6vuo - Revision history

OCA at 08:20, 11 October 2023

OCA — Wed, 11 Oct 2023 08:20:36 GMT

←Older revision		Revision as of 08:20, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6vuo' size='340' side='right'caption='[[6vuo]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6vuo' size='340' side='right'caption='[[6vuo]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vuo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vuo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VUO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.449Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~scFv ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vuo OCA], [https://pdbe.org/6vuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vuo RCSB], [https://www.ebi.ac.uk/pdbsum/6vuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vuo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vuo OCA], [https://pdbe.org/6vuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vuo RCSB], [https://www.ebi.ac.uk/pdbsum/6vuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vuo ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arnold, E]]	+	[[Category: Arnold E]]
-	[[Category: Chelsy, C]]	+	[[Category: Chelsy C]]
-	~~[[Category: Antibody fragment]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 14:51, 17 June 2021

OCA — Thu, 17 Jun 2021 14:51:55 GMT

←Older revision		Revision as of 14:51, 17 June 2021
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	</div>		</div>
	<div class="pdbe-citations 6vuo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6vuo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:51, 10 March 2021

OCA — Wed, 10 Mar 2021 17:51:14 GMT

←Older revision		Revision as of 17:51, 10 March 2021
Line 1:		Line 1:

	==Reverse Transcriptase Diabody with S82bC/R83T Mutation==		==Reverse Transcriptase Diabody with S82bC/R83T Mutation==
-	<StructureSection load='6vuo' size='340' side='right'caption='[[6vuo]]' scene=''>	+	<StructureSection load='6vuo' size='340' side='right'caption='[[6vuo]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vuo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VUO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vuo OCA], [https://pdbe.org/6vuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vuo RCSB], [https://www.ebi.ac.uk/pdbsum/6vuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vuo ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">scFv ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vuo OCA], [https://pdbe.org/6vuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vuo RCSB], [https://www.ebi.ac.uk/pdbsum/6vuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vuo ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This work presents a method for introducing synthetic symmetry into protein crystallization samples using an antibody fragment termed a diabody (Dab). These Dabs contain two target binding sites, and engineered disulfide bonds have been included to modulate Dab flexibility. The impacts of Dab engineering have been observed through assessment of thermal stability, small-angle X-ray scattering, and high-resolution crystal structures. Complexes between the engineered Dabs and HIV-1 reverse transcriptase (RT) bound to a high-affinity DNA aptamer were also generated to explore the capacity of engineered Dabs to enable the crystallization of bound target proteins. This strategy increased the crystallization hit frequency obtained for RT-aptamer, and the structure of a Dab-RT-aptamer complex was determined to 3.0-A resolution. Introduction of synthetic symmetry using a Dab could be a broadly applicable strategy, especially when monoclonal antibodies for a target have previously been identified.
		+
		+	Co-crystallization with diabodies: a case study for the introduction of synthetic symmetry.,Chesterman C, Arnold E Structure. 2021 Feb 23. pii: S0969-2126(21)00045-9. doi:, 10.1016/j.str.2021.02.001. PMID:33636101<ref>PMID:33636101</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vuo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arnold E]]	+	[[Category: Arnold, E]]
-	[[Category: Chelsy C]]	+	[[Category: Chelsy, C]]
		+	[[Category: Antibody fragment]]
		+	[[Category: Protein binding]]

OCA at 09:56, 17 February 2021

OCA — Wed, 17 Feb 2021 09:56:15 GMT

←Older revision		Revision as of 09:56, 17 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6vuo ~~is ON HOLD until Paper Publication~~	+	==Reverse Transcriptase Diabody with S82bC/R83T Mutation==
-		+	<StructureSection load='6vuo' size='340' side='right'caption='[[6vuo]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VUO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vuo OCA], [https://pdbe.org/6vuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vuo RCSB], [https://www.ebi.ac.uk/pdbsum/6vuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vuo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arnold E]]
		+	[[Category: Chelsy C]]

OCA at 05:09, 25 November 2020

OCA — Wed, 25 Nov 2020 05:09:19 GMT

←Older revision		Revision as of 05:09, 25 November 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vuo is ON HOLD	+	The entry 6vuo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vuo" [edit=sysop:move=sysop]

OCA — Wed, 26 Feb 2020 08:10:34 GMT

Protected "6vuo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:10, 26 February 2020

OCA: New page: '''Unreleased structure''' The entry 6vuo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Feb 2020 08:10:33 GMT

New page: '''Unreleased structure''' The entry 6vuo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vuo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]