6w8v - Revision history

OCA at 14:18, 18 October 2023

OCA — Wed, 18 Oct 2023 14:18:55 GMT

←Older revision		Revision as of 14:18, 18 October 2023
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	==Crystal structure of mouse DNMT1 in complex with ACG DNA==		==Crystal structure of mouse DNMT1 in complex with ACG DNA==
-	<StructureSection load='6w8v' size='340' side='right'caption='[[6w8v]]' scene=''>	+	<StructureSection load='6w8v' size='340' side='right'caption='[[6w8v]], [[Resolution\|resolution]] 3.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W8V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6W8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6w8v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W8V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6w8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w8v OCA], [~~http~~://pdbe.org/6w8v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6w8v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6w8v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6w8v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.12Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=C49:4-THIO,5-FLUORO,5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C49</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w8v OCA], [https://pdbe.org/6w8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w8v RCSB], [https://www.ebi.ac.uk/pdbsum/6w8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w8v ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DNMT1_MOUSE DNMT1_MOUSE] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.<ref>PMID:11290321</ref> <ref>PMID:15550930</ref> <ref>PMID:17576694</ref>
		+
		+	==See Also==
		+	*[[DNA methyltransferase 3D structures\|DNA methyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Synthetic construct]]
	[[Category: Anteneh H]]		[[Category: Anteneh H]]
	[[Category: Song J]]		[[Category: Song J]]

OCA at 14:08, 8 July 2020

OCA — Wed, 08 Jul 2020 14:08:13 GMT

←Older revision		Revision as of 14:08, 8 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6w8v ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of mouse DNMT1 in complex with ACG DNA==
-		+	<StructureSection load='6w8v' size='340' side='right'caption='[[6w8v]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W8V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W8V FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w8v OCA], [http://pdbe.org/6w8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w8v RCSB], [http://www.ebi.ac.uk/pdbsum/6w8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w8v ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Anteneh H]]
		+	[[Category: Song J]]

OCA at 03:58, 13 May 2020

OCA — Wed, 13 May 2020 03:58:28 GMT

←Older revision		Revision as of 03:58, 13 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6w8v is ON HOLD	+	The entry 6w8v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6w8v" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2020 07:28:40 GMT

Protected "6w8v" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:28, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 6w8v is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Apr 2020 07:28:38 GMT

New page: '''Unreleased structure''' The entry 6w8v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6w8v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]