6vcw - Revision history

OCA at 08:09, 11 October 2023

OCA — Wed, 11 Oct 2023 08:09:17 GMT

←Older revision		Revision as of 08:09, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6vcw' size='340' side='right'caption='[[6vcw]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='6vcw' size='340' side='right'caption='[[6vcw]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vcw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Barrel_medic Barrel medic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6VCW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vcw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_truncatula Medicago truncatula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VCW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~11432371, MTR_7g102120, MtrunA17_Chr7g0264651 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=3880 Barrel medic])</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcw OCA], [https://pdbe.org/6vcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vcw RCSB], [https://www.ebi.ac.uk/pdbsum/6vcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6vcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcw OCA], [~~http~~://pdbe.org/6vcw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vcw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vcw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/G7L3W1_MEDTR G7L3W1_MEDTR]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.[RuleBase:RU000541]	+	[https://www.uniprot.org/uniprot/G7L3W1_MEDTR G7L3W1_MEDTR] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.[RuleBase:RU000541]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6vcw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6vcw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S-adenosylmethionine synthetase 3D structures\|S-adenosylmethionine synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Barrel medic]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Methionine adenosyltransferase~~]]	+	[[Category: Medicago truncatula]]
-	[[Category: Dauter, Z]]	+	[[Category: Dauter Z]]
-	[[Category: Ruszkowski, M]]	+	[[Category: Ruszkowski M]]
-	[[Category: Sekula, B]]	+	[[Category: Sekula B]]
-	~~[[Category: Sam synthase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:10, 11 March 2020

OCA — Wed, 11 Mar 2020 08:10:56 GMT

←Older revision		Revision as of 08:10, 11 March 2020
Line 3:		Line 3:
	<StructureSection load='6vcw' size='340' side='right'caption='[[6vcw]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='6vcw' size='340' side='right'caption='[[6vcw]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vcw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VCW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vcw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barrel_medic Barrel medic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VCW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">11432371, MTR_7g102120, MtrunA17_Chr7g0264651 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3880 Barrel medic])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcw OCA], [http://pdbe.org/6vcw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vcw RCSB], [http://www.ebi.ac.uk/pdbsum/6vcw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcw OCA], [http://pdbe.org/6vcw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vcw RCSB], [http://www.ebi.ac.uk/pdbsum/6vcw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcw ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Barrel medic]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Methionine adenosyltransferase]]		[[Category: Methionine adenosyltransferase]]

OCA at 09:27, 26 February 2020

OCA — Wed, 26 Feb 2020 09:27:33 GMT

←Older revision		Revision as of 09:27, 26 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6vcw is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Medicago truncatula S-adenosylmethionine Synthase 3A (MtMAT3A)==
		+	<StructureSection load='6vcw' size='340' side='right'caption='[[6vcw]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6vcw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VCW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcw OCA], [http://pdbe.org/6vcw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vcw RCSB], [http://www.ebi.ac.uk/pdbsum/6vcw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G7L3W1_MEDTR G7L3W1_MEDTR]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.[RuleBase:RU000541]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S-adenosylmethionine synthases (MATs) are responsible for production of S-adenosylmethionine, the cofactor essential for various methylation reactions, production of polyamines and phytohormone ethylene, etc. Plants have two distinct MAT types (I and II). This work presents the structural analysis of MATs from Arabidopsis thaliana (AtMAT1 and AtMAT2, both type I) and Medicago truncatula (MtMAT3a, type II), which, unlike most MATs, are dimers where three-domain subunits are sandwiched flat with one another. Although MAT types are very similar, their subunits are differently oriented within the dimer. Structural snapshots along the enzymatic reaction reveal the exact conformation of precatalytic methionine in the active site and show a binding niche, characteristic only for plant MATs, that may serve as a lock of the gate loop. Nevertheless, plants, in contrary to mammals, lack the MAT regulatory subunit, and the regulation of plant MAT activity is still puzzling. Our structures open a possibility of an allosteric activity regulation of type I plant MATs by linear compounds, like polyamines, which would tighten the relationship between S-adenosylmethionine and polyamine biosynthesis.

-	~~Authors~~: ~~Sekula~~, B., Ruszkowski, M., Dauter, Z.	+	S-adenosylmethionine synthases in plants: Structural characterization of type I and II isoenzymes from Arabidopsis thaliana and Medicago truncatula.,Sekula B, Ruszkowski M, Dauter Z Int J Biol Macromol. 2020 Feb 11. pii: S0141-8130(20)30238-5. doi:, 10.1016/j.ijbiomac.2020.02.100. PMID:32057875<ref>PMID:32057875</ref>

-	~~Description: Crystal structure~~ of ~~Medicago truncatula~~ S-~~adenosylmethionine Synthase 3A (MtMAT3A)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Sekula, B]]~~	+	<div class="pdbe-citations 6vcw" style="background-color:#fffaf0;"></div>
-	~~[[Category: Ruszkowski, M~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Methionine adenosyltransferase]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
		+	[[Category: Ruszkowski, M]]
		+	[[Category: Sekula, B]]
		+	[[Category: Sam synthase]]
		+	[[Category: Transferase]]

OCA at 13:32, 29 January 2020

OCA — Wed, 29 Jan 2020 13:32:11 GMT

←Older revision		Revision as of 13:32, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vcw is ON HOLD	+	The entry 6vcw is ON HOLD until Paper Publication

	Authors: Sekula, B., Ruszkowski, M., Dauter, Z.		Authors: Sekula, B., Ruszkowski, M., Dauter, Z.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Sekula, B]]		[[Category: Sekula, B]]
-	[[Category: Dauter, Z]]
	[[Category: Ruszkowski, M]]		[[Category: Ruszkowski, M]]
		+	[[Category: Dauter, Z]]

OCA: Protected "6vcw" [edit=sysop:move=sysop]

OCA — Wed, 01 Jan 2020 06:51:46 GMT

Protected "6vcw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:51, 1 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vcw is ON HOLD Authors: Sekula, B., Ruszkowski, M., Dauter, Z. Description: Crystal structure of Medicago truncatula S-adenosylmethionine Synthase...

OCA — Wed, 01 Jan 2020 06:51:44 GMT

New page: '''Unreleased structure''' The entry 6vcw is ON HOLD Authors: Sekula, B., Ruszkowski, M., Dauter, Z. Description: Crystal structure of Medicago truncatula S-adenosylmethionine Synthase...

New page

'''Unreleased structure'''

The entry 6vcw is ON HOLD

Authors: Sekula, B., Ruszkowski, M., Dauter, Z.

Description: Crystal structure of Medicago truncatula S-adenosylmethionine Synthase 3A (MtMAT3A)
[[Category: Unreleased Structures]]
[[Category: Sekula, B]]
[[Category: Dauter, Z]]
[[Category: Ruszkowski, M]]