6wgf - Revision history

OCA at 14:44, 6 March 2024

OCA — Wed, 06 Mar 2024 14:44:03 GMT

←Older revision		Revision as of 14:44, 6 March 2024
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-	====	+	==Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation==
-	<StructureSection load='6wgf' size='340' side='right'caption='[[6wgf]]' scene=''>	+	<StructureSection load='6wgf' size='340' side='right'caption='[[6wgf]], [[Resolution\|resolution]] 7.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wgf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WGF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wgf OCA], [~~http~~://pdbe.org/6wgf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wgf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wgf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wgf ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 7.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wgf OCA], [https://pdbe.org/6wgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wgf RCSB], [https://www.ebi.ac.uk/pdbsum/6wgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wgf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MCM2_YEAST MCM2_YEAST] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth.<ref>PMID:19896182</ref> <ref>PMID:19910535</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Bai L]]
		+	[[Category: Dodd T]]
		+	[[Category: Ivanov I]]
		+	[[Category: Li H]]
		+	[[Category: Magdalou I]]
		+	[[Category: Riera A]]
		+	[[Category: Schneider S]]
		+	[[Category: Speck C]]
		+	[[Category: Stillman B]]
		+	[[Category: Yan C]]
		+	[[Category: Yuan Z]]

OCA at 11:44, 22 July 2020

OCA — Wed, 22 Jul 2020 11:44:05 GMT

←Older revision		Revision as of 11:44, 22 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6wgf ~~is ON HOLD~~	+	====
-		+	<StructureSection load='6wgf' size='340' side='right'caption='[[6wgf]]' scene=''>
-	~~Authors~~: ~~Yuan, Z~~.~~, Schneider, S~~.~~, Dodd, T~~.~~, Riera, A~~.~~, Bai, L~~.~~, Yan, C~~.~~, Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wgf OCA], [http://pdbe.org/6wgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wgf RCSB], [http://www.ebi.ac.uk/pdbsum/6wgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wgf ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Bai, L~~]]	+	__TOC__
-	~~[[Category: Riera~~, ~~A]]~~	+	</StructureSection>
-	[~~[Category~~: ~~Li, H~~]]	+	[[Category: Large Structures]]
-	~~[[Category: Ivanov~~, ~~I]]~~	+	[[Category: Z-disk]]
-	[~~[Category~~: ~~Yuan, Z~~]]	+
-	~~[[Category: Dodd~~, ~~T]]~~	+
-	[~~[Category~~: ~~Yan, C~~]]	+
-	~~[[Category: Stillman~~, ~~B]]~~	+
-	[~~[Category~~: ~~Speck, C]~~]	+
-	[[Category: ~~Schneider, S~~]]	+
-	[[Category: ~~Magdalou, I~~]]	+

OCA: Protected "6wgf" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:25:53 GMT

Protected "6wgf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wgf is ON HOLD Authors: Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C. ...

OCA — Wed, 15 Apr 2020 05:25:52 GMT

New page: '''Unreleased structure''' The entry 6wgf is ON HOLD Authors: Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C. ...

New page

'''Unreleased structure'''

The entry 6wgf is ON HOLD

Authors: Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.

Description: Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
[[Category: Unreleased Structures]]
[[Category: Bai, L]]
[[Category: Riera, A]]
[[Category: Li, H]]
[[Category: Ivanov, I]]
[[Category: Yuan, Z]]
[[Category: Dodd, T]]
[[Category: Yan, C]]
[[Category: Stillman, B]]
[[Category: Speck, C]]
[[Category: Schneider, S]]
[[Category: Magdalou, I]]