6wdp - Revision history

OCA at 06:25, 1 December 2021

OCA — Wed, 01 Dec 2021 06:25:06 GMT

←Older revision		Revision as of 06:25, 1 December 2021
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	<StructureSection load='6wdp' size='340' side='right'caption='[[6wdp]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='6wdp' size='340' side='right'caption='[[6wdp]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6wdp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WDP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WDP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL12RB1, IL12R, IL12RB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wdp OCA], [https://pdbe.org/6wdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wdp RCSB], [https://www.ebi.ac.uk/pdbsum/6wdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wdp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wdp OCA], [https://pdbe.org/6wdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wdp RCSB], [https://www.ebi.ac.uk/pdbsum/6wdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wdp ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]

OCA at 14:57, 3 March 2021

OCA — Wed, 03 Mar 2021 14:57:08 GMT

←Older revision		Revision as of 14:57, 3 March 2021
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	==Interleukin 12 receptor subunit beta-1==		==Interleukin 12 receptor subunit beta-1==
-	<StructureSection load='6wdp' size='340' side='right'caption='[[6wdp]]' scene=''>	+	<StructureSection load='6wdp' size='340' side='right'caption='[[6wdp]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WDP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wdp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WDP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wdp OCA], [https://pdbe.org/6wdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wdp RCSB], [https://www.ebi.ac.uk/pdbsum/6wdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wdp ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wdp OCA], [https://pdbe.org/6wdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wdp RCSB], [https://www.ebi.ac.uk/pdbsum/6wdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wdp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/I12R1_HUMAN I12R1_HUMAN]] Primary biliary cholangitis;Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/I12R1_HUMAN I12R1_HUMAN]] Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.<ref>PMID:12023369</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that are produced by antigen-presenting cells to regulate the activation and differentiation of lymphocytes, and they share IL-12Rbeta1 as a receptor signaling subunit. We present a crystal structure of the quaternary IL-23 (IL-23p19/p40)/IL-23R/IL-12Rbeta1 complex, together with cryoelectron microscopy (cryo-EM) maps of the complete IL-12 (IL-12p35/p40)/IL-12Rbeta2/IL-12Rbeta1 and IL-23 receptor (IL-23R) complexes, which reveal "non-canonical" topologies where IL-12Rbeta1 directly engages the common p40 subunit. We targeted the shared IL-12Rbeta1/p40 interface to design a panel of IL-12 partial agonists that preserved interferon gamma (IFNgamma) induction by CD8(+) T cells but impaired cytokine production from natural killer (NK) cells in vitro. These cell-biased properties were recapitulated in vivo, where IL-12 partial agonists elicited anti-tumor immunity to MC-38 murine adenocarcinoma absent the NK-cell-mediated toxicity seen with wild-type IL-12. Thus, the structural mechanism of receptor sharing used by IL-12 family cytokines provides a protein interface blueprint for tuning this cytokine axis for therapeutics.
		+
		+	Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.,Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC Cell. 2021 Feb 18;184(4):983-999.e24. doi: 10.1016/j.cell.2021.01.018. PMID:33606986<ref>PMID:33606986</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wdp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Garcia KC]]	+	[[Category: Garcia, K C]]
-	[[Category: Jude KM]]	+	[[Category: Jude, K M]]
-	[[Category: Spangler JB]]	+	[[Category: Spangler, J B]]
-	[[Category: Thomas C]]	+	[[Category: Thomas, C]]
		+	[[Category: Cytokine receptor]]
		+	[[Category: Signaling protein]]

OCA at 06:38, 24 February 2021

OCA — Wed, 24 Feb 2021 06:38:44 GMT

←Older revision		Revision as of 06:38, 24 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6wdp is ~~ON HOLD until Paper Publication~~	+	==Interleukin 12 receptor subunit beta-1==
-		+	<StructureSection load='6wdp' size='340' side='right'caption='[[6wdp]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WDP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wdp OCA], [https://pdbe.org/6wdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wdp RCSB], [https://www.ebi.ac.uk/pdbsum/6wdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wdp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Garcia KC]]
		+	[[Category: Jude KM]]
		+	[[Category: Spangler JB]]
		+	[[Category: Thomas C]]

OCA at 04:11, 20 May 2020

OCA — Wed, 20 May 2020 04:11:33 GMT

←Older revision		Revision as of 04:11, 20 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wdp is ON HOLD	+	The entry 6wdp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6wdp" [edit=sysop:move=sysop]

OCA — Wed, 08 Apr 2020 05:38:45 GMT

Protected "6wdp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 8 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wdp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Apr 2020 05:38:44 GMT

New page: '''Unreleased structure''' The entry 6wdp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wdp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]