6wh4 - Revision history

OCA at 14:24, 18 October 2023

OCA — Wed, 18 Oct 2023 14:24:55 GMT

←Older revision		Revision as of 14:24, 18 October 2023
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	==Crystal structure of HTR2A with inverse agonist==		==Crystal structure of HTR2A with inverse agonist==
-	<StructureSection load='6wh4' size='340' side='right'caption='[[6wh4]]' scene=''>	+	<StructureSection load='6wh4' size='340' side='right'caption='[[6wh4]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WH4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6WH4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wh4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WH4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wh4 OCA], [~~http~~://pdbe.org/6wh4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wh4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wh4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wh4 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=89F:1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine'>89F</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NDS:ETHYL+DIMETHYL+AMMONIO+PROPANE+SULFONATE'>NDS</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wh4 OCA], [https://pdbe.org/6wh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wh4 RCSB], [https://www.ebi.ac.uk/pdbsum/6wh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wh4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT2A_HUMAN 5HT2A_HUMAN] G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.<ref>PMID:1330647</ref> <ref>PMID:18297054</ref> <ref>PMID:18703043</ref> <ref>PMID:19057895</ref> <ref>PMID:21645528</ref> <ref>PMID:22300836</ref> <ref>PMID:28129538</ref> (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.<ref>PMID:24089568</ref>
		+
		+	==See Also==
		+	*[[5-hydroxytryptamine receptor 3D structures\|5-hydroxytryptamine receptor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Che T]]		[[Category: Che T]]

OCA at 11:11, 23 September 2020

OCA — Wed, 23 Sep 2020 11:11:43 GMT

←Older revision		Revision as of 11:11, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6wh4 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of HTR2A with inverse agonist==
-		+	<StructureSection load='6wh4' size='340' side='right'caption='[[6wh4]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WH4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WH4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wh4 OCA], [http://pdbe.org/6wh4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wh4 RCSB], [http://www.ebi.ac.uk/pdbsum/6wh4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wh4 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Che T]]
		+	[[Category: Kim KL]]
		+	[[Category: Krumm BE]]
		+	[[Category: Roth BL]]

OCA at 09:04, 26 August 2020

OCA — Wed, 26 Aug 2020 09:04:36 GMT

←Older revision		Revision as of 09:04, 26 August 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wh4 is ON HOLD	+	The entry 6wh4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 09:20, 29 July 2020

OCA — Wed, 29 Jul 2020 09:20:03 GMT

←Older revision		Revision as of 09:20, 29 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wh4 is ON HOLD ~~until sometime in the future~~	+	The entry 6wh4 is ON HOLD

	Authors:		Authors:

OCA at 06:29, 22 July 2020

OCA — Wed, 22 Jul 2020 06:29:36 GMT

←Older revision		Revision as of 06:29, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wh4 is ON HOLD	+	The entry 6wh4 is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "6wh4" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:27:26 GMT

Protected "6wh4" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wh4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Apr 2020 05:27:24 GMT

New page: '''Unreleased structure''' The entry 6wh4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wh4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]