6wez - Revision history

OCA at 07:09, 3 April 2024

OCA — Wed, 03 Apr 2024 07:09:57 GMT

←Older revision		Revision as of 07:09, 3 April 2024
Line 1:		Line 1:

-	====	+	==Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H3 Hemagglutinin==
-	<StructureSection load='6wez' size='340' side='right'caption='[[6wez]]' scene=''>	+	<StructureSection load='6wez' size='340' side='right'caption='[[6wez]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wez]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WEZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wez OCA], [https://pdbe.org/6wez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wez RCSB], [https://www.ebi.ac.uk/pdbsum/6wez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wez ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.21Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wez OCA], [https://pdbe.org/6wez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wez RCSB], [https://www.ebi.ac.uk/pdbsum/6wez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wez ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A5P1MU07_9INFA A0A5P1MU07_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Attatippaholkun N]]
		+	[[Category: Deming DT]]
		+	[[Category: Harshbarger WD]]
		+	[[Category: Lockbaum GJ]]
		+	[[Category: Marasco WA]]
		+	[[Category: Schiffer CA]]

OCA at 12:25, 9 June 2021

OCA — Wed, 09 Jun 2021 12:25:08 GMT

←Older revision		Revision as of 12:25, 9 June 2021
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	<StructureSection load='6wez' size='340' side='right'caption='[[6wez]]' scene=''>		<StructureSection load='6wez' size='340' side='right'caption='[[6wez]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wez OCA], [~~http~~://pdbe.org/6wez PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wez RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wez PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wez ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wez OCA], [https://pdbe.org/6wez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wez RCSB], [https://www.ebi.ac.uk/pdbsum/6wez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wez ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 06:54, 25 November 2020

OCA — Wed, 25 Nov 2020 06:54:37 GMT

←Older revision		Revision as of 06:54, 25 November 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6wez ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6wez' size='340' side='right'caption='[[6wez]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wez OCA], [http://pdbe.org/6wez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wez RCSB], [http://www.ebi.ac.uk/pdbsum/6wez PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wez ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:01, 13 May 2020

OCA — Wed, 13 May 2020 04:01:31 GMT

←Older revision		Revision as of 04:01, 13 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wez is ON HOLD	+	The entry 6wez is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6wez" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:21:50 GMT

Protected "6wez" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wez is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Apr 2020 05:21:48 GMT

New page: '''Unreleased structure''' The entry 6wez is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wez is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]