6vyd - Revision history

OCA at 08:22, 11 October 2023

OCA — Wed, 11 Oct 2023 08:22:39 GMT

←Older revision		Revision as of 08:22, 11 October 2023
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	<StructureSection load='6vyd' size='340' side='right'caption='[[6vyd]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='6vyd' size='340' side='right'caption='[[6vyd]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6vyd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fusarium_graminearum~~ Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6VYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum_PH-1 Fusarium graminearum PH-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VYD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTM:N-BENZYL-N,N-DIETHYLETHANAMINIUM'>BTM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGRAMPH1_01T04331 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=229533 Fusarium graminearum])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTM:N-BENZYL-N,N-DIETHYLETHANAMINIUM'>BTM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6vyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyd OCA], [~~http~~://pdbe.org/6vyd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6vyd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6vyd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyd OCA], [https://pdbe.org/6vyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vyd RCSB], [https://www.ebi.ac.uk/pdbsum/6vyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/I1RDR8_GIBZE I1RDR8_GIBZE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fusarium graminearum]]	+	[[Category: Fusarium graminearum PH-1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Christianson~~, D W~~]]	+	[[Category: Christianson DW]]
-	[[Category: Herbst-Gervasoni~~, C J]]~~	+	[[Category: Herbst-Gervasoni CJ]]
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Terpene]]~~	+
-	~~[[Category: Terpenoid]]~~	+
-	~~[[Category: Terpenoid cyclase~~]]	+

OCA at 08:22, 20 January 2021

OCA — Wed, 20 Jan 2021 08:22:13 GMT

←Older revision		Revision as of 08:22, 20 January 2021
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	==Terpenoid Cyclase FgGS in Complex with Mg, Inorganic Pyrophosphate, and Benzyltriethylammonium cation==		==Terpenoid Cyclase FgGS in Complex with Mg, Inorganic Pyrophosphate, and Benzyltriethylammonium cation==
-	<StructureSection load='6vyd' size='340' side='right'caption='[[6vyd]]' scene=''>	+	<StructureSection load='6vyd' size='340' side='right'caption='[[6vyd]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6vyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VYD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyd OCA], [http://pdbe.org/6vyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vyd RCSB], [http://www.ebi.ac.uk/pdbsum/6vyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyd ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTM:N-BENZYL-N,N-DIETHYLETHANAMINIUM'>BTM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGRAMPH1_01T04331 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=229533 Fusarium graminearum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyd OCA], [http://pdbe.org/6vyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vyd RCSB], [http://www.ebi.ac.uk/pdbsum/6vyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyd ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Catalytic versatility is an inherent property of many enzymes. In nature, terpene cyclases comprise the foundation of molecular biodiversity as they generate diverse hydrocarbon scaffolds found in thousands of terpenoid natural products. Here, we report that the catalytic activity of the terpene cyclases AaTPS and FgGS can be switched from cyclase to aromatic prenyltransferase at basic pH to generate prenylindoles. The crystal structures of AaTPS and FgGS provide insights into the catalytic mechanism of this cryptic function. Moreover, aromatic prenyltransferase activity discovered in other terpene cyclases indicates that this cryptic function is broadly conserved among the greater family of terpene cyclases. We suggest that this cryptic function is chemoprotective for the cell by regulating isoprenoid diphosphate concentrations so that they are maintained below toxic thresholds.
		+
		+	Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases.,He H, Bian G, Herbst-Gervasoni CJ, Mori T, Shinsky SA, Hou A, Mu X, Huang M, Cheng S, Deng Z, Christianson DW, Abe I, Liu T Nat Commun. 2020 Aug 7;11(1):3958. doi: 10.1038/s41467-020-17642-2. PMID:32769971<ref>PMID:32769971</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6vyd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fusarium graminearum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Christianson DW]]	+	[[Category: Christianson, D W]]
-	[[Category: Herbst-Gervasoni CJ]]	+	[[Category: Herbst-Gervasoni, C J]]
		+	[[Category: Lyase]]
		+	[[Category: Terpene]]
		+	[[Category: Terpenoid]]
		+	[[Category: Terpenoid cyclase]]

OCA at 14:07, 8 July 2020

OCA — Wed, 08 Jul 2020 14:07:42 GMT

←Older revision		Revision as of 14:07, 8 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6vyd ~~is ON HOLD until Paper Publication~~	+	==Terpenoid Cyclase FgGS in Complex with Mg, Inorganic Pyrophosphate, and Benzyltriethylammonium cation==
-		+	<StructureSection load='6vyd' size='340' side='right'caption='[[6vyd]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VYD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyd OCA], [http://pdbe.org/6vyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vyd RCSB], [http://www.ebi.ac.uk/pdbsum/6vyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyd ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Christianson DW]]
		+	[[Category: Herbst-Gervasoni CJ]]

OCA at 04:22, 6 May 2020

OCA — Wed, 06 May 2020 04:22:58 GMT

←Older revision		Revision as of 04:22, 6 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6vyd is ON HOLD	+	The entry 6vyd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6vyd" [edit=sysop:move=sysop]

OCA — Wed, 04 Mar 2020 05:40:01 GMT

Protected "6vyd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 4 March 2020

OCA: New page: '''Unreleased structure''' The entry 6vyd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Mar 2020 05:39:59 GMT

New page: '''Unreleased structure''' The entry 6vyd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6vyd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]