6vfp - Revision history

OCA at 08:11, 11 October 2023

OCA — Wed, 11 Oct 2023 08:11:04 GMT

←Older revision		Revision as of 08:11, 11 October 2023
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	<StructureSection load='6vfp' size='340' side='right'caption='[[6vfp]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='6vfp' size='340' side='right'caption='[[6vfp]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vfp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6VFP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VFP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6vfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vfp OCA], [~~http~~://pdbe.org/6vfp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vfp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vfp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vfp ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vfp OCA], [https://pdbe.org/6vfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vfp RCSB], [https://www.ebi.ac.uk/pdbsum/6vfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.	+	[https://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN] May be involved in cell-cell interaction processes and in cell adhesion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6vfp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6vfp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brasch, J]]	+	[[Category: Brasch J]]
-	[[Category: Harrison~~, O J~~]]	+	[[Category: Harrison OJ]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Cadherin extracellular region]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Homophilic adhesion/recognition calcium-dependent adhesion molecule]]~~	+
-	~~[[Category: Non-clustered delta1 family protocadherin~~]]	+

OCA at 07:30, 11 March 2020

OCA — Wed, 11 Mar 2020 07:30:58 GMT

←Older revision		Revision as of 07:30, 11 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vfp is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human protocadherin 1 EC1-EC4==
		+	<StructureSection load='6vfp' size='340' side='right'caption='[[6vfp]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6vfp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VFP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vfp OCA], [http://pdbe.org/6vfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vfp RCSB], [http://www.ebi.ac.uk/pdbsum/6vfp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vfp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Non-clustered delta1- and delta2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of delta1- and delta2-protocadherins, determined crystal structures of ectodomain complexes from each family, and assessed ectodomain assembly in reconstituted intermembrane junctions by cryoelectron tomography (cryo-ET). Homophilic trans (cell-cell) interactions were preferred for all delta-protocadherins, with additional weaker heterophilic interactions observed exclusively within each subfamily. As expected, delta1- and delta2-protocadherin trans dimers formed through antiparallel EC1-EC4 interfaces, like clustered protocadherins. However, no ectodomain-mediated cis (same-cell) interactions were detectable in solution; consistent with this, cryo-ET of reconstituted junctions revealed dense assemblies lacking the characteristic order observed for clustered protocadherins. Our results define non-clustered protocadherin binding properties and their structural basis, providing a foundation for interpreting their functional roles in neural patterning.

-	~~Authors~~:	+	Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered delta-Protocadherins.,Harrison OJ, Brasch J, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potter CS, Carragher B, Honig B, Shapiro L Cell Rep. 2020 Feb 25;30(8):2655-2671.e7. doi: 10.1016/j.celrep.2020.02.003. PMID:32101743<ref>PMID:32101743</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6vfp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brasch, J]]
		+	[[Category: Harrison, O J]]
		+	[[Category: Shapiro, L]]
		+	[[Category: Cadherin extracellular region]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Homophilic adhesion/recognition calcium-dependent adhesion molecule]]
		+	[[Category: Non-clustered delta1 family protocadherin]]

OCA at 06:13, 5 February 2020

OCA — Wed, 05 Feb 2020 06:13:28 GMT

←Older revision		Revision as of 06:13, 5 February 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vfp is ON HOLD	+	The entry 6vfp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vfp" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2020 14:23:01 GMT

Protected "6vfp" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:23, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vfp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Jan 2020 14:22:59 GMT

New page: '''Unreleased structure''' The entry 6vfp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vfp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]