6wap - Revision history

OCA at 11:06, 14 June 2023

OCA — Wed, 14 Jun 2023 11:06:34 GMT

←Older revision		Revision as of 11:06, 14 June 2023
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	==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==		==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==
-	<StructureSection load='6wap' size='340' side='right'caption='[[6wap~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6wap' size='340' side='right'caption='[[6wap]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6wap]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [https://pdbe.org/6wap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [https://www.ebi.ac.uk/pdbsum/6wap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [~~http~~://pdbe.org/6wap PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wap PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).	+	[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 6wap" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6wap" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bryer, A]]	+	[[Category: Bryer A]]
-	[[Category: Gronenborn~~, A M~~]]	+	[[Category: Gronenborn AM]]
-	[[Category: Hou, G]]	+	[[Category: Hou G]]
-	[[Category: Lu, M]]	+	[[Category: Lu M]]
-	[[Category: Perilla~~, J R~~]]	+	[[Category: Perilla JR]]
-	[[Category: Polenova, T]]	+	[[Category: Polenova T]]
-	[[Category: Quinn~~, C M~~]]	+	[[Category: Quinn CM]]
-	[[Category: Russell~~, R W~~]]	+	[[Category: Russell RW]]
-	[[Category: Schwieters~~, C D~~]]	+	[[Category: Schwieters CD]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Ca protein assembly]]~~	+
-	~~[[Category: Hiv-1 capsid]]~~	+
-	~~[[Category: Hiv-aid]]~~	+
-	~~[[Category: Magic angle spinning nmr]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 11:29, 23 September 2020

OCA — Wed, 23 Sep 2020 11:29:19 GMT

←Older revision		Revision as of 11:29, 23 September 2020
Line 1:		Line 1:

	==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==		==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==
-	<StructureSection load='6wap' size='340' side='right'caption='[[6wap]]' scene=''>	+	<StructureSection load='6wap' size='340' side='right'caption='[[6wap]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [http://pdbe.org/6wap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [http://www.ebi.ac.uk/pdbsum/6wap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [http://pdbe.org/6wap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [http://www.ebi.ac.uk/pdbsum/6wap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HIV-1 capsid plays multiple key roles in viral replication, and inhibition of capsid assembly is an attractive target for therapeutic intervention. Here, we report the atomic-resolution structure of capsid protein (CA) tubes, determined by magic-angle spinning NMR and data-guided molecular dynamics simulations. Functionally important regions, including the NTD beta-hairpin, the cyclophilin A-binding loop, residues in the hexamer central pore, and the NTD-CTD linker region, are well defined. The structure of individual CA chains, their arrangement in the pseudo-hexameric units of the tube and the inter-hexamer interfaces are consistent with those in intact capsids and substantially different from the organization in crystal structures, which feature flat hexamers. The inherent curvature in the CA tubes is controlled by conformational variability of residues in the linker region and of dimer and trimer interfaces. The present structure reveals atomic-level detail in capsid architecture and provides important guidance for the design of novel capsid inhibitors.
		+
		+	Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR.,Lu M, Russell RW, Bryer AJ, Quinn CM, Hou G, Zhang H, Schwieters CD, Perilla JR, Gronenborn AM, Polenova T Nat Struct Mol Biol. 2020 Sep;27(9):863-869. doi: 10.1038/s41594-020-0489-2. Epub, 2020 Sep 8. PMID:32901160<ref>PMID:32901160</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wap" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bryer A]]	+	[[Category: Bryer, A]]
-	[[Category: Gronenborn AM]]	+	[[Category: Gronenborn, A M]]
-	[[Category: Hou G]]	+	[[Category: Hou, G]]
-	[[Category: Lu M]]	+	[[Category: Lu, M]]
-	[[Category: Perilla JR]]	+	[[Category: Perilla, J R]]
-	[[Category: Polenova T]]	+	[[Category: Polenova, T]]
-	[[Category: Quinn CM]]	+	[[Category: Quinn, C M]]
-	[[Category: Russell RW]]	+	[[Category: Russell, R W]]
-	[[Category: Schwieters CD]]	+	[[Category: Schwieters, C D]]
-	[[Category: Zhang H]]	+	[[Category: Zhang, H]]
		+	[[Category: Ca protein assembly]]
		+	[[Category: Hiv-1 capsid]]
		+	[[Category: Hiv-aid]]
		+	[[Category: Magic angle spinning nmr]]
		+	[[Category: Viral protein]]

OCA at 06:49, 2 September 2020

OCA — Wed, 02 Sep 2020 06:49:59 GMT

←Older revision		Revision as of 06:49, 2 September 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6wap is ~~ON HOLD until Paper Publication~~	+	==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==
-		+	<StructureSection load='6wap' size='340' side='right'caption='[[6wap]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [http://pdbe.org/6wap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [http://www.ebi.ac.uk/pdbsum/6wap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bryer A]]
		+	[[Category: Gronenborn AM]]
		+	[[Category: Hou G]]
		+	[[Category: Lu M]]
		+	[[Category: Perilla JR]]
		+	[[Category: Polenova T]]
		+	[[Category: Quinn CM]]
		+	[[Category: Russell RW]]
		+	[[Category: Schwieters CD]]
		+	[[Category: Zhang H]]

OCA at 04:29, 19 August 2020

OCA — Wed, 19 Aug 2020 04:29:49 GMT

←Older revision		Revision as of 04:29, 19 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wap is ON HOLD	+	The entry 6wap is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6wap" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2020 07:34:38 GMT

Protected "6wap" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:34, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wap is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Apr 2020 07:34:36 GMT

New page: '''Unreleased structure''' The entry 6wap is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wap is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]