6vrw - Revision history

OCA at 05:47, 6 October 2021

OCA — Wed, 06 Oct 2021 05:47:43 GMT

←Older revision		Revision as of 05:47, 6 October 2021
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	<StructureSection load='6vrw' size='340' side='right'caption='[[6vrw]], [[Resolution\|resolution]] 3.71Å' scene=''>		<StructureSection load='6vrw' size='340' side='right'caption='[[6vrw]], [[Resolution\|resolution]] 3.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vrw]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vrw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VRW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrw OCA], [~~http~~://pdbe.org/6vrw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vrw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vrw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrw OCA], [https://pdbe.org/6vrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vrw RCSB], [https://www.ebi.ac.uk/pdbsum/6vrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibodies targeting the V1V2 apex of the HIV-1 envelope (Env) trimer comprise one of the most commonly elicited categories of broadly neutralizing antibodies. Structures of these antibodies indicate diverse modes of Env recognition typified by antibodies of the PG9 class and the PGT145 class. The mode of recognition, however, has been unclear for the most potent of the V1V2 apex-targeting antibodies, CAP256-VRC26.25 (named for donor-lineage.clone and referred to hereafter as VRC26.25). Here, we determine the cryoelectron microscopy structure at 3.7 A resolution of the antigen-binding fragment of VRC26.25 in complex with the Env trimer thought to have initiated the lineage. The 36-residue protruding loop of VRC26.25 displays recognition incorporating both strand-C interactions similar to the PG9 class and V1V2 apex insertion similar to the PGT145 class. Structural elements of separate antibody classes can thus intermingle to form a "combined" class, which in this case yields an antibody of extraordinary potency.
		+
		+	Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.,Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, Moore PL, Morris L, Shapiro L, Mascola JR, Kwong PD Cell Rep. 2020 Apr 7;31(1):107488. doi: 10.1016/j.celrep.2020.03.052. PMID:32268107<ref>PMID:32268107</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vrw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp120 3D structures\|Gp120 3D structures]]
		+	*[[Gp41 3D Structures\|Gp41 3D Structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:29, 8 April 2020

OCA — Wed, 08 Apr 2020 07:29:16 GMT

←Older revision		Revision as of 07:29, 8 April 2020
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-	==Cryo-EM structure of stabilized HIV-1 Env trimer CAP256 SU.wk34.80 SOSIP.RnS2==	+	==Cryo-EM structure of stabilized HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2==
	<StructureSection load='6vrw' size='340' side='right'caption='[[6vrw]], [[Resolution\|resolution]] 3.71Å' scene=''>		<StructureSection load='6vrw' size='340' side='right'caption='[[6vrw]], [[Resolution\|resolution]] 3.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vrw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6VRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vrw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VRW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6vrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrw OCA], [http://pdbe.org/6vrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vrw RCSB], [http://www.ebi.ac.uk/pdbsum/6vrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrw OCA], [http://pdbe.org/6vrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vrw RCSB], [http://www.ebi.ac.uk/pdbsum/6vrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrw ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 07:33, 11 March 2020

OCA — Wed, 11 Mar 2020 07:33:22 GMT

←Older revision		Revision as of 07:33, 11 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6vrw is ON HOLD~~	+	==Cryo-EM structure of stabilized HIV-1 Env trimer CAP256 SU.wk34.80 SOSIP.RnS2==
-		+	<StructureSection load='6vrw' size='340' side='right'caption='[[6vrw]], [[Resolution\|resolution]] 3.71Å' scene=''>
-	~~Authors: Gorman, J., Kwong, P.D.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6vrw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VRW FirstGlance]. <br>
-	~~Description:~~ Cryo-EM structure of stabilized HIV-1 Env trimer CAP256 SU.wk34.80 SOSIP.RnS2	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrw OCA], [http://pdbe.org/6vrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vrw RCSB], [http://www.ebi.ac.uk/pdbsum/6vrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrw ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Kwong~~, P.D]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gorman, J]]		[[Category: Gorman, J]]
		+	[[Category: Kwong, P D]]
		+	[[Category: Cap256]]
		+	[[Category: Hiv-1]]
		+	[[Category: Immune system]]
		+	[[Category: Sosip]]
		+	[[Category: Superinfecting]]
		+	[[Category: V1v2]]
		+	[[Category: Vaccine]]
		+	[[Category: Vrc26]]

OCA: Protected "6vrw" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2020 05:19:32 GMT

Protected "6vrw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 19 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vrw is ON HOLD Authors: Gorman, J., Kwong, P.D. Description: Cryo-EM structure of stabilized HIV-1 Env trimer CAP256 SU.wk34.80 SOSIP.RnS2 [[Categ...

OCA — Wed, 19 Feb 2020 05:19:30 GMT

New page: '''Unreleased structure''' The entry 6vrw is ON HOLD Authors: Gorman, J., Kwong, P.D. Description: Cryo-EM structure of stabilized HIV-1 Env trimer CAP256 SU.wk34.80 SOSIP.RnS2 [[Categ...

New page

'''Unreleased structure'''

The entry 6vrw is ON HOLD

Authors: Gorman, J., Kwong, P.D.

Description: Cryo-EM structure of stabilized HIV-1 Env trimer CAP256 SU.wk34.80 SOSIP.RnS2
[[Category: Unreleased Structures]]
[[Category: Kwong, P.D]]
[[Category: Gorman, J]]