OCA at 08:03, 11 October 2023

OCA — Wed, 11 Oct 2023 08:03:42 GMT

←Older revision		Revision as of 08:03, 11 October 2023
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	==Trichuris suis BCL-2==		==Trichuris suis BCL-2==
-	<StructureSection load='6v4m' size='340' side='right'caption='[[6v4m]]' scene=''>	+	<StructureSection load='6v4m' size='340' side='right'caption='[[6v4m]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V4M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6V4M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6v4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichuris_suis Trichuris suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V4M FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6v4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v4m OCA], [~~http~~://pdbe.org/6v4m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6v4m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6v4m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6v4m ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.599Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v4m OCA], [https://pdbe.org/6v4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v4m RCSB], [https://www.ebi.ac.uk/pdbsum/6v4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v4m ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A085NFU1_9BILA A0A085NFU1_9BILA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C. elegans apoptosis has several unique features compared with human apoptosis. To date, there has been no detailed analysis of apoptosis regulators in nematodes other than C. elegans. Here, we discovered BCL-2 orthologues in 89 free-living and parasitic nematode taxa representing four evolutionary clades (I, III, IV and V). Unlike in C. elegans, 15 species possess multiple (two to five) BCL-2-like proteins, and some do not have any recognisable BCL-2 sequences. Functional studies provided no evidence that BAX/BAK proteins have evolved in nematodes, and structural studies of a BCL-2 protein from the basal clade I revealed it lacks a functionally important feature of the C. elegans orthologue. Clade I CED-4/APAF-1 proteins also possess WD40-repeat sequences associated with apoptosome assembly, not present in C. elegans, or other nematode taxa studied.
		+
		+	Diversity in the intrinsic apoptosis pathway of nematodes.,Young ND, Harris TJ, Evangelista M, Tran S, Wouters MA, Soares da Costa TP, Kershaw NJ, Gasser RB, Smith BJ, Lee EF, Fairlie WD Commun Biol. 2020 Aug 28;3(1):478. doi: 10.1038/s42003-020-01208-5. PMID:32859965<ref>PMID:32859965</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6v4m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Trichuris suis]]
	[[Category: Fairlie WD]]		[[Category: Fairlie WD]]
	[[Category: Lee EF]]		[[Category: Lee EF]]
	[[Category: Smith BJ]]		[[Category: Smith BJ]]

OCA at 06:19, 7 October 2020

OCA — Wed, 07 Oct 2020 06:19:00 GMT

←Older revision		Revision as of 06:19, 7 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6v4m is ~~ON HOLD until Paper Publication~~	+	==Trichuris suis BCL-2==
-		+	<StructureSection load='6v4m' size='340' side='right'caption='[[6v4m]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V4M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V4M FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v4m OCA], [http://pdbe.org/6v4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v4m RCSB], [http://www.ebi.ac.uk/pdbsum/6v4m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v4m ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fairlie WD]]
		+	[[Category: Lee EF]]
		+	[[Category: Smith BJ]]

OCA at 07:29, 25 December 2019

OCA — Wed, 25 Dec 2019 07:29:26 GMT

←Older revision		Revision as of 07:29, 25 December 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v4m is ON HOLD	+	The entry 6v4m is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6v4m" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2019 06:43:26 GMT

Protected "6v4m" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 4 December 2019

OCA: New page: '''Unreleased structure''' The entry 6v4m is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Dec 2019 06:43:24 GMT

New page: '''Unreleased structure''' The entry 6v4m is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6v4m is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6v4m - Revision history

OCA at 08:03, 11 October 2023

OCA at 06:19, 7 October 2020

OCA at 07:29, 25 December 2019

OCA: Protected "6v4m" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6v4m is ON HOLD Authors: Description: Category: Unreleased Structures