OCA at 07:09, 3 April 2024

OCA — Wed, 03 Apr 2024 07:09:29 GMT

←Older revision		Revision as of 07:09, 3 April 2024
Line 1:		Line 1:

	==TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 7-80, and in complex with AMP-PNP==		==TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 7-80, and in complex with AMP-PNP==
-	<StructureSection load='6vpl' size='340' side='right'caption='[[6vpl]]' scene=''>	+	<StructureSection load='6vpl' size='340' side='right'caption='[[6vpl]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vpl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VPL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpl OCA], [~~http~~://pdbe.org/6vpl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vpl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vpl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=R7D:N~2~-{(2R)-2-hydroxy-2-[4-(trifluoromethyl)phenyl]acetyl}-N-[(pyridin-2-yl)methyl]-L-cysteinamide'>R7D</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpl OCA], [https://pdbe.org/6vpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vpl RCSB], [https://www.ebi.ac.uk/pdbsum/6vpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref> [https://www.uniprot.org/uniprot/TPX2_HUMAN TPX2_HUMAN] Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.<ref>PMID:18663142</ref> <ref>PMID:19208764</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lim DC]]		[[Category: Lim DC]]
	[[Category: Yaffe MB]]		[[Category: Yaffe MB]]

OCA at 05:34, 5 August 2020

OCA — Wed, 05 Aug 2020 05:34:42 GMT

←Older revision		Revision as of 05:34, 5 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vpl ~~is ON HOLD until Paper Publication~~	+	==TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 7-80, and in complex with AMP-PNP==
-		+	<StructureSection load='6vpl' size='340' side='right'caption='[[6vpl]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VPL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpl OCA], [http://pdbe.org/6vpl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vpl RCSB], [http://www.ebi.ac.uk/pdbsum/6vpl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpl ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lim DC]]
		+	[[Category: Yaffe MB]]

OCA: Protected "6vpl" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2020 02:44:52 GMT

Protected "6vpl" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:44, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vpl is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 13 Feb 2020 02:44:50 GMT

New page: '''Unreleased structure''' The entry 6vpl is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vpl is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6vpl - Revision history

OCA at 07:09, 3 April 2024

OCA at 05:34, 5 August 2020

OCA: Protected "6vpl" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6vpl is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures