6vai - Revision history

OCA at 07:06, 11 April 2020

OCA — Sat, 11 Apr 2020 07:06:12 GMT

←Older revision		Revision as of 07:06, 11 April 2020
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	<SX load='6vai' size='340' side='right' viewer='molstar' caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>		<SX load='6vai' size='340' side='right' viewer='molstar' caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6VAI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VAI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALHM2, FAM26B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALHM2, FAM26B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6vai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vai OCA], [http://pdbe.org/6vai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vai RCSB], [http://www.ebi.ac.uk/pdbsum/6vai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vai ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vai OCA], [http://pdbe.org/6vai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vai RCSB], [http://www.ebi.ac.uk/pdbsum/6vai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vai ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:24, 7 March 2020

OCA — Sat, 07 Mar 2020 01:24:42 GMT

←Older revision		Revision as of 01:24, 7 March 2020
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	==Cryo-EM structure of a dimer of undecameric human CALHM2==		==Cryo-EM structure of a dimer of undecameric human CALHM2==
-	<~~StructureSection~~ load='6vai' size='340' side='right'caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>	+	<SX load='6vai' size='340' side='right' viewer='molstar' caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VAI FirstGlance]. <br>		<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VAI FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 04:48, 13 February 2020

OCA — Thu, 13 Feb 2020 04:48:39 GMT

←Older revision		Revision as of 04:48, 13 February 2020
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	<StructureSection load='6vai' size='340' side='right'caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>		<StructureSection load='6vai' size='340' side='right'caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VAI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VAI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vai OCA], [http://pdbe.org/6vai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vai RCSB], [http://www.ebi.ac.uk/pdbsum/6vai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vai ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALHM2, FAM26B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vai OCA], [http://pdbe.org/6vai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vai RCSB], [http://www.ebi.ac.uk/pdbsum/6vai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vai ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CAHM2_HUMAN CAHM2_HUMAN]] Pore-forming subunit of a voltage-gated ion channel.[UniProtKB:Q8IU99]		[[http://www.uniprot.org/uniprot/CAHM2_HUMAN CAHM2_HUMAN]] Pore-forming subunit of a voltage-gated ion channel.[UniProtKB:Q8IU99]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The biological membranes of many cell types contain large-pore channels through which a wide variety of ions and metabolites permeate. Examples include connexin, innexin and pannexin, which form gap junctions and/or bona fide cell surface channels. The most recently identified large-pore channels are the calcium homeostasis modulators (CALHMs), through which ions and ATP permeate in a voltage-dependent manner to control neuronal excitability, taste signaling and pathologies of depression and Alzheimer's disease. Despite such critical biological roles, the structures and patterns of their oligomeric assembly remain unclear. Here, we reveal the structures of two CALHMs, chicken CALHM1 and human CALHM2, by single-particle cryo-electron microscopy (cryo-EM), which show novel assembly of the four transmembrane helices into channels of octamers and undecamers, respectively. Furthermore, molecular dynamics simulations suggest that lipids can favorably assemble into a bilayer within the larger CALHM2 pore, but not within CALHM1, demonstrating the potential correlation between pore size, lipid accommodation and channel activity.
		+
		+	Structure and assembly of calcium homeostasis modulator proteins.,Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H Nat Struct Mol Biol. 2020 Feb;27(2):150-159. doi: 10.1038/s41594-019-0369-9. Epub, 2020 Jan 27. PMID:31988524<ref>PMID:31988524</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vai" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chou, T H]]		[[Category: Chou, T H]]

OCA at 15:46, 29 January 2020

OCA — Wed, 29 Jan 2020 15:46:43 GMT

←Older revision		Revision as of 15:46, 29 January 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vai ~~is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of a dimer of undecameric human CALHM2==
-		+	<StructureSection load='6vai' size='340' side='right'caption='[[6vai]], [[Resolution\|resolution]] 3.68Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6vai]] is a 22 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VAI FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vai OCA], [http://pdbe.org/6vai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vai RCSB], [http://www.ebi.ac.uk/pdbsum/6vai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vai ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAHM2_HUMAN CAHM2_HUMAN]] Pore-forming subunit of a voltage-gated ion channel.[UniProtKB:Q8IU99]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chou, T H]]
		+	[[Category: Furukawa, H]]
		+	[[Category: Syrjanen, J L]]
		+	[[Category: Assembly]]
		+	[[Category: Calcium]]
		+	[[Category: Gap junction]]
		+	[[Category: Membrane protein]]
		+	[[Category: Taste]]

OCA at 14:16, 22 January 2020

OCA — Wed, 22 Jan 2020 14:16:06 GMT

←Older revision		Revision as of 14:16, 22 January 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vai is ON HOLD	+	The entry 6vai is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vai" [edit=sysop:move=sysop]

OCA — Wed, 25 Dec 2019 07:35:52 GMT

Protected "6vai" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:35, 25 December 2019

OCA: New page: '''Unreleased structure''' The entry 6vai is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Dec 2019 07:35:50 GMT

New page: '''Unreleased structure''' The entry 6vai is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vai is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]