OCA at 08:16, 11 October 2023

OCA — Wed, 11 Oct 2023 08:16:13 GMT

←Older revision		Revision as of 08:16, 11 October 2023
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	==Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434==		==Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434==
-	<StructureSection load='6vot' size='340' side='right'caption='[[6vot]]' scene=''>	+	<StructureSection load='6vot' size='340' side='right'caption='[[6vot]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VOT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VOT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vot]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VOT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vot OCA], [~~http~~://pdbe.org/6vot PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vot RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vot PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vot ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R7G:1-[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6+-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic+acid'>R7G</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vot OCA], [https://pdbe.org/6vot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vot RCSB], [https://www.ebi.ac.uk/pdbsum/6vot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vot ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FTSI_PSEAE FTSI_PSEAE] Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin (PubMed:20580675).[HAMAP-Rule:MF_02080]<ref>PMID:20580675</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel gamma-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of gamma-lactam YU253434, 1, are reported along with the finding that 1 is resistant to hydrolysis by all four classes of beta-lactamases. The druglike characteristics and mouse PK data are described along with the X-ray crystal structure of 1 binding to its target PBP3.
		+
		+	A gamma-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.,Goldberg JA, Nguyen H, Kumar V, Spencer EJ, Hoyer D, Marshall EK, Cmolik A, O'Shea M, Marshall SH, Hujer AM, Hujer KM, Rudin SD, Domitrovic TN, Bethel CR, Papp-Wallace KM, Logan LK, Perez F, Jacobs MR, van Duin D, Kreiswirth BM, Bonomo RA, Plummer MS, van den Akker F J Med Chem. 2020 Jun 11;63(11):5990-6002. doi: 10.1021/acs.jmedchem.0c00255. Epub, 2020 Jun 2. PMID:32420736<ref>PMID:32420736</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vot" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pseudomonas aeruginosa]]
	[[Category: Van den Akker F]]		[[Category: Van den Akker F]]

OCA at 05:34, 13 May 2020

OCA — Wed, 13 May 2020 05:34:38 GMT

←Older revision		Revision as of 05:34, 13 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vot ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434==
-		+	<StructureSection load='6vot' size='340' side='right'caption='[[6vot]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VOT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VOT FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vot OCA], [http://pdbe.org/6vot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vot RCSB], [http://www.ebi.ac.uk/pdbsum/6vot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vot ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Van den Akker F]]

OCA at 08:25, 18 March 2020

OCA — Wed, 18 Mar 2020 08:25:37 GMT

←Older revision		Revision as of 08:25, 18 March 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vot is ON HOLD	+	The entry 6vot is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vot" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2020 02:42:44 GMT

Protected "6vot" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:42, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vot is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 13 Feb 2020 02:42:42 GMT

New page: '''Unreleased structure''' The entry 6vot is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vot is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6vot - Revision history

OCA at 08:16, 11 October 2023

OCA at 05:34, 13 May 2020

OCA at 08:25, 18 March 2020

OCA: Protected "6vot" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6vot is ON HOLD Authors: Description: Category: Unreleased Structures