ref>PMID:19206169</ref> Defects in BRAF are the cause of LEOPARD syndrome type 3 (LEOPARD3) [MIM:[https://omim.org/entry/613707 613707]. LEOPARD3 is a disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness.<ref>PMID:18974108</ref> <ref>PMID:19206169</ref> Note=A chromosomal aberration involving BRAF is found in pilocytic astrocytomas. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation.<ref>PMID:18974108</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BRAF_HUMAN BRAF_HUMAN] Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eck MJ]]		[[Category: Eck MJ]]
	[[Category: Gonzalez Del-Pino G]]		[[Category: Gonzalez Del-Pino G]]
	[[Category: Li K]]		[[Category: Li K]]

OCA at 07:45, 2 December 2020

OCA — Wed, 02 Dec 2020 07:45:09 GMT

←Older revision		Revision as of 07:45, 2 December 2020
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-	'''Unreleased structure'''

-	~~The entry 6v34 is ON HOLD until Paper Publication~~	+	==Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580==
-		+	<StructureSection load='6v34' size='340' side='right'caption='[[6v34]]' scene=''>
-	~~Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V34 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V34 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v34 OCA], [http://pdbe.org/6v34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v34 RCSB], [http://www.ebi.ac.uk/pdbsum/6v34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v34 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: Li, K]]	+	__TOC__
-	[[Category: Eck~~, M.J~~]]	+	</StructureSection>
-	[[Category: Gonzalez Del-Pino, G]]	+	[[Category: Large Structures]]
		+	[[Category: Eck MJ]]
		+	[[Category: Gonzalez Del-Pino G]]
		+	[[Category: Li K]]

OCA at 14:11, 22 January 2020

OCA — Wed, 22 Jan 2020 14:11:25 GMT

←Older revision		Revision as of 14:11, 22 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v34 is ON HOLD	+	The entry 6v34 is ON HOLD until Paper Publication

	Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J.		Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J.

OCA: Protected "6v34" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2019 06:38:54 GMT

Protected "6v34" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 4 December 2019

OCA: New page: '''Unreleased structure''' The entry 6v34 is ON HOLD Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J. Description: Crystal structure of BRAF V600E oncogenic mutant in complex with TAK...

OCA — Wed, 04 Dec 2019 06:38:52 GMT

New page: '''Unreleased structure''' The entry 6v34 is ON HOLD Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J. Description: Crystal structure of BRAF V600E oncogenic mutant in complex with TAK...

New page

'''Unreleased structure'''

The entry 6v34 is ON HOLD

Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J.

Description: Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580
[[Category: Unreleased Structures]]
[[Category: Li, K]]
[[Category: Eck, M.J]]
[[Category: Gonzalez Del-Pino, G]]

6v34 - Revision history

OCA at 08:03, 11 October 2023

OCA at 07:45, 2 December 2020

OCA at 14:11, 22 January 2020

OCA: Protected "6v34" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6v34 is ON HOLD Authors: Gonzalez Del-Pino, G., Li, K., Eck, M.J. Description: Crystal structure of BRAF V600E oncogenic mutant in complex with TAK...