6v5k - Revision history

OCA at 08:04, 11 October 2023

OCA — Wed, 11 Oct 2023 08:04:08 GMT

←Older revision		Revision as of 08:04, 11 October 2023
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-	====	+	==Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*==
-	<StructureSection load='6v5k' size='340' side='right'caption='[[6v5k]]' scene=''>	+	<StructureSection load='6v5k' size='340' side='right'caption='[[6v5k]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6v5k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V5K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6v5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v5k OCA], [~~http~~://pdbe.org/6v5k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6v5k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6v5k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6v5k ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.69Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KX:2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]CYTIDINE'>0KX</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=QRV:2-amino-9-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)-7-{2-[(2-hydroxyethyl)(phenyl)amino]ethyl}-6-oxo-6,9-dihydro-1H-purin-7-ium'>QRV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v5k OCA], [https://pdbe.org/6v5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v5k RCSB], [https://www.ebi.ac.uk/pdbsum/6v5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v5k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] Defects in POLH are the cause of xeroderma pigmentosum variant type (XPV) [MIM:[https://omim.org/entry/278750 278750]; also designated as XP-V. Xeroderma pigmentosum (XP) is an autosomal recessive disease due to deficient nucleotide excision repair. It is characterized by hypersensitivity of the skin to sunlight, followed by high incidence of skin cancer and frequent neurologic abnormalities. XPV shows normal nucleotide excision repair, but an exaggerated delay in recovery of replicative DNA synthesis. Most XPV patients do not develop clinical symptoms and skin neoplasias until a later age. Clinical manifestations are limited to photo-induced deterioration of the skin and eyes.<ref>PMID:10385124</ref> <ref>PMID:10398605</ref> <ref>PMID:11032022</ref> <ref>PMID:11121129</ref> <ref>PMID:11773631</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.<ref>PMID:10385124</ref> <ref>PMID:11743006</ref> <ref>PMID:11376341</ref> <ref>PMID:14630940</ref> <ref>PMID:14734526</ref>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Jung H]]
		+	[[Category: Lee S]]

OCA at 06:36, 9 December 2020

OCA — Wed, 09 Dec 2020 06:36:16 GMT

←Older revision		Revision as of 06:36, 9 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6v5k ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6v5k' size='340' side='right'caption='[[6v5k]]' scene=''>
-	~~Authors~~: ~~Jung, H~~.~~, Lee, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of human DNA polymerase eta complexed with N7~~-nitrogen half-mustard guanine (NHMG) and dCTP*	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v5k OCA], [http://pdbe.org/6v5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v5k RCSB], [http://www.ebi.ac.uk/pdbsum/6v5k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v5k ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Lee, S~~]]	+	__TOC__
-	[[Category: ~~Jung, H~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 03:49, 13 May 2020

OCA — Wed, 13 May 2020 03:49:29 GMT

←Older revision		Revision as of 03:49, 13 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v5k is ON HOLD	+	The entry 6v5k is ON HOLD until Paper Publication

	Authors: Jung, H., Lee, S.		Authors: Jung, H., Lee, S.
Line 7:		Line 7:
	Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*		Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Jung, H]]
	[[Category: Lee, S]]		[[Category: Lee, S]]
		+	[[Category: Jung, H]]

OCA at 14:12, 22 January 2020

OCA — Wed, 22 Jan 2020 14:12:18 GMT

←Older revision		Revision as of 14:12, 22 January 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v5k is ON HOLD ~~until Paper Publication~~	+	The entry 6v5k is ON HOLD

	Authors: Jung, H., Lee, S.		Authors: Jung, H., Lee, S.

OCA at 06:47, 1 January 2020

OCA — Wed, 01 Jan 2020 06:47:18 GMT

←Older revision		Revision as of 06:47, 1 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6v5k is ON HOLD	+	The entry 6v5k is ON HOLD until Paper Publication

	Authors: Jung, H., Lee, S.		Authors: Jung, H., Lee, S.
Line 7:		Line 7:
	Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*		Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Lee, S]]
	[[Category: Jung, H]]		[[Category: Jung, H]]
		+	[[Category: Lee, S]]

OCA: Protected "6v5k" [edit=sysop:move=sysop]

OCA — Wed, 11 Dec 2019 13:47:00 GMT

Protected "6v5k" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:47, 11 December 2019

OCA: New page: '''Unreleased structure''' The entry 6v5k is ON HOLD Authors: Jung, H., Lee, S. Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guani...

OCA — Wed, 11 Dec 2019 13:46:58 GMT

New page: '''Unreleased structure''' The entry 6v5k is ON HOLD Authors: Jung, H., Lee, S. Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guani...

New page

'''Unreleased structure'''

The entry 6v5k is ON HOLD

Authors: Jung, H., Lee, S.

Description: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
[[Category: Unreleased Structures]]
[[Category: Lee, S]]
[[Category: Jung, H]]