6v3w - Revision history

OCA at 08:03, 11 October 2023

OCA — Wed, 11 Oct 2023 08:03:20 GMT

←Older revision		Revision as of 08:03, 11 October 2023
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	<StructureSection load='6v3w' size='340' side='right'caption='[[6v3w]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='6v3w' size='340' side='right'caption='[[6v3w]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6v3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6v3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V3W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=QO4:5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one'>QO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.04Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP12, ZC3HDC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=QO4:5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one'>QO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [https://pdbe.org/6v3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [https://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [https://pdbe.org/6v3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [https://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PAR12_HUMAN PAR12_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6v3w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6v3w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gozgit~~, J M~~]]	+	[[Category: Gozgit JM]]
-	[[Category: Kuntz~~, K W~~]]	+	[[Category: Kuntz KW]]
-	[[Category: Swinger~~, K K~~]]	+	[[Category: Swinger KK]]
-	[[Category: Vasbinder~~, M M~~]]	+	[[Category: Vasbinder MM]]
-	[[Category: Wigle~~, T J]]~~	+	[[Category: Wigle TJ]]
-	~~[[Category: Adp-ribosyltransferase activity]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:26, 25 August 2021

OCA — Wed, 25 Aug 2021 06:26:00 GMT

←Older revision		Revision as of 06:26, 25 August 2021
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [https://pdbe.org/6v3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [https://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [https://pdbe.org/6v3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [https://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition of PARP7 restores type I interferon (IFN) signaling responses to nucleic acids in tumor models. Restored signaling can directly inhibit cell proliferation and activate the immune system, both of which contribute to tumor regression. Oral dosing of the PARP7 small-molecule inhibitor, RBN-2397, results in complete tumor regression in a lung cancer xenograft and induces tumor-specific adaptive immune memory in an immunocompetent mouse cancer model, dependent on inducing type I IFN signaling in tumor cells. PARP7 is a therapeutic target whose inhibition induces both cancer cell-autonomous and immune stimulatory effects via enhanced IFN signaling. These data support the targeting of a monoPARP in cancer and introduce a potent and selective PARP7 inhibitor to enter clinical development.
		+
		+	PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.,Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H Cancer Cell. 2021 Jul 22. pii: S1535-6108(21)00340-8. doi:, 10.1016/j.ccell.2021.06.018. PMID:34375612<ref>PMID:34375612</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6v3w" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:14, 18 August 2021

OCA — Wed, 18 Aug 2021 06:14:21 GMT

←Older revision		Revision as of 06:14, 18 August 2021
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	==Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397==		==Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397==
-	<StructureSection load='6v3w' size='340' side='right'caption='[[6v3w]]' scene=''>	+	<StructureSection load='6v3w' size='340' side='right'caption='[[6v3w]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6V3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6v3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V3W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [~~http~~://pdbe.org/6v3w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=QO4:5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one'>QO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP12, ZC3HDC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [https://pdbe.org/6v3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [https://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gozgit JM]]	+	[[Category: Gozgit, J M]]
-	[[Category: Kuntz KW]]	+	[[Category: Kuntz, K W]]
-	[[Category: Swinger KK]]	+	[[Category: Swinger, K K]]
-	[[Category: Vasbinder MM]]	+	[[Category: Vasbinder, M M]]
-	[[Category: Wigle TJ]]	+	[[Category: Wigle, T J]]
		+	[[Category: Adp-ribosyltransferase activity]]
		+	[[Category: Transferase]]

OCA at 12:31, 16 December 2020

OCA — Wed, 16 Dec 2020 12:31:17 GMT

←Older revision		Revision as of 12:31, 16 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6v3w is ~~ON HOLD until Paper Publication~~	+	==Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397==
-		+	<StructureSection load='6v3w' size='340' side='right'caption='[[6v3w]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V3W FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3w OCA], [http://pdbe.org/6v3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v3w RCSB], [http://www.ebi.ac.uk/pdbsum/6v3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3w ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gozgit JM]]
		+	[[Category: Kuntz KW]]
		+	[[Category: Swinger KK]]
		+	[[Category: Vasbinder MM]]
		+	[[Category: Wigle TJ]]

OCA at 06:08, 8 January 2020

OCA — Wed, 08 Jan 2020 06:08:08 GMT

←Older revision		Revision as of 06:08, 8 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v3w is ON HOLD	+	The entry 6v3w is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6v3w" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2019 06:41:11 GMT

Protected "6v3w" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:41, 4 December 2019

OCA: New page: '''Unreleased structure''' The entry 6v3w is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Dec 2019 06:41:09 GMT

New page: '''Unreleased structure''' The entry 6v3w is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6v3w is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]