6w69 - Revision history

OCA at 14:17, 18 October 2023

OCA — Wed, 18 Oct 2023 14:17:36 GMT

←Older revision		Revision as of 14:17, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='6w69' size='340' side='right'caption='[[6w69]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6w69' size='340' side='right'caption='[[6w69]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6w69]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W69 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6W69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6w69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W69 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~KEAP1~~, ~~INRF2, KIAA0132, KLHL19 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.501Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6w69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w69 OCA], [~~http~~://pdbe.org/6w69 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6w69 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6w69 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6w69 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w69 OCA], [https://pdbe.org/6w69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w69 RCSB], [https://www.ebi.ac.uk/pdbsum/6w69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w69 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gee~~, C L~~]]	+	[[Category: Gee CL]]
-	[[Category: Kuriyan, J]]	+	[[Category: Kuriyan J]]
-	[[Category: Mena~~, E L~~]]	+	[[Category: Mena EL]]
-	[[Category: Rape, M]]	+	[[Category: Rape M]]
-	~~[[Category: Btb domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:08, 2 September 2020

OCA — Wed, 02 Sep 2020 07:08:17 GMT

←Older revision		Revision as of 07:08, 2 September 2020
Line 1:		Line 1:

	==The structure of F64, S172A Keap1-BTB domain==		==The structure of F64, S172A Keap1-BTB domain==
-	<StructureSection load='6w69' size='340' side='right'caption='[[6w69]]' scene=''>	+	<StructureSection load='6w69' size='340' side='right'caption='[[6w69]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W69 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6w69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W69 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W69 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w69 OCA], [http://pdbe.org/6w69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w69 RCSB], [http://www.ebi.ac.uk/pdbsum/6w69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w69 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w69 OCA], [http://pdbe.org/6w69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w69 RCSB], [http://www.ebi.ac.uk/pdbsum/6w69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w69 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Most quality control pathways target misfolded proteins to prevent toxic aggregation and neurodegeneration(1). Dimerization quality control further improves proteostasis by eliminating complexes of aberrant composition(2), but how it detects incorrect subunits remains unknown. Here we provide structural insight into target selection by SCF-FBXL17, a dimerization-quality-control E3 ligase that ubiquitylates and helps to degrade inactive heterodimers of BTB proteins while sparing functional homodimers. We find that SCF-FBXL17 disrupts aberrant BTB dimers that fail to stabilize an intermolecular beta-sheet around a highly divergent beta-strand of the BTB domain. Complex dissociation allows SCF-FBXL17 to wrap around a single BTB domain, resulting in robust ubiquitylation. SCF-FBXL17 therefore probes both shape and complementarity of BTB domains, a mechanism that is well suited to establish quality control of complex composition for recurrent interaction modules.
		+
		+	Structural basis for dimerization quality control.,Mena EL, Jevtic P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M Nature. 2020 Aug 19. pii: 10.1038/s41586-020-2636-7. doi:, 10.1038/s41586-020-2636-7. PMID:32814905<ref>PMID:32814905</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6w69" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gee CL]]	+	[[Category: Gee, C L]]
-	[[Category: Kuriyan J]]	+	[[Category: Kuriyan, J]]
-	[[Category: Mena EL]]	+	[[Category: Mena, E L]]
-	[[Category: Rape M]]	+	[[Category: Rape, M]]
		+	[[Category: Btb domain]]
		+	[[Category: Signaling protein]]

OCA at 06:21, 19 August 2020

OCA — Wed, 19 Aug 2020 06:21:29 GMT

←Older revision		Revision as of 06:21, 19 August 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6w69 ~~is ON HOLD until Paper Publication~~	+	==The structure of F64, S172A Keap1-BTB domain==
-		+	<StructureSection load='6w69' size='340' side='right'caption='[[6w69]]' scene=''>
-	~~Authors~~: ~~Mena~~, E.L., ~~Gee~~, C.L., ~~Kuriyan, J~~., ~~Rape, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W69 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W69 FirstGlance]. <br>
-	~~Description: The structure of F64, S172A Keap1-BTB domain~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w69 OCA], [http://pdbe.org/6w69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w69 RCSB], [http://www.ebi.ac.uk/pdbsum/6w69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w69 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Gee~~, C.L~~]]	+	__TOC__
-	[[Category: Kuriyan, J]]	+	</StructureSection>
-	[[Category: Mena~~, E.L~~]]	+	[[Category: Large Structures]]
-	[[Category: Rape, M]]	+	[[Category: Gee CL]]
		+	[[Category: Kuriyan J]]
		+	[[Category: Mena EL]]
		+	[[Category: Rape M]]

OCA at 05:09, 29 April 2020

OCA — Wed, 29 Apr 2020 05:09:24 GMT

←Older revision		Revision as of 05:09, 29 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6w69 is ON HOLD	+	The entry 6w69 is ON HOLD until Paper Publication

	Authors: Mena, E.L., Gee, C.L., Kuriyan, J., Rape, M.		Authors: Mena, E.L., Gee, C.L., Kuriyan, J., Rape, M.

OCA: Protected "6w69" [edit=sysop:move=sysop]

OCA — Fri, 27 Mar 2020 08:25:07 GMT

Protected "6w69" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:25, 27 March 2020

OCA: New page: '''Unreleased structure''' The entry 6w69 is ON HOLD Authors: Mena, E.L., Gee, C.L., Kuriyan, J., Rape, M. Description: The structure of F64, S172A Keap1-BTB domain [[Category: Unrelea...

OCA — Fri, 27 Mar 2020 08:25:06 GMT

New page: '''Unreleased structure''' The entry 6w69 is ON HOLD Authors: Mena, E.L., Gee, C.L., Kuriyan, J., Rape, M. Description: The structure of F64, S172A Keap1-BTB domain [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 6w69 is ON HOLD

Authors: Mena, E.L., Gee, C.L., Kuriyan, J., Rape, M.

Description: The structure of F64, S172A Keap1-BTB domain
[[Category: Unreleased Structures]]
[[Category: Gee, C.L]]
[[Category: Kuriyan, J]]
[[Category: Mena, E.L]]
[[Category: Rape, M]]