6vjt - Revision history

OCA at 08:14, 11 October 2023

OCA — Wed, 11 Oct 2023 08:14:03 GMT

←Older revision		Revision as of 08:14, 11 October 2023
Line 1:		Line 1:

-	====	+	==Co-crystals of broadly neutralizing antibody with the linear epitope from Hepatitis B surface antigen==
-	<StructureSection load='6vjt' size='340' side='right'caption='[[6vjt]]' scene=''>	+	<StructureSection load='6vjt' size='340' side='right'caption='[[6vjt]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vjt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VJT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vjt OCA], [https://pdbe.org/6vjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vjt RCSB], [https://www.ebi.ac.uk/pdbsum/6vjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vjt ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.782Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vjt OCA], [https://pdbe.org/6vjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vjt RCSB], [https://www.ebi.ac.uk/pdbsum/6vjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vjt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A5A4RHH5_HBV A0A5A4RHH5_HBV] The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.[HAMAP-Rule:MF_04075] The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.[HAMAP-Rule:MF_04075]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although there is no effective cure for chronic hepatitis B virus (HBV) infection, antibodies are protective and correlate with recovery from infection. To examine the human antibody response to HBV, we screened 124 vaccinated and 20 infected, spontaneously recovered individuals. The selected individuals produced shared clones of broadly neutralizing antibodies (bNAbs) that targeted 3 non-overlapping epitopes on the HBV S antigen (HBsAg). Single bNAbs protected humanized mice against infection but selected for resistance mutations in mice with prior established infection. In contrast, infection was controlled by a combination of bNAbs targeting non-overlapping epitopes with complementary sensitivity to mutations that commonly emerge during human infection. The co-crystal structure of one of the bNAbs with an HBsAg peptide epitope revealed a stabilized hairpin loop. This structure, which contains residues frequently mutated in clinical immune escape variants, provides a molecular explanation for why immunotherapy for HBV infection may require combinations of complementary bNAbs.
		+
		+	A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations.,Wang Q, Michailidis E, Yu Y, Wang Z, Hurley AM, Oren DA, Mayer CT, Gazumyan A, Liu Z, Zhou Y, Schoofs T, Yao KH, Nieke JP, Wu J, Jiang Q, Zou C, Kabbani M, Quirk C, Oliveira T, Chhosphel K, Zhang Q, Schneider WM, Jahan C, Ying T, Horowitz J, Caskey M, Jankovic M, Robbiani DF, Wen Y, de Jong YP, Rice CM, Nussenzweig MC Cell Host Microbe. 2020 Aug 12;28(2):335-349.e6. doi: 10.1016/j.chom.2020.05.010., Epub 2020 Jun 5. PMID:32504577<ref>PMID:32504577</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vjt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hepatitis B virus]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Nussenzweig MC]]
		+	[[Category: Oren DA]]
		+	[[Category: Wang Q]]

OCA at 07:11, 16 March 2022

OCA — Wed, 16 Mar 2022 07:11:51 GMT

←Older revision		Revision as of 07:11, 16 March 2022
Line 3:		Line 3:
	<StructureSection load='6vjt' size='340' side='right'caption='[[6vjt]]' scene=''>		<StructureSection load='6vjt' size='340' side='right'caption='[[6vjt]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vjt OCA], [~~http~~://pdbe.org/6vjt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vjt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vjt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vjt ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vjt OCA], [https://pdbe.org/6vjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vjt RCSB], [https://www.ebi.ac.uk/pdbsum/6vjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vjt ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 11:16, 26 August 2020

OCA — Wed, 26 Aug 2020 11:16:22 GMT

←Older revision		Revision as of 11:16, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vjt ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6vjt' size='340' side='right'caption='[[6vjt]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vjt OCA], [http://pdbe.org/6vjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vjt RCSB], [http://www.ebi.ac.uk/pdbsum/6vjt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vjt ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:02, 11 March 2020

OCA — Wed, 11 Mar 2020 06:02:49 GMT

←Older revision		Revision as of 06:02, 11 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vjt is ON HOLD	+	The entry 6vjt is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vjt" [edit=sysop:move=sysop]

OCA — Wed, 29 Jan 2020 13:34:51 GMT

Protected "6vjt" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:34, 29 January 2020

OCA: New page: '''Unreleased structure''' The entry 6vjt is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Jan 2020 13:34:49 GMT

New page: '''Unreleased structure''' The entry 6vjt is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vjt is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]